FFCP PHASE1:Hg19::chr12:28125659..28125672,-: Difference between revisions
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{{FFCP | {{FFCP|DPIdataset=robustDPI|EntrezGene=5744|GencodeV16b_All_Build2_RSEM10_CPAT_consensus=gencodeV16_protein_coding|HGNC=9607|TSSclassifier=N|UniProt=|association_with_transcript=-21bp_to_ENST00000545234_5end|coexpression_cluster_id=C268|description=CAGE_peak_1_at_PTHLH_5end|id=chr12:28125659..28125672,-|ontology_enrichment_celltype=CL:0002076!6.45e-16!43;CL:0002368!3.58e-15!13;CL:0002159!9.48e-13!13;CL:0000223!1.09e-09!59;CL:0002202!4.05e-09!9;CL:0002632!4.05e-09!9;CL:0000244!2.16e-08!4;CL:0000731!2.16e-08!4;CL:0002077!4.39e-08!33;CL:0000066!4.82e-07!254|ontology_enrichment_celltype_v019=CL:0002368;2.16e-22;13!CL:0002159;1.53e-20;14!CL:0002076;6.66e-19;42!CL:0000244;1.19e-13;4!CL:0000731;1.19e-13;4!CL:0002202;4.52e-12;9!CL:0002632;4.52e-12;9!CL:0002166;1.12e-10;3!CL:0002621;3.45e-10;3!CL:0000307;3.84e-10;3!CL:0002328;4.47e-10;3!CL:0002077;4.98e-09;34!CL:0002251;1.25e-08;20!CL:0000362;2.13e-08;9!CL:0000240;2.88e-08;6!CL:0000311;2.88e-08;6!CL:0000079;2.88e-08;6!CL:0000237;2.88e-08;6!CL:0000317;1.47e-07;2!CL:1000448;1.47e-07;2!CL:0002308;1.47e-07;2!CL:0002140;1.47e-07;2!CL:0000575;5.58e-07;2|ontology_enrichment_celltype_v019_2=CL:0002076,1.49e-24,42;CL:0002368,2.16e-22,13;CL:0002159,1.51e-20,14;CL:0000223,2.87e-16,58;CL:0000066,6.81e-15,253;CL:0000244,1.21e-13,4;CL:0000731,1.21e-13,4;CL:0002202,4.52e-12,9;CL:0002632,4.52e-12,9;CL:0002166,1.12e-10,3;CL:0002077,2.26e-10,34;CL:0002621,3.40e-10,3;CL:0000068,3.84e-10,3;CL:0000069,3.84e-10,3;CL:0000307,3.84e-10,3;CL:0000377,3.84e-10,3;CL:0002328,4.47e-10,3;CL:0002251,1.24e-08,20;CL:0000362,2.09e-08,9;CL:0000240,2.82e-08,6;CL:0000311,2.82e-08,6;CL:0000079,2.82e-08,6;CL:0000237,2.82e-08,6;CL:0000036,2.82e-08,6;CL:0000357,2.82e-08,6;CL:0000114,2.82e-08,6;CL:0000076,4.37e-08,63;CL:0002321,1.01e-07,250;CL:0000317,1.47e-07,2;CL:1000448,1.47e-07,2;CL:0002308,1.47e-07,2;CL:0002140,1.47e-07,2;CL:0000575,5.66e-07,2|ontology_enrichment_development_v019=CL:0000377;3.84e-10;3!CL:0000223;1.85e-09;58!CL:0000357;2.88e-08;6!CL:0000114;2.88e-08;6|ontology_enrichment_disease=|ontology_enrichment_disease_v019=DOID:1749;9.73e-12;14|ontology_enrichment_disease_v019_2=DOID:1749,9.22e-12,14|ontology_enrichment_uberon=UBERON:0001004!7.19e-10!72;UBERON:0000365!9.62e-10!5;UBERON:0004121!2.03e-09!169;UBERON:0000161!4.17e-09!35;UBERON:0000924!6.40e-09!173;UBERON:0006601!6.40e-09!173;UBERON:0007196!1.07e-08!14;UBERON:0001558!1.07e-08!14;UBERON:0007023!4.75e-08!115;UBERON:0005910!5.43e-08!6;UBERON:0000033!7.12e-08!123;UBERON:0004119!8.60e-08!169;UBERON:0000925!8.60e-08!169;UBERON:0006595!8.60e-08!169;UBERON:0000153!9.88e-08!129;UBERON:0007811!9.88e-08!129;UBERON:0003102!3.78e-07!95;UBERON:0000467!7.01e-07!625;UBERON:0000165!7.07e-07!28;UBERON:0000930!7.07e-07!28;UBERON:0000480!7.97e-07!626|ontology_enrichment_uberon_v019=UBERON:0000365;5.13e-16;5!UBERON:0000486;8.48e-16;12!UBERON:0005910;2.81e-13;6!UBERON:0001949;3.45e-10;3!UBERON:0004815;4.47e-10;3!UBERON:0002031;4.47e-10;3!UBERON:0005911;1.33e-09;36!UBERON:0007196;3.21e-09;15!UBERON:0001558;3.