MCL coexpression mm9:1105

Phase1 CAGE Peaks

	Short description
Mm9::chr12:77634618..77634633,+	p2@Plekhg3
Mm9::chr2:102651988..102652001,-	p@chr2:102651988..102652001 -
Mm9::chr2:102653728..102653742,-	p@chr2:102653728..102653742 -
Mm9::chr2:102654028..102654039,-	p@chr2:102654028..102654039 -
Mm9::chr2:102654078..102654085,-	p@chr2:102654078..102654085 -
Mm9::chr2:102701761..102701783,-	p@chr2:102701761..102701783 -
Mm9::chr2:102741606..102741622,-	p1@Cd44

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0002246	healing during inflammatory response	0.00690297485344875
GO:0005540	hyaluronic acid binding	0.0344354514796465
GO:0001658	ureteric bud branching	0.0344354514796465
GO:0001657	ureteric bud development	0.0344354514796465
GO:0001656	metanephros development	0.0344354514796465
GO:0005089	Rho guanyl-nucleotide exchange factor activity	0.0344354514796465
GO:0035023	regulation of Rho protein signal transduction	0.0344354514796465
GO:0048754	branching morphogenesis of a tube	0.0344354514796465
GO:0005088	Ras guanyl-nucleotide exchange factor activity	0.0344354514796465
GO:0001763	morphogenesis of a branching structure	0.0344354514796465
GO:0001822	kidney development	0.0344354514796465
GO:0005539	glycosaminoglycan binding	0.0344354514796465
GO:0001655	urogenital system development	0.0344354514796465
GO:0042060	wound healing	0.0344354514796465
GO:0007266	Rho protein signal transduction	0.0344354514796465
GO:0030247	polysaccharide binding	0.0344354514796465
GO:0001871	pattern binding	0.0344354514796465
GO:0046578	regulation of Ras protein signal transduction	0.0382458542655602
GO:0005085	guanyl-nucleotide exchange factor activity	0.0429970388807503
GO:0051056	regulation of small GTPase mediated signal transduction	0.0429970388807503
GO:0009897	external side of plasma membrane	0.043252751891532
GO:0035239	tube morphogenesis	0.043252751891532
GO:0007265	Ras protein signal transduction	0.043252751891532
GO:0005083	small GTPase regulator activity	0.043252751891532

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
musculoskeletal system	1.95e-10	32
bone element	4.74e-07	22
skeletal element	4.74e-07	22
skeletal system	4.74e-07	22
bone marrow	6.03e-07	16

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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