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Coexpression cluster:C1879: Difference between revisions

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|tfbs_overrepresentation_jaspar=MA0003.1;0.0497246,MA0004.1;0.626788,MA0006.1;1.14863,MA0007.1;1.47524,MA0009.1;1.11255,MA0014.1;0.0418333,MA0017.1;0.496101,MA0019.1;0.784036,MA0024.1;1.00439,MA0025.1;1.24931,MA0027.1;2.73598,MA0028.1;0.470679,MA0029.1;1.02437,MA0030.1;1.01252,MA0031.1;0.945567,MA0038.1;0.736268,MA0040.1;1.03042,MA0041.1;0.64667,MA0042.1;0.612397,MA0043.1;1.11288,MA0046.1;1.10134,MA0048.1;0.195817,MA0050.1;0.613347,MA0051.1;0.731787,MA0052.1;1.03442,MA0055.1;0.288856,MA0056.1;0,MA0057.1;0.189508,MA0058.1;0.523638,MA0059.1;1.29682,MA0060.1;0.321781,MA0061.1;0.291022,MA0063.1;0,MA0066.1;5.61971,MA0067.1;1.43651,MA0068.1;0.247962,MA0069.1;1.09737,MA0070.1;1.08584,MA0071.1;0.695094,MA0072.1;1.0812,MA0073.1;0.0469445,MA0074.1;0.730989,MA0076.1;0.540943,MA0077.1;1.07324,MA0078.1;0.836493,MA0081.1;0.522409,MA0083.1;1.12028,MA0084.1;1.62584,MA0087.1;1.07867,MA0088.1;0.818263,MA0089.1;0,MA0090.1;0.556637,MA0091.1;0.629594,MA0092.1;0.588959,MA0093.1;0.456342,MA0095.1;0,MA0098.1;0,MA0100.1;0.750974,MA0101.1;0.459973,MA0103.1;0.442769,MA0105.1;0.520776,MA0106.1;0.779931,MA0107.1;0.378225,MA0108.2;0.94238,MA0109.1;0,MA0111.1;0.5713,MA0113.1;0.797251,MA0114.1;1.72991,MA0115.1;1.35895,MA0116.1;1.76306,MA0117.1;1.1512,MA0119.1;1.25946,MA0122.1;1.17777,MA0124.1;1.31673,MA0125.1;1.23103,MA0130.1;0,MA0131.1;0.855546,MA0132.1;0,MA0133.1;0,MA0135.1;1.14377,MA0136.1;0.743749,MA0139.1;0.759606,MA0140.1;0.692258,MA0141.1;0.520334,MA0142.1;0.912455,MA0143.1;0.797437,MA0144.1;2.52629,MA0145.1;0.868598,MA0146.1;0.0359558,MA0147.1;0.386018,MA0148.1;0.653474,MA0149.1;0.681935,MA0062.2;0.284987,MA0035.2;0.691506,MA0039.2;0.0118463,MA0138.2;0.837782,MA0002.2;0.30855,MA0137.2;0.47779,MA0104.2;0.320919,MA0047.2;0.767096,MA0112.2;2.6393,MA0065.2;2.73531,MA0150.1;4.60032,MA0151.1;0,MA0152.1;0.69926,MA0153.1;1.21379,MA0154.1;0.172764,MA0155.1;1.91168,MA0156.1;0.480289,MA0157.1;0.883854,MA0158.1;0,MA0159.1;0.386729,MA0160.1;0.669748,MA0161.1;0,MA0162.1;0.0592265,MA0163.1;0.0439995,MA0164.1;0.810347,MA0080.2;0.456437,MA0018.2;0.781393,MA0099.2;0.699641,MA0079.2;0.00207114,MA0102.2;1.66336,MA0258.1;5.48354,MA0259.1;0.395396,MA0442.1;0
}}
}}

