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MCL coexpression mm9:884: Difference between revisions

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{{MCL_coexpression_mm9
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of protein kinase B;0.00542376595628116;108686!GO:0043422;protein kinase B binding;0.00542376595628116;108686!GO:0006259;DNA metabolic process;0.029822540857081;75339,108686!GO:0006275;regulation of DNA replication;0.029822540857081;108686!GO:0051052;regulation of DNA metabolic process;0.0356792078839629;108686!GO:0032147;activation of protein kinase activity;0.0356792078839629;108686!GO:0008017;microtubule binding;0.0356792078839629;108686!GO:0006261;DNA-dependent DNA replication;0.0356792078839629;108686!GO:0019901;protein kinase binding;0.0356792078839629;108686!GO:0019900;kinase binding;0.0356792078839629;108686!GO:0001932;regulation of protein amino acid phosphorylation;0.0356792078839629;108686!GO:0033238;regulation of amine metabolic process;0.0356792078839629;108686!GO:0006521;regulation of amino acid metabolic process;0.0356792078839629;108686!GO:0015631;tubulin binding;0.0356792078839629;108686!GO:0042325;regulation of phosphorylation;0.0356792078839629;108686!GO:0051174;regulation of phosphorus metabolic process;0.0356792078839629;108686!GO:0019220;regulation of phosphate metabolic process;0.0356792078839629;108686!GO:0045860;positive regulation of protein kinase activity;0.0470658445862631;108686!GO:0033674;positive regulation of kinase activity;0.0470658445862631;108686!GO:0051347;positive regulation of transferase activity;0.0470658445862631;108686!GO:0003682;chromatin binding;0.0470658445862631;75339!GO:0019219;regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;0.0470658445862631;75339,108686!GO:0031323;regulation of cellular metabolic process;0.0470658445862631;75339,108686!GO:0045859;regulation of protein kinase activity;0.0470658445862631;108686!GO:0019222;regulation of metabolic process;0.0470658445862631;75339,108686!GO:0006333;chromatin assembly or disassembly;0.0470658445862631;75339!GO:0043549;regulation of kinase 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|gostat_on_MCL_coexpression=GO:0032148;activation of protein kinase B;0.00542376595628116;108686!GO:0043422;protein kinase B binding;0.00542376595628116;108686!GO:0006259;DNA metabolic process;0.029822540857081;75339,108686!GO:0006275;regulation of DNA replication;0.029822540857081;108686!GO:0051052;regulation of DNA metabolic process;0.0356792078839629;108686!GO:0032147;activation of protein kinase activity;0.0356792078839629;108686!GO:0008017;microtubule binding;0.0356792078839629;108686!GO:0006261;DNA-dependent DNA replication;0.0356792078839629;108686!GO:0019901;protein kinase binding;0.0356792078839629;108686!GO:0019900;kinase binding;0.0356792078839629;108686!GO:0001932;regulation of protein amino acid phosphorylation;0.0356792078839629;108686!GO:0033238;regulation of amine metabolic process;0.0356792078839629;108686!GO:0006521;regulation of amino acid metabolic process;0.0356792078839629;108686!GO:0015631;tubulin binding;0.0356792078839629;108686!GO:0042325;regulation of phosphorylation;0.0356792078839629;108686!GO:0051174;regulation of phosphorus metabolic process;0.0356792078839629;108686!GO:0019220;regulation of phosphate metabolic process;0.0356792078839629;108686!GO:0045860;positive regulation of protein kinase activity;0.0470658445862631;108686!GO:0033674;positive regulation of kinase activity;0.0470658445862631;108686!GO:0051347;positive regulation of transferase activity;0.0470658445862631;108686!GO:0003682;chromatin binding;0.0470658445862631;75339!GO:0019219;regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;0.0470658445862631;75339,108686!GO:0031323;regulation of cellular metabolic process;0.0470658445862631;75339,108686!GO:0045859;regulation of protein kinase activity;0.0470658445862631;108686!GO:0019222;regulation of metabolic process;0.0470658445862631;75339,108686!GO:0006333;chromatin assembly or disassembly;0.0470658445862631;75339!GO:0043549;regulation of kinase activity;0.0470658445862631;108686!GO:0019899;enzyme binding;0.0470658445862631;108686!GO:0043085;positive regulation of catalytic activity;0.0470658445862631;108686!GO:0006260;DNA replication;0.0470658445862631;108686!GO:0051338;regulation of transferase activity;0.0470658445862631;108686!