21e-09;15!UBERON:0001708;4.37e-08;4!UBERON:0008895;4.37e-08;4!UBERON:0003729;5.15e-08;13!UBERON:0010371;8.93e-08;31!UBERON:0002419;1.47e-07;2!UBERON:0007771;1.47e-07;2!UBERON:0003297;1.47e-07;2!UBERON:0001821;1.47e-07;2!UBERON:0003487;1.47e-07;2!UBERON:0001820;1.47e-07;2!UBERON:0003126;2.99e-07;7!UBERON:0001005;2.99e-07;7|ontology_enrichment_uberon_v019_2=UBERON:0000365,4.98e-16,5;UBERON:0005910,2.74e-13,6;UBERON:0001004,2.53e-11,74;UBERON:0004119,4.93e-11,160;UBERON:0000925,4.93e-11,160;UBERON:0006595,4.93e-11,160;UBERON:0001949,3.40e-10,3;UBERON:0003102,3.68e-10,99;UBERON:0004815,4.47e-10,3;UBERON:0002031,4.47e-10,3;UBERON:0007196,3.25e-09,15;UBERON:0001558,3.25e-09,15;UBERON:0010188,1.23e-08,6;UBERON:0002539,1.23e-08,6;UBERON:0008816,1.23e-08,6;UBERON:0001708,4.37e-08,4;UBERON:0008895,4.37e-08,4;UBERON:0003729,5.11e-08,13;UBERON:0000065,8.87e-08,54;UBERON:0002419,1.47e-07,2;UBERON:0007771,1.47e-07,2;UBERON:0003297,1.47e-07,2;UBERON:0001821,1.47e-07,2;UBERON:0003487,1.47e-07,2;UBERON:0001820,1.47e-07,2;UBERON:0005089,1.47e-07,2;UBERON:0005088,1.47e-07,2;UBERON:0000153,1.89e-07,62;UBERON:0007811,1.89e-07,62;UBERON:0000033,2.11e-07,56;UBERON:0003126,3.04e-07,7;UBERON:0001005,3.04e-07,7|phase1_expression=0,0,0,0,0,0,0,0,0,0.245733936501509,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.309632246632152,113.088810610908,156.62707776469,49.1772833521828,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,36.0652335409617,12.2358866118862,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.24406205754817,0,0,0,0,0,0,0,0,0,0,183.159501899864,0,0,0,0,0.354668382198357,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.125118519871964,0,0,0,0.150238058906597,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,65.9019509286842,461.486436039692,64.8178385579149,0,0,0.116193942869518,0,0.756962552626885,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,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| ||
|DPIdataset=robustDPI | |||
|EntrezGene=5744 | |||
|GencodeV16b_All_Build2_RSEM10_CPAT_consensus=gencodeV16_protein_coding | |||
|HGNC=9607 | |||
|TSSclassifier=N | |||
|UniProt= | |||
|association_with_transcript=-21bp_to_ENST00000545234_5end | |||
|coexpression_cluster_id=C268 | |||
|description=CAGE_peak_1_at_PTHLH_5end | |||
|id=chr12:28125659..28125672,- | |||
|ontology_enrichment_celltype=CL:0002076!6.45e-16!43;CL:0002368!3.58e-15!13;CL:0002159!9.48e-13!13;CL:0000223!1.09e-09!59;CL:0002202!4.05e-09!9;CL:0002632!4.05e-09!9;CL:0000244!2.16e-08!4;CL:0000731!2.16e-08!4;CL:0002077!4.39e-08!33;CL:0000066!4.82e-07!254 | |||
|ontology_enrichment_celltype_v019=CL:0002368;2.16e-22;13!CL:0002159;1.53e-20;14!CL:0002076;6.66e-19;42!CL:0000244;1.19e-13;4!CL:0000731;1.19e-13;4!CL:0002202;4.52e-12;9!CL:0002632;4.52e-12;9!CL:0002166;1.12e-10;3!CL:0002621;3.45e-10;3!CL:0000307;3.84e-10;3!CL:0002328;4.47e-10;3!CL:0002077;4.98e-09;34!CL:0002251;1.25e-08;20!CL:0000362;2.13e-08;9!CL:0000240;2.88e-08;6!CL:0000311;2.88e-08;6!CL:0000079;2.88e-08;6!CL:0000237;2.88e-08;6!CL:0000317;1.47e-07;2!CL:1000448;1.47e-07;2!CL:0002308;1.47e-07;2!CL:0002140;1.47e-07;2!CL:0000575;5.58e-07;2 | |||
