MCL coexpression mm9:433

Phase1 CAGE Peaks

	Short description
Mm9::chr10:120416369..120416378,-	p@chr10:120416369..120416378 -
Mm9::chr12:4925036..4925055,-	p@chr12:4925036..4925055 -
Mm9::chr16:17722647..17722693,+	p@chr16:17722647..17722693 +
Mm9::chr17:17511579..17511588,+	p@chr17:17511579..17511588 +
Mm9::chr17:29626018..29626030,-	p@chr17:29626018..29626030 -
Mm9::chr17:29626283..29626293,+	p@chr17:29626283..29626293 +
Mm9::chr19:36423777..36423809,-	p@chr19:36423777..36423809 -
Mm9::chr2:56976467..56976482,-	p4@Nr4a2
Mm9::chr4:102244812..102244831,-	p@chr4:102244812..102244831 -
Mm9::chr4:102244969..102244982,+	p@chr4:102244969..102244982 +
Mm9::chr7:25155202..25155218,+	p8@Kcnn4
Mm9::chr7:26465861..26465880,+	p2@B9d2
Mm9::chr7:87546167..87546184,+	p@chr7:87546167..87546184 +
Mm9::chr9