MCL coexpression mm9:618

Phase1 CAGE Peaks

	Short description
Mm9::chr14:67853568..67853573,+	p5@Ebf2
Mm9::chr16:7039662..7039675,+	p@chr16:7039662..7039675 +
Mm9::chr7:144387481..144387486,-	p@chr7:144387481..144387486 -
Mm9::chr7:144388046..144388053,-	p@chr7:144388046..144388053 -
Mm9::chr7:144505876..144505884,-	p9@Ebf3
Mm9::chr7:144505906..144505913,-	p7@Ebf3
Mm9::chr7:144505942..144505949,-	p10@Ebf3
Mm9::chr7:144505957..144505972,-	p2@Ebf3
Mm9::chr7:144505980..144506010,-	p3@Ebf3
Mm9::chr7:144506051..144506062,-	p5@Ebf3
Mm9::chr7:144506077..144506128,-	p1@Ebf3
Mm9::chr7:144514443..144514468,-	p@chr7:144514443..144514468 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0045941	positive regulation of transcription	0.00456059693951042
GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.00456059693951042
GO:0031325	positive regulation of cellular metabolic process	0.00456059693951042
GO:0009893	positive regulation of metabolic process	0.00456059693951042
GO:0048522	positive regulation of cellular process	0.0139460471818904
GO:0048518	positive regulation of biological process	0.0154899199155359
GO:0006355	regulation of transcription, DNA-dependent	0.0349260642094763
GO:0006351	transcription, DNA-dependent	0.0349260642094763
GO:0032774	RNA biosynthetic process	0.0349260642094763
GO:0008270	zinc ion binding	0.0349260642094763
GO:0003677	DNA binding	0.0349260642094763
GO:0045449	regulation of transcription	0.0349260642094763
GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0349260642094763
GO:0006350	transcription	0.0349260642094763
GO:0010468	regulation of gene expression	0.0349260642094763
GO:0031323	regulation of cellular metabolic process	0.0349260642094763
GO:0007275	multicellular organismal development	0.0349260642094763
GO:0019222	regulation of metabolic process	0.0349260642094763
GO:0016070	RNA metabolic process	0.0349260642094763
GO:0046914	transition metal ion binding	0.0349696642771753
GO:0010467	gene expression	0.0452542399071736
GO:0003676	nucleic acid binding	0.0453069182867025
GO:0032502	developmental process	0.0461573716705461
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0482336750242131

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	1.31e-08	23
neuroblast (sensu Vertebrata)	1.31e-08	23

Uber Anatomy

Ontology term	p-value	n
spinal cord	5.24e-07	6
dorsal region element	5.24e-07	6
dorsum	5.24e-07	6

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}