Revision as of 20:15, 22 January 2013


Full id: C1879_ovary_MCF7_breast_hepatocellular_uterus_epididymis_testis



Phase1 CAGE Peaks

Hg19::chr2:11679770..11679781,+p7@GREB1
Hg19::chr2:11679938..11679951,+p1@GREB1
Hg19::chr2:11680114..11680122,+p15@GREB1
Hg19::chr2:11680148..11680159,+p10@GREB1
Hg19::chr2:11680181..11680197,+p13@GREB1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
male reproductive organ9.22e-2011
male genital duct2.59e-193
internal male genitalia2.59e-193
adult organism3.18e-15114
duct of male reproductive system1.26e-144
male organism7.09e-1322
male reproductive system7.09e-1322
testis1.59e-128
reproductive organ3.42e-1148
reproductive structure1.17e-1059
reproductive system1.17e-1059
medulla oblongata7.01e-093
myelencephalon7.01e-093
future myelencephalon7.01e-093
internal genitalia1.82e-0825
uterus or analog7.03e-081
epididymis9.10e-081
seminal vesicle1.72e-071
seminal fluid secreting gland1.72e-071
vas deferens1.83e-071
spermatic cord1.83e-071
maxillary sinus2.35e-071
paranasal sinus2.35e-071
substantia nigra2.83e-071
midbrain nucleus2.83e-071
regional part of midbrain2.83e-071
midbrain2.83e-071
presumptive midbrain2.83e-071
midbrain neural tube2.83e-071
dura mater3.01e-071
future meninx3.01e-071
ectomeninx3.01e-071
future dura mater3.01e-071
gonad3.36e-0721
indifferent external genitalia3.36e-0721
indifferent gonad3.36e-0721
gonad primordium3.36e-0721
corpus callosum4.34e-071
central nervous system cell part cluster4.34e-071
axon tract4.34e-071
intercerebral commissure4.34e-071
dorsal telencephalic commissure4.34e-071
brain white matter4.34e-071
brain commissure4.34e-071
white matter4.34e-071
nervous system commissure4.34e-071
cerebral hemisphere white matter4.34e-071
nucleus accumbens4.61e-071
ventral striatum4.61e-071
external genitalia7.34e-0722
Disease
Ontology termp-valuen
thoracic cancer2.96e-154
breast cancer2.96e-154
paranasal sinus cancer2.35e-071
maxillary sinus cancer2.35e-071


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0497246
MA0004.10.626788
MA0006.11.14863
MA0007.11.47524
MA0009.11.11255
MA0014.10.0418333
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.195817
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.10.288856
MA0056.10
MA0057.10.189508
MA0058.10.523638
MA0059.11.29682
MA0060.10.321781
MA0061.10.291022
MA0063.10
MA0066.15.61971
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.0469445
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.818263
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.10.520776
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.11.72991
MA0115.11.35895
MA0116.11.76306
MA0117.11.1512
MA0119.11.25946
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.759606
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.12.52629
MA0145.10.868598
MA0146.10.0359558
MA0147.10.386018
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.20.0118463
MA0138.20.837782
MA0002.20.30855
MA0137.20.47779
MA0104.20.320919
MA0047.20.767096
MA0112.22.6393
MA0065.22.73531
MA0150.14.60032
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.172764
MA0155.11.91168
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.10.0592265
MA0163.10.0439995
MA0164.10.810347
MA0080.20.456437
MA0018.20.781393
MA0099.20.699641
MA0079.20.00207114
MA0102.21.66336
MA0258.15.48354
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BHLHE40#8553217.9487254187910.004747812859838950.0223198067729888
E2F1#186954.907389214879320.0003512818099256460.00353104147707647
EP300#203345.419153380978560.00209386927943890.0121213687531356
ESR1#2099530.76860329615453.62044058097993e-082.40991200660907e-06
FOXA1#3169511.08141974938555.98116883436141e-060.000179141752765091
FOXA2#3170524.63046375266521.10174651693954e-076.40675414714079e-06
HDAC2#3066513.41562023662632.29961139448262e-068.18014694919519e-05
HEY1#2346254.040111043105710.0009288852205177990.00674630344545608
HNF4A#3172523.13229036295371.50794906621644e-078.4808127370263e-06
HNF4G#3174211.50136901057870.01127438304921050.0413820654838157
NR3C1#290838.983813998703820.002687995788940450.0147979332771679
RXRA#6256312.044770283480.001145262162836830.0078366006043711
TBP#690853.706770687096390.001428755106721120.00919621315116771
TCF7L2#6934510.77017656313736.89693748574565e-060.000199919304488978



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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