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{{CL
{{CL
|id=CL:0000815
|alt_id=
|name=regulatory T cell
|namespace=cell;;efo
|def="A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GO_REF:0000031, GOC:add]
|xref=BTO:0004520;;FMA:84070
|is_a=CL:0002419
|synonym="regulatory T lymphocyte" EXACT [];;"regulatory T-cell" EXACT [];;"regulatory T-lymphocyte" EXACT [];;"suppressor T cell" BROAD [];;"suppressor T lymphocyte" BROAD [];;"suppressor T-cell" BROAD [];;"suppressor T-lymphocyte" BROAD []
|comment=This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta.
|comment=This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta.
|alt_id=
|disjoint_from=
|union_of=
|created_by=
|created_by=
|obo_creation_date=
|def="A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GO_REF:0000031, GOC:add]
|subset=
|derives_from=
|derives_from=
|develops_from=
|develops_from=
|disjoint_from=
|has_quality=
|has_quality=
|id=CL:0000815
|is_a=CL:0002419
|is_obsolete=
|located_in=
|located_in=
|name=regulatory T cell
|namespace=cell;;efo
|obo_creation_date=
|part_of=
|part_of=
|preceded_by=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|is_obsolete=
|subset=
|preceded_by=
|synonym="regulatory T lymphocyte" EXACT [];;"regulatory T-cell" EXACT [];;"regulatory T-lymphocyte" EXACT [];;"suppressor T cell" BROAD [];;"suppressor T lymphocyte" BROAD [];;"suppressor T-cell" BROAD [];;"suppressor T-lymphocyte" BROAD []
|union_of=
|xref=BTO:0004520;;FMA:84070
}}
}}

Revision as of 10:21, 12 September 2014

Name:regulatory T cell
Namespace:cell;;efo
Definition:"A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GO_REF:0000031, GOC:add]
Xrefs:
links:

BTO:0004520

FMA:84070
Synonyms: "regulatory T lymphocyte" EXACT []
"regulatory T-cell" EXACT []
"regulatory T-lymphocyte" EXACT []
"suppressor T cell" BROAD []
"suppressor T lymphocyte" BROAD []
"suppressor T-cell" BROAD []
"suppressor T-lymphocyte" BROAD []
Comments:This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta.


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0002419(mature T cell)



Children


is a:CL:0000792 (CD4-positive, CD25-positive, alpha-beta regulatory T cell),FF:11943-126A8 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (BalbcA)),FF:11944-126A9 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (C57BL 6J)),FF:11946-126B2 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (BalbcA))

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.

Human (Homo sapiens)

  • 11780-124A7 (CD4+CD25+CD45RA+ naive regulatory T cells, donor1)
  • 11782-124A9 (CD4+CD25+CD45RA- memory regulatory T cells, donor1)
  • 11814-124E5 (CD4+CD25+ regulatory T cells, pool1 (C57BL_6J))
  • 11818-124E9 (CD4+CD25+ regulatory T cells, pool2 (Balb_cAJcl))
  • 11943-126A8 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (BalbcA))
  • 11944-126A9 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (C57BL 6J))
  • 11945-126B1 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (C57BL 6J))
  • 11946-126B2 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (BalbcA))

Mouse (Mus musculus)

  • 11780-124A7 (CD4+CD25+CD45RA+ naive regulatory T cells, donor1)
  • 11782-124A9 (CD4+CD25+CD45RA- memory regulatory T cells, donor1)
  • 11814-124E5 (CD4+CD25+ regulatory T cells, pool1 (C57BL_6J))
  • 11818-124E9 (CD4+CD25+ regulatory T cells, pool2 (Balb_cAJcl))
  • 11943-126A8 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (BalbcA))
  • 11944-126A9 (CD4+CD25+ regulatory T cells, antiCD3 CD28 stimulation, 06hr, pool1 (C57BL 6J))
  • 11945-126B1 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (C57BL 6J))
  • 11946-126B2 (CD4+CD25+ regulatory T cells, PMA and ionomycin stimulation, 02hr, pool1 (BalbcA))


