MCL coexpression mm9:1081

Phase1 CAGE Peaks

	Short description
Mm9::chr11:59653305..59653320,-	p2@Cops3
Mm9::chr11:59653330..59653345,-	p3@Cops3
Mm9::chr1:10028013..10028049,-	p1@Cops5
Mm9::chr1:83311026..83311046,+	p1@ENSMUST00000110799 p1@ENSMUST00000159051
Mm9::chr1:95375362..95375400,-	p2@Hdlbp
Mm9::chr2:90894420..90894460,+	p2@Psmc3
Mm9::chr4:118842570..118842574,-	p@chr4:118842570..118842574 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0008180	signalosome	0.00012312337623569
GO:0001701	in utero embryonic development	0.0119099506353932
GO:0043009	chordate embryonic development	0.02102104430441
GO:0009792	embryonic development ending in birth or egg hatching	0.02102104430441
GO:0005634	nucleus	0.036803317170155
GO:0043234	protein complex	0.036803317170155
GO:0009790	embryonic development	0.047157877500016

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

---

Uber Anatomy

Ontology term	p-value	n
epithelial tube	1.90e-09	47
primary circulatory organ	1.49e-07	18
heart	1.49e-07	18
primitive heart tube	1.49e-07	18
primary heart field	1.49e-07	18
anterior lateral plate mesoderm	1.49e-07	18
heart tube	1.49e-07	18
heart primordium	1.49e-07	18
cardiac mesoderm	1.49e-07	18
cardiogenic plate	1.49e-07	18
heart rudiment	1.49e-07	18
cardiovascular system	1.79e-07	23
circulatory system	1.79e-07	23
multi-cellular organism	6.21e-07	333

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}