MCL coexpression mm9:1420

Phase1 CAGE Peaks

	Short description
Mm9::chr19:5424822..5424845,-	p3@Drap1
Mm9::chr2:156301447..156301474,+	p5@Epb4.1l1
Mm9::chr2:156301539..156301570,+	p4@Epb4.1l1
Mm9::chr2:156301580..156301598,+	p3@Epb4.1l1
Mm9::chr2:32462499..32462577,+	p1@St6galnac6
Mm9::chr8:73397376..73397400,-	p1@Ccdc124

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	0.0197130614772321
GO:0001574	ganglioside biosynthetic process	0.0197130614772321
GO:0006688	glycosphingolipid biosynthetic process	0.0197130614772321
GO:0001573	ganglioside metabolic process	0.0197130614772321
GO:0030866	cortical actin cytoskeleton organization and biogenesis	0.0197130614772321
GO:0009247	glycolipid biosynthetic process	0.0197130614772321
GO:0030865	cortical cytoskeleton organization and biogenesis	0.0197130614772321
GO:0006687	glycosphingolipid metabolic process	0.0197130614772321
GO:0030148	sphingolipid biosynthetic process	0.0252244233060822
GO:0006664	glycolipid metabolic process	0.0252244233060822
GO:0008373	sialyltransferase activity	0.0286578341591222
GO:0006672	ceramide metabolic process	0.0302051664628912
GO:0046519	sphingoid metabolic process	0.0303028649509956
GO:0006665	sphingolipid metabolic process	0.0472284331056137

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
non-terminally differentiated cell	6.94e-09	49
neural cell	6.92e-07	43

Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	8.07e-20	54
nervous system	1.99e-19	75
central nervous system	4.02e-19	73
neural tube	2.21e-18	52
neural rod	2.21e-18	52
future spinal cord	2.21e-18	52
neural keel	2.21e-18	52
ectoderm-derived structure	3.39e-18	95
ectoderm	3.39e-18	95
presumptive ectoderm	3.39e-18	95
structure with developmental contribution from neural crest	2.27e-17	92
neurectoderm	2.74e-16	64
neural plate	2.74e-16	64
presumptive neural plate	2.74e-16	64
brain	5.27e-16	47
future brain	5.27e-16	47
regional part of brain	1.69e-15	46
ecto-epithelium	2.64e-15	73
gray matter	6.10e-13	34
anterior neural tube	4.79e-12	40
regional part of forebrain	1.88e-11	39
forebrain	1.88e-11	39
future forebrain	1.88e-11	39
pre-chordal neural plate	2.03e-11	49
brain grey matter	9.53e-11	29
regional part of telencephalon	9.53e-11	29
telencephalon	9.53e-11	29
cerebral cortex	4.78e-08	21
cerebral hemisphere	4.78e-08	21
pallium	4.78e-08	21
anatomical conduit	9.09e-08	122
posterior neural tube	1.79e-07	12
chordal neural plate	1.79e-07	12
regional part of cerebral cortex	2.20e-07	17
occipital lobe	2.79e-07	10
visual cortex	2.79e-07	10
neocortex	2.79e-07	10
tube	3.45e-07	114

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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