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000815 (regulatory T cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
4.61e-131FFCP PHASE2:Hg19::chr1:113160702..113160706,-#_7ab95dd728078da90f616e2dae394ac4p21@ST7L
4.61e-131FFCP PHASE1:Hg19::chr1:113160702..113160706,-#_7ab95dd728078da90f616e2dae394ac4p21@ST7L
5.68e-99FFCP PHASE2:Hg19::chr11:111410267..111410269,+#_f728bf5dc8a8de558b9e23cc82f780cfp@chr11:111410267..111410269, +
5.68e-99FFCP PHASE1:Hg19::chr11:111410267..111410269,+#_f728bf5dc8a8de558b9e23cc82f780cfp@chr11:111410267..111410269, +
1.55e-98FFCP PHASE2:Hg19::chr3:73015629..73015632,+#_b0723bc5add031d9fbb142c1f032198bp@chr3:73015629..73015632, +
1.55e-98FFCP PHASE1:Hg19::chr3:73015629..73015632,+#_b0723bc5add031d9fbb142c1f032198bp@chr3:73015629..73015632, +
3.07e-86FFCP PHASE2:Mm9::chr9:14708334..14708341,-#_5884893199fa68790cd27702941e5924p11@Folr4
3.07e-86FFCP PHASE1:Mm9::chr17:12884847..12884852,-#_5884893199fa68790cd27702941e5924p@chr17:12884847..12884852, -
3.07e-86FFCP PHASE1:Mm9::chrX:7157611..7157617,+#_5884893199fa68790cd27702941e5924p4@Foxp3
3.07e-86FFCP PHASE1:Mm9::chr8:93597971..93597979,+#_5884893199fa68790cd27702941e5924p@chr8:93597971..93597979, +
3.07e-86FFCP PHASE2:Mm9::chr1:69595515..69595518,-#_5884893199fa68790cd27702941e5924p@chr1:69595515..69595518, -
3.07e-86FFCP PHASE1:Mm9::chr6:49536818..49536841,+#_5884893199fa68790cd27702941e5924p@chr6:49536818..49536841, +
3.07e-86FFCP PHASE1:Mm9::chr9:123843234..123843237,+#_5884893199fa68790cd27702941e5924p@chr9:123843234..123843237, +
3.07e-86FFCP PHASE2:Mm9::chr1:69815958..69815961,+#_5884893199fa68790cd27702941e5924p@chr1:69815958..69815961, +
3.07e-86FFCP PHASE2:Mm9::chr4:32512204..32512214,+#_5884893199fa68790cd27702941e5924p@chr4:32512204..32512214, +
3.07e-86FFCP PHASE1:Mm9::chr1:60970510..60970516,+#_5884893199fa68790cd27702941e5924p@chr1:60970510..60970516, +
3.07e-86FFCP PHASE2:Mm9::chr9:14706346..14706355,-#_5884893199fa68790cd27702941e5924p@chr9:14706346..14706355, -
3.07e-86FFCP PHASE2:Mm9::chr13:105413537..105413540,+#_5884893199fa68790cd27702941e5924p@chr13:105413537..105413540, +
3.07e-86FFCP PHASE2:Mm9::chr9:123843234..123843237,+#_5884893199fa68790cd27702941e5924p@chr9:123843234..123843237, +
3.07e-86FFCP PHASE1:Mm9::chr15:59357130..59357143,-#_5884893199fa68790cd27702941e5924p@chr15:59357130..59357143, -
3.07e-86FFCP PHASE1:Mm9::chr1:60944205..60944230,+#_5884893199fa68790cd27702941e5924p@chr1:60944205..60944230, +
3.07e-86FFCP PHASE1:Mm9::chr10:13779506..13779514,-#_5884893199fa68790cd27702941e5924p@chr10:13779506..13779514, -
3.07e-86FFCP PHASE2:Mm9::chr8:129378573..129378577,+#_5884893199fa68790cd27702941e5924p@chr8:129378573..129378577, +
3.07e-86FFCP PHASE1:Mm9::chrX:7170204..7170205,+#_5884893199fa68790cd27702941e5924p@chrX:7170204..7170205, +
3.07e-86FFCP PHASE1:Mm9::chr8:74526522..74526532,-#_5884893199fa68790cd27702941e5924p@chr8:74526522..74526532, -