|ontology_enrichment_celltype=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0010314!6.05e-09!92;UBERON:0000922!5.23e-08!320;UBERON:0002021!7.68e-08!10;UBERON:0000411!7.68e-08!10;UBERON:0001950!7.68e-08!10
|tfbs_overrepresentation_for_novel_motifs=0.393008,0.534222,0.367606,0.434198,0.260188,1.13872,0.538088,0.173246,0.535519,0.0447303,0.494602,0.526159,0.515774,0.550255,0.275867,0,0.742571,0.703873,0.160384,0.29826,1.58838,0.0622758,0.549359,0.717658,0.374936,0.577606,0.153291,0.469052,0.303071,0.376624,0.455168,0.843667,1.29258,0.839887,0.276324,0.60397,1.26012,0.522578,0.221921,0.195877,0.256422,0.460258,0.204736,0.27776,0.0824666,0.423266,0.662995,0.484612,0.0447507,0.305876,0.725127,0.604356,0.112729,0.985264,1.00271,0.557354,0.844204,0.513517,0.447041,0.555328,0.823643,0.613749,0.192045,0.713876,0.568415,0.754324,1.139,1.48833,0.818971,1.34113,0.349355,0.527912,0.0665967,1.03623,0.140213,0.409836,0.136938,0.651651,0.806481,0.336166,0.179489,0.759925,1.48701,0.968721,0.920903,0.025519,0.0299392,0.118251,0.667883,1.65055,1.20871,0.925879,0.856465,0.265734,0.218233,0.585369,0.1711,0.859272,0.663249,0.101559,0.679141,0.843387,0.967837,0.725721,0.724668,0.459825,0.784351,0.480639,0.903338,0.333829,0.386136,0.96962,0.337254,0.499714,1.21576,0.708441,0.143112,0.437894,0.743872,0.670977,1.04163,0.692953,1.41785,0.650748,1.26989,0.810177,0.546178,0.849691,1.13749,0.268537,0.950857,0.427043,1.10792,0.570914,1.23736,0.061199,0.401212,1.16726,1.18819,2.01886,1.6187,1.14372,0.591394,0.854131,0.718197,0.460705,0.666107,1.9792,1.04134,0.724779,0.120154,0.0553085,0.986833,0.207643,0.569994,1.06851,0.605358,0.287226,0.39061,0.400939,1.1977,0.920047,0.810622,0.383936,0.714896,0.562634,0.240994,0.524587,0.166768
|tfbs_overrepresentation_jaspar=MA0003.1;0.0545917,MA0004.1;0.434673,MA0006.1;0.271714,MA0007.1;0.419994,MA0009.1;0.870101,MA0014.1;0.012738,MA0017.1;0.296816,MA0019.1;0.688051,MA0024.1;0.826339,MA0025.1;1.10341,MA0027.1;2.51754,MA0028.1;0.281528,MA0029.1;0.804619,MA0030.1;0.811181,MA0031.1;0.775627,MA0038.1;0.577528,MA0040.1;0.882616,MA0041.1;0.360875,MA0042.1;0.348174,MA0043.1;0.966833,MA0046.1;0.906029,MA0048.1;1.13456,MA0050.1;0.472794,MA0051.1;0.586414,MA0052.1;0.890676,MA0055.1;0.523649,MA0056.1;0,MA0057.1;0.0935008,MA0058.1;0.341628,MA0059.1;0.353484,MA0060.1;0.197678,MA0061.1;0.638933,MA0063.1;0,MA0066.1;0.566617,MA0067.1;1.21448,MA0068.1;0.0965831,MA0069.1;0.891016,MA0070.1;0.881319,MA0071.1;0.471969,MA0072.1;0.872842,MA0073.1;1.1212e-05,MA0074.1;0.531046,MA0076.1;0.315013,MA0077.1;0.851175,MA0078.1;0.61926,MA0081.1;0.375851,MA0083.1;0.96604,MA0084.1;1.54225,MA0087.1;0.922929,MA0088.1;0.229377,MA0089.1;0,MA0090.1;0.401197,MA0091.1;0.447561,MA0092.1;0.401504,MA0093.1;0.289361,MA0095.1;0,MA0098.1;0,MA0100.1;0.519598,MA0101.1;0.362124,MA0103.1;0.307078,MA0105.1;0.133231,MA0106.1;0.626997,MA0107.1;0.301222,MA0108.2;0.710846,MA0109.1;0,MA0111.1;0.