|ontology_enrichment_celltype_v019_2=CL:0002076,1.49e-24,42;CL:0002368,2.16e-22,13;CL:0002159,1.51e-20,14;CL:0000223,2.87e-16,58;CL:0000066,6.81e-15,253;CL:0000244,1.21e-13,4;CL:0000731,1.21e-13,4;CL:0002202,4.52e-12,9;CL:0002632,4.52e-12,9;CL:0002166,1.12e-10,3;CL:0002077,2.26e-10,34;CL:0002621,3.40e-10,3;CL:0000068,3.84e-10,3;CL:0000069,3.84e-10,3;CL:0000307,3.84e-10,3;CL:0000377,3.84e-10,3;CL:0002328,4.47e-10,3;CL:0002251,1.24e-08,20;CL:0000362,2.09e-08,9;CL:0000240,2.82e-08,6;CL:0000311,2.82e-08,6;CL:0000079,2.82e-08,6;CL:0000237,2.82e-08,6;CL:0000036,2.82e-08,6;CL:0000357,2.82e-08,6;CL:0000114,2.82e-08,6;CL:0000076,4.37e-08,63;CL:0002321,1.01e-07,250;CL:0000317,1.47e-07,2;CL:1000448,1.47e-07,2;CL:0002308,1.47e-07,2;CL:0002140,1.47e-07,2;CL:0000575,5.66e-07,2 | |||
|ontology_enrichment_development_v019=CL:0000377;3.84e-10;3!CL:0000223;1.85e-09;58!CL:0000357;2.88e-08;6!CL:0000114;2.88e-08;6 | |||
|ontology_enrichment_disease= | |||
|ontology_enrichment_disease_v019=DOID:1749;9.73e-12;14 | |||
|ontology_enrichment_disease_v019_2=DOID:1749,9.22e-12,14 | |||
|ontology_enrichment_uberon=UBERON:0001004!7.19e-10!72;UBERON:0000365!9.62e-10!5;UBERON:0004121!2.03e-09!169;UBERON:0000161!4.17e-09!35;UBERON:0000924!6.40e-09!173;UBERON:0006601!6.40e-09!173;UBERON:0007196!1.07e-08!14;UBERON:0001558!1.07e-08!14;UBERON:0007023!4.75e-08!115;UBERON:0005910!5.43e-08!6;UBERON:0000033!7.12e-08!123;UBERON:0004119!8.60e-08!169;UBERON:0000925!8.60e-08!169;UBERON:0006595!8.60e-08!169;UBERON:0000153!9.88e-08!129;UBERON:0007811!9.88e-08!129;UBERON:0003102!3.78e-07!95;UBERON:0000467!7.01e-07!625;UBERON:0000165!7.07e-07!28;UBERON:0000930!7.07e-07!28;UBERON:0000480!7.97e-07!626 | |||
|ontology_enrichment_uberon_v019=UBERON:0000365;5.13e-16;5!UBERON:0000486;8.48e-16;12!UBERON:0005910;2.81e-13;6!UBERON:0001949;3.45e-10;3!UBERON:0004815;4.47e-10;3!UBERON:0002031;4.47e-10;3!UBERON:0005911;1.33e-09;36!UBERON:0007196;3.21e-09;15!UBERON:0001558;3.21e-09;15!UBERON:0001708;4.37e-08;4!UBERON:0008895;4.37e-08;4!UBERON:0003729;5.15e-08;13!UBERON:0010371;8.93e-08;31!UBERON:0002419;1.47e-07;2!UBERON:0007771;1.47e-07;2!UBERON:0003297;1.47e-07;2!UBERON:0001821;1.47e-07;2!UBERON:0003487;1.47e-07;2!UBERON:0001820;1.47e-07;2!UBERON:0003126;2.99e-07;7!UBERON:0001005;2.99e-07;7 | |||
|ontology_enrichment_uberon_v019_2=UBERON:0000365,4.98e-16,5;UBERON:0005910,2.74e-13,6;UBERON:0001004,2.53e-11,74;UBERON:0004119,4.93e-11,160;UBERON:0000925,4.93e-11,160;UBERON:0006595,4.93e-11,160;UBERON:0001949,3.40e-10,3;UBERON:0003102,3.68e-10,99;UBERON:0004815,4.47e-10,3;UBERON:0002031,4.47e-10,3;UBERON:0007196,3.25e-09,15;UBERON:0001558,3.25e-09,15;UBERON:0010188,1.23e-08,6;UBERON:0002539,1.23e-08,6;UBERON:0008816,1.23e-08,6;UBERON:0001708,4.37e-08,4;UBERON:0008895,4.37e-08,4;UBERON:0003729,5.11e-08,13;UBERON:0000065,8.87e-08,54;UBERON:0002419,1.47e-07,2;UBERON:0007771,1.47e-07,2;UBERON:0003297,1.47e-07,2;UBERON:0001821,1.47e-07,2;UBERON:0003487,1.47e-07,2;UBERON:0001820,1.47e-07,2;UBERON:0005089,1.47e-07,2;UBERON:0005088,1.47e-07,2;UBERON:0000153,1.89e-07,62;UBERON:0007811,1.89e-07,62;UBERON:0000033,2.11e-07,56;UBERON:0003126,3.04e-07,7;UBERON:0001005,3.04e-07,7 | |||
|phase1_expression=0,0,0,0,0,0,0,0,0,0.245733936501509,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.309632246632152,113.088810610908,156.62707776469,49.1772833521828,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,36.0652335409617,12.2358866118862,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.24406205754817,0,0,0,0,0,0,0,0,0,0,183.159501899864,0,0,0,0,0.354668382198357,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.125118519871964,0,0,0,0.150238058906597,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,65.9019509286842,461.486436039692,64.8178385579149,0,0,0.116193942869518,0,0.756962552626885,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,227.512341652081,6.74410519545717,6.73544115157927,137.679017950734,0,0,0,0.231860809950154,0,0,0,0,0,0,0,0,0,149.974134378843,891.649136479546,935.290316508024,0,0,0.383382679165211,0,0,0,0,0,0.063497894292169,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.167516265334349,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.184369168541703,0,0,0,0,0,0,1.21251028578504,0,0,0,0,0,0,0,0,0,0,0.177561725313127,0,0,0,0,378.957228873208,12.8913384510255,0,0,0.131124414959424,0,0,0,0,0,0,0,0.215915916102139,0,0,0,0,0,0,0,0,0,0,0,0.103041011647722,0,0,321.01443573986,169.015663969496,0,0,0,0,0,0,0,0,0,195.036200125954,131.842386212463,237.487257952421,15.8817715943213,0,0,0,0.308033580176089,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,9.99225307488266,0,0,0,2.26016233240486,1.65409603063837,0,0,0,0,0,1.239293992399,0,0,0,0,0,0,0,0,0,143.370947961013,142.104082413587,71.8680500084729,0.282431402330337,562.670522081297,220.697633124589,238.121992449195,461.284587615575,0,0,0,0,0,0,0,0,0,0,10.7817695031654,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8.35605696581915,0.296964680832639,0,0,0,0,0,0,0.398495976502139,0,0,1.43176155503017,0,0,0,0,0,0.0986434056369336,0,0,0,0.0927680981618513,0,0,0,3.62499787717397,6.25863965570248,0,0,0,0,0,0,0,0,0,0,0.219385397153973,0,0,0,0,0,0,0,1.27600463892768,0,1.5991043280559,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.802577647298789,0,0,0,0,0,0,0,0.063186579628488,0,0,0,0,0,0,0,0.554698692052555,0,4.40965788364699,0,0,0,0.0967563312890851,0,0,0,0,1.35588444468319,0,0,0.189932387867636,0,0.0801588202515337,18.9973165318024,24.7763915881841,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8.09918963689537,0.458320848023367,0.717873024576814,0.998395002494955,3.004582336956,0,0.335917362433631,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.182248669974074,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1.91502377331055,0,0,0,0,35.8083339450534,0,0,0,0,0.221858103073705,0.0620964029413835,0,13.2479232439833,0,0,0,0,0,0,0,0,0,0,0,0,0,0.15543720058278,0,0.318593534327405,0,0.776314784381297,0,0,0.521745061811734,0,0,2.44122439922797,0,0,0,0.796191777397232,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1.95831310807222,63.4518805233632,0,0,0,0,0,0,0,0,0,0,0,0,0,0.192687675289379,0,0,0,0,0.0691572524642179,0.322951291263702,0,0,112.071237180353,7.33714394086716,0,0,0,0,0.0752103283492573,0,0,0,0,0,0.202612753855184,0,0,0.19024743058172,0,0,0.496211178389294,0,0,2.67850917939143,0,0,0,0.177404740325278,0,0,0.135939465953663,0,0,8.23112374001312,0.078493092850514,0.314231179832004,0,0,2.15927591218621,0,0.0714765441766563,0,0,0,0,0.414432328326074,0,0,0,0.118332000730565,0.0852134047591577,0,0,0,0,0,0,0,0,0,0,2.4285549652957,0,0,0,87.8720518263109,0,0,0.0771741581079447,0,0,0.245148321753905,0,0,0,1.2679671827502,0,0,0,0,5.53517209677539,4.58763333230399,0,0,0.458729283404541,0,0,0.0679914901909147,0,0,0,0,0,0,0,0,0,0,0,0,0.151557396436479,0,0,0,10.661699095049,0,0,0,0,0,0,3.48346796635138,0.684466602170562,0.80822463617505,0.78894425931944,10.3124710529264,3.98876016193775,0,0,0,0,0,0,0,2.21401172950129,0 | |||
|short_description=p1@PTHLH | |||
}} |
Revision as of 22:21, 10 September 2013
Short description: | p1@PTHLH |
---|---|
Species: | Human (Homo sapiens) |
DPI dataset: | NA |
TSS-like-by-RIKEN-classifier(Yes/No): | NA |
DHS support(Yes/No): | NA |
Description: | CAGE_peak_1_at_PTHLH_5end |
Coexpression cluster: | C268_Mallassezderived_Urothelial_Gingival_Small_Bronchial_Tracheal_Prostate |
Association with transcript: | -21bp_to_ENST00000545234_5end |
EntrezGene: | PTHLH |
HGNC: | 9607 |
UniProt: | NA |
Genome view: | ZENBU |
View on UCSC genome browser
CAGE Expression
- Click each plot point to find sample in table
Ontology-based sample term enrichment analysis<b>Summary:</b>This analysis has been performed by utilizing wilcoxon rank sum test.When the number of associated cells/tissues are > n , randomly sampled n cells/tissues are used for P value calculation with rank sum test. this process are repeated several times, and the P values are averaged on the log space <br><b>Analyst:</b> Hideya Kawaji<br><br>link to source dataset<br>data
Ontology term | p-value | n |
---|---|---|
urothelium | 4.98e-16 | 5 |
transitional epithelium | 2.74e-13 | 6 |
respiratory system | 2.53e-11 | 74 |
endoderm-derived structure | 4.93e-11 | 160 |
endoderm | 4.93e-11 | 160 |
presumptive endoderm | 4.93e-11 | 160 |
gingival epithelium | 3.40e-10 | 3 |
surface structure | 3.68e-10 | 99 |
lower respiratory tract epithelium | 4.47e-10 | 3 |
epithelium of bronchus | 4.47e-10 | 3 |
tracheobronchial tree | 3.25e-09 | 15 |
lower respiratory tract | 3.25e-09 | 15 |
protuberance | 1.23e-08 | 6 |
pharyngeal arch | 1.23e-08 | 6 |
embryonic head | 1.23e-08 | 6 |
jaw skeleton | 4.37e-08 | 4 |
splanchnocranium | 4.37e-08 | 4 |
mouth mucosa | 5.11e-08 | 13 |
respiratory tract | 8.87e-08 | 54 |
skin gland | 1.47e-07 | 2 |
epidermis gland | 1.47e-07 | 2 |
gland of integumental system | 1.47e-07 | 2 |
sebaceous gland | 1.47e-07 | 2 |
skin sebaceous gland | 1.47e-07 | 2 |
sweat gland | 1.47e-07 | 2 |
sweat gland placode | 1.47e-07 | 2 |
sebaceous gland placode | 1.47e-07 | 2 |
anterior region of body | 1.89e-07 | 62 |
craniocervical region | 1.89e-07 | 62 |
head | 2.11e-07 | 56 |
trachea | 3.04e-07 | 7 |
respiratory airway | 3.04e-07 | 7 |
Ontology term | p-value | n |
---|---|---|
squamous cell carcinoma | 9.22e-12 | 14 |
Property "DHS support" (as page type) with input value "{{{DHSsupport}}}" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.