3.07e-86FFCP PHASE2:Mm9::chr6:48670473..48670480,+#_5884893199fa68790cd27702941e5924p@chr6:48670473..48670480, +
3.07e-86FFCP PHASE2:Mm9::chr12:108370128..108370136,-#_5884893199fa68790cd27702941e5924p@chr12:108370128..108370136, -
3.07e-86FFCP PHASE1:Mm9::chr7:121283156..121283178,+#_5884893199fa68790cd27702941e5924p@chr7:121283156..121283178, +
3.07e-86FFCP PHASE1:Mm9::chr12:114668438..114668451,+#_5884893199fa68790cd27702941e5924p@chr12:114668438..114668451, +
3.07e-86FFCP PHASE1:Mm9::chr9:14662914..14662922,+#_5884893199fa68790cd27702941e5924p@chr9:14662914..14662922, +
3.07e-86FFCP PHASE2:Mm9::chr8:74526430..74526446,-#_5884893199fa68790cd27702941e5924p@chr8:74526430..74526446, -
3.07e-86FFCP PHASE1:Mm9::chr9:69148201..69148218,-#_5884893199fa68790cd27702941e5924p@chr9:69148201..69148218, -
3.07e-86FFCP PHASE2:Mm9::chr10:22022863..22022865,+#_5884893199fa68790cd27702941e5924p@chr10:22022863..22022865, +
3.07e-86FFCP PHASE1:Mm9::chr7:108729732..108729745,+#_5884893199fa68790cd27702941e5924p@chr7:108729732..108729745, +
3.07e-86FFCP PHASE2:Mm9::chr1:60944205..60944230,+#_5884893199fa68790cd27702941e5924p@chr1:60944205..60944230, +
3.07e-86FFCP PHASE1:Mm9::chr4:155400229..155400241,+#_5884893199fa68790cd27702941e5924p3@Tnfrsf18
3.07e-86FFCP PHASE2:Mm9::chr13:46831423..46831426,+#_5884893199fa68790cd27702941e5924p@chr13:46831423..46831426, +
3.07e-86FFCP PHASE1:Mm9::chr17:26709187..26709203,-#_5884893199fa68790cd27702941e5924p@chr17:26709187..26709203, -
3.07e-86FFCP PHASE1:Mm9::chr6:48670473..48670480,+#_5884893199fa68790cd27702941e5924p@chr6:48670473..48670480, +
3.07e-86FFCP PHASE2:Mm9::chrX:7161059..7161081,-#_5884893199fa68790cd27702941e5924p@chrX:7161059..7161081, -
3.07e-86FFCP PHASE2:Mm9::chr1:60970179..60970192,-#_5884893199fa68790cd27702941e5924p@chr1:60970179..60970192, -
3.07e-86FFCP PHASE2:Mm9::chr17:12884884..12884887,-#_5884893199fa68790cd27702941e5924p@chr17:12884884..12884887, -
3.07e-86FFCP PHASE1:Mm9::chr1:69729950..69729959,-#_5884893199fa68790cd27702941e5924p@chr1:69729950..69729959, -
3.07e-86FFCP PHASE2:Mm9::chr2:139885951..139885958,-#_5884893199fa68790cd27702941e5924p@chr2:139885951..139885958, -
3.07e-86FFCP PHASE1:Mm9::chr8:129378573..129378577,+#_5884893199fa68790cd27702941e5924p@chr8:129378573..129378577, +
3.07e-86FFCP PHASE1:Mm9::chr12:109240261..109240265,+#_5884893199fa68790cd27702941e5924p@chr12:109240261..109240265, +
3.07e-86FFCP PHASE1:Mm9::chr2:78812885..78812894,+#_5884893199fa68790cd27702941e5924p@chr2:78812885..78812894, +
3.07e-86FFCP PHASE2:Mm9::chr13:113079356..113079360,-#_5884893199fa68790cd27702941e5924p@chr13:113079356..113079360, -
3.07e-86FFCP PHASE1:Mm9::chr12:15821719..15821726,+#_5884893199fa68790cd27702941e5924p@chr12:15821719..15821726, +
3.07e-86FFCP PHASE1:Mm9::chr9:14707496..14707511,-#_5884893199fa68790cd27702941e5924p@chr9:14707496..14707511, -