415012,MA0113.1;0.598933,MA0114.1;0.222763,MA0115.1;0.969632,MA0116.1;0.27152,MA0117.1;0.937363,MA0119.1;0.362692,MA0122.1;0.957212,MA0124.1;1.16127,MA0125.1;1.0872,MA0130.1;0,MA0131.1;0.683521,MA0132.1;0,MA0133.1;0,MA0135.1;1.00325,MA0136.1;0.550755,MA0139.1;0.169849,MA0140.1;0.519484,MA0141.1;0.325895,MA0142.1;0.761136,MA0143.1;1.49307,MA0144.1;0.225588,MA0145.1;0.527241,MA0146.1;0.198184,MA0147.1;0.236889,MA0148.1;0.450593,MA0149.1;0.367458,MA0062.2;0.137653,MA0035.2;0.524137,MA0039.2;0.00106576,MA0138.2;0.675599,MA0002.2;0.172399,MA0137.2;0.32312,MA0104.2;0.18504,MA0047.2;0.576767,MA0112.2;0.0701537,MA0065.2;0.0704227,MA0150.1;0.419883,MA0151.1;0,MA0152.1;0.576873,MA0153.1;1.01988,MA0154.1;0.100744,MA0155.1;0.0804339,MA0156.1;0.314185,MA0157.1;0.729116,MA0158.1;0,MA0159.1;0.246253,MA0160.1;0.453546,MA0161.1;0,MA0162.1;0.0211019,MA0163.1;0.0836563,MA0164.1;0.551114,MA0080.2;0.302064,MA0018.2;0.560731,MA0099.2;0.669311,MA0079.2;1.25307e-05,MA0102.2;1.59466,MA0258.1;0.210437,MA0259.1;0.227035,MA0442.1;0
}}

Latest revision as of 16:02, 17 September 2013


Phase1 CAGE Peaks

 Short description
Mm9::chr11:102342088..102342102,-p@chr11:102342088..102342102
-
Mm9::chr11:29363676..29363691,+p4@Ccdc88a
Mm9::chr11:29363735..29363749,+p3@Ccdc88a
Mm9::chr11:77107497..77107501,+p@chr11:77107497..77107501
+
Mm9::chr14:57291296..57291310,+p2@Mphosph8
Mm9::chr14:57292752..57292765,+p@chr14:57292752..57292765
+
Mm9::chr14:57293460..57293463,+p@chr14:57293460..57293463
+
Mm9::chr19:60018977..60019003,-p4@Rab11fip2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0032148activation of protein kinase B0.00542376595628116
GO:0043422protein kinase B binding0.00542376595628116
GO:0006259DNA metabolic process0.029822540857081
GO:0006275regulation of DNA replication0.029822540857081
GO:0051052regulation of DNA metabolic process0.0356792078839629
GO:0032147activation of protein kinase activity0.0356792078839629
GO:0008017microtubule binding0.0356792078839629
GO:0006261DNA-dependent DNA replication0.0356792078839629
GO:0019901protein kinase binding0.0356792078839629
GO:0019900kinase binding0.0356792078839629
GO:0001932regulation of protein amino acid phosphorylation0.0356792078839629
GO:0033238regulation of amine metabolic process0.0356792078839629
GO:0006521regulation of amino acid metabolic process0.0356792078839629
GO:0015631tubulin binding0.0356792078839629
GO:0042325regulation of phosphorylation0.0356792078839629
GO:0051174regulation of phosphorus metabolic process0.0356792078839629
GO:0019220regulation of phosphate metabolic process0.0356792078839629
GO:0045860positive regulation of protein kinase activity0.0470658445862631
GO:0033674positive regulation of kinase activity0.0470658445862631
GO:0051347positive regulation of transferase activity0.0470658445862631
GO:0003682chromatin binding0.0470658445862631
GO:0019219regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0470658445862631
GO:0031323regulation of cellular metabolic process0.0470658445862631
GO:0045859regulation of protein kinase activity0.0470658445862631
GO:0019222regulation of metabolic process0.0470658445862631
GO:0006333chromatin assembly or disassembly0.0470658445862631
GO:0043549regulation of kinase activity0.0470658445862631
GO:0019899enzyme binding0.0470658445862631
GO:0043085positive regulation of catalytic activity0.0470658445862631
GO:0006260DNA replication0.0470658445862631
GO:0051338regulation of transferase activity0.0470658445862631



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
structure with developmental contribution from neural crest6.05e-0992
embryo5.23e-08320
occipital lobe7.68e-0810
visual cortex7.68e-0810
neocortex7.68e-0810


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.10.0545917
MA0004.10.434673
MA0006.10.271714
MA0007.10.419994
MA0009.10.870101
MA0014.10.012738
MA0017.10.296816
MA0019.10.688051
MA0024.10.826339
MA0025.11.10341
MA0027.12.51754
MA0028.10.281528
MA0029.10.804619
MA0030.10.811181
MA0031.10.775627
MA0038.10.577528
MA0040.10.882616
MA0041.10.360875
MA0042.10.348174
MA0043.10.966833
MA0046.10.906029
MA0048.11.13456
MA0050.10.472794
MA0051.10.586414
MA0052.10.890676
MA0055.10.523649
MA0056.10
MA0057.10.0935008
MA0058.10.341628
MA0059.10.353484
MA0060.10.197678
MA0061.10.638933
MA0063.10
MA0066.10.566617
MA0067.11.21448
MA0068.10.0965831
MA0069.10.891016
MA0070.10.881319
MA0071.10.471969
MA0072.10.872842
MA0073.11.1212e-05
MA0074.10.531046
MA0076.10.315013
MA0077.10.851175
MA0078.10.61926
MA0081.10.375851
MA0083.10.96604
MA0084.11.54225
MA0087.10.922929
MA0088.10.229377
MA0089.10
MA0090.10.401197
MA0091.10.447561
MA0092.10.401504
MA0093.10.289361
MA0095.10
MA0098.10
MA0100.10.519598
MA0101.10.362124
MA0103.10.307078
MA0105.10.133231
MA0106.10.626997
MA0107.10.301222
MA0108.20.710846
MA0109.10
MA0111.10.415012
MA0113.10.598933
MA0114.10.222763
MA0115.10.969632
MA0116.10.27152
MA0117.10.937363
MA0119.10.362692
MA0122.10.957212
MA0124.11.16127
MA0125.11.0872
MA0130.10
MA0131.10.683521
MA0132.10
MA0133.10
MA0135.11.00325
MA0136.10.550755
MA0139.10.169849
MA0140.10.519484
MA0141.10.325895
MA0142.10.761136
MA0143.11.49307
MA0144.10.225588
MA0145.10.527241
MA0146.10.198184
MA0147.10.236889
MA0148.10.450593
MA0149.10.367458
MA0062.20.137653
MA0035.20.524137
MA0039.20.00106576
MA0138.20.675599
MA0002.20.172399
MA0137.20.32312
MA0104.20.18504
MA0047.20.576767
MA0112.20.0701537
MA0065.20.0704227
MA0150.10.419883
MA0151.10
MA0152.10.576873
MA0153.11.01988
MA0154.10.100744
MA0155.10.0804339
MA0156.10.314185
MA0157.10.729116
MA0158.10
MA0159.10.246253
MA0160.10.453546
MA0161.10
MA0162.10.0211019
MA0163.10.0836563
MA0164.10.551114
MA0080.20.302064
MA0018.20.560731
MA0099.20.669311
MA0079.21.25307e-05
MA0102.21.59466
MA0258.10.210437
MA0259.10.227035
MA0442.10
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