3.07e-86FFCP PHASE1:Mm9::chr1:69727659..69727696,-#_5884893199fa68790cd27702941e5924p@chr1:69727659..69727696, -
3.07e-86FFCP PHASE2:Mm9::chr16:89837454..89837462,-#_5884893199fa68790cd27702941e5924p@chr16:89837454..89837462, -
3.07e-86FFCP PHASE2:Mm9::chr10:92842861..92842879,-#_5884893199fa68790cd27702941e5924p@chr10:92842861..92842879, -
3.07e-86FFCP PHASE1:Mm9::chr17:87518592..87518603,+#_5884893199fa68790cd27702941e5924p@chr17:87518592..87518603, +
3.07e-86FFCP PHASE1:Mm9::chr9:13699290..13699296,+#_5884893199fa68790cd27702941e5924p@chr9:13699290..13699296, +
3.07e-86FFCP PHASE1:Mm9::chr2:112347343..112347355,+#_5884893199fa68790cd27702941e5924p@chr2:112347343..112347355, +
3.07e-86FFCP PHASE1:Mm9::chr15:59357447..59357449,+#_5884893199fa68790cd27702941e5924p@chr15:59357447..59357449, +
3.07e-86FFCP PHASE1:Mm9::chr13:113079356..113079360,-#_5884893199fa68790cd27702941e5924p@chr13:113079356..113079360, -
3.07e-86FFCP PHASE1:Mm9::chr9:56267292..56267296,+#_5884893199fa68790cd27702941e5924p@chr9:56267292..56267296, +
3.07e-86FFCP PHASE2:Mm9::chr6:94615187..94615214,-#_5884893199fa68790cd27702941e5924p@chr6:94615187..94615214, -
3.07e-86FFCP PHASE1:Mm9::chr1:69815958..69815961,+#_5884893199fa68790cd27702941e5924p@chr1:69815958..69815961, +
3.07e-86FFCP PHASE2:Mm9::chr10:58784974..58784979,-#_5884893199fa68790cd27702941e5924p@chr10:58784974..58784979, -
3.07e-86FFCP PHASE2:Mm9::chr2:32306609..32306610,+#_5884893199fa68790cd27702941e5924p@chr2:32306609..32306610, +
3.07e-86FFCP PHASE2:Mm9::chrX:7154622..7154647,+#_5884893199fa68790cd27702941e5924p@chrX:7154622..7154647, +
3.07e-86FFCP PHASE2:Mm9::chr2:112347343..112347355,+#_5884893199fa68790cd27702941e5924p@chr2:112347343..112347355, +
3.07e-86FFCP PHASE2:Mm9::chr11:118084068..118084106,-#_5884893199fa68790cd27702941e5924p@chr11:118084068..118084106, -
3.07e-86FFCP PHASE2:Mm9::chr15:59357130..59357143,-#_5884893199fa68790cd27702941e5924p@chr15:59357130..59357143, -
3.07e-86FFCP PHASE2:Mm9::chr17:12807573..12807582,+#_5884893199fa68790cd27702941e5924p@chr17:12807573..12807582, +
3.07e-86FFCP PHASE1:Mm9::chr7:80757542..80757576,-#_5884893199fa68790cd27702941e5924p@chr7:80757542..80757576, -
3.07e-86FFCP PHASE1:Mm9::chr1:69729718..69729723,-#_5884893199fa68790cd27702941e5924p@chr1:69729718..69729723, -
3.07e-86FFCP PHASE2:Mm9::chr17:35164593..35164602,-#_5884893199fa68790cd27702941e5924p6@Ng23
3.07e-86FFCP PHASE2:Mm9::chr14:101876628..101876637,-#_5884893199fa68790cd27702941e5924p@chr14:101876628..101876637, -
3.07e-86FFCP PHASE2:Mm9::chr7:108729732..108729745,+#_5884893199fa68790cd27702941e5924p@chr7:108729732..108729745, +
3.07e-86FFCP PHASE1:Mm9::chr8:84303823..84303825,+#_5884893199fa68790cd27702941e5924p@chr8:84303823..84303825, +
3.07e-86FFCP PHASE2:Mm9::chr1:69727854..69727859,+#_5884893199fa68790cd27702941e5924p@chr1:69727854..69727859, +
3.07e-86FFCP PHASE2:Mm9::chr9:32530971..32530976,+#_5884893199fa68790cd27702941e5924p@chr9:32530971..32530976, +
3.07e-86FFCP PHASE2:Mm9::chr17:87518592..87518603,+#_5884893199fa68790cd27702941e5924p@chr17:87518592..87518603, +
3.07e-86FFCP PHASE2:Mm9::chr7:80757542..80757576,-#_5884893199fa68790cd27702941e5924p@chr7:80757542..80757576, -
3.07e-86FFCP PHASE2:Mm9::chr9:56267292..56267296,+#_5884893199fa68790cd27702941e5924p@chr9:56267292..56267296, +
3.07e-86FFCP PHASE2:Mm9::chr8:93597971..93597979,+#_5884893199fa68790cd27702941e5924p@chr8:93597971..93597979, +
3.07e-86FFCP PHASE1:Mm9::chr10:22022863..22022865,+#_5884893199fa68790cd27702941e5924p@chr10:22022863..22022865, +
3.07e-86FFCP PHASE2:Mm9::chrX:148215171..148215179,+#_5884893199fa68790cd27702941e5924p@chrX:148215171..148215179, +
3.07e-86FFCP PHASE2:Mm9::chrX:7172568..7172576,-#_5884893199fa68790cd27702941e5924p@chrX:7172568..7172576, -
3.07e-86FFCP PHASE1:Mm9::chr1:60967911..60967916,+#_5884893199fa68790cd27702941e5924p@chr1:60967911..60967916, +
3.07e-86FFCP PHASE2:Mm9::chr9:14662914..14662922,+#_5884893199fa68790cd27702941e5924p@chr9:14662914..14662922, +
3.07e-86FFCP PHASE1:Mm9::chrX:7148320..7148329,+#_5884893199fa68790cd27702941e5924p@chrX:7148320..7148329, +
3.07e-86FFCP PHASE1:Mm9::chr2:139885951..139885958,-#_5884893199fa68790cd27702941e5924p@chr2:139885951..139885958, -
3.07e-86FFCP PHASE2:Mm9::chr4:155396655..155396659,+#_5884893199fa68790cd27702941e5924p@chr4:155396655..155396659, +
3.07e-86FFCP PHASE2:Mm9::chrX:7161176..7161185,-#_5884893199fa68790cd27702941e5924p@chrX:7161176..7161185, -
3.07e-86FFCP PHASE1:Mm9::chr15:59354543..59354548,+#_5884893199fa68790cd27702941e5924p@chr15:59354543..59354548, +
3.07e-86FFCP PHASE2:Mm9::chr1:60970510..60970516,+#_5884893199fa68790cd27702941e5924p@chr1:60970510..60970516, +
3.07e-86FFCP PHASE1:Mm9::chrX:7172568..7172576,-#_5884893199fa68790cd27702941e5924p@chrX:7172568..7172576, -
3.07e-86FFCP PHASE1:Mm9::chr7:105641398..105641405,-#_5884893199fa68790cd27702941e5924p@chr7:105641398..105641405, -
3.07e-86FFCP PHASE1:Mm9::chr9:32530971..32530976,+#_5884893199fa68790cd27702941e5924p@chr9:32530971..32530976, +
3.07e-86FFCP PHASE2:Mm9::chr10:89010973..89010996,-#_5884893199fa68790cd27702941e5924p@chr10:89010973..89010996, -
3.07e-86FFCP PHASE2:Mm9::chr12:17040514..17040521,+#_5884893199fa68790cd27702941e5924p@chr12:17040514..17040521, +
3.07e-86FFCP PHASE1:Mm9::chr15:5504747..5504756,+#_5884893199fa68790cd27702941e5924p@chr15:5504747..5504756, +
3.07e-86FFCP PHASE1:Mm9::chr1:69727854..69727859,+#_5884893199fa68790cd27702941e5924p@chr1:69727854..69727859, +
3.07e-86FFCP PHASE1:Mm9::chr17:12884884..12884887,-#_5884893199fa68790cd27702941e5924p@chr17:12884884..12884887, -
3.07e-86FFCP PHASE1:Mm9::chr11:4397528..4397535,-#_5884893199fa68790cd27702941e5924p@chr11:4397528..4397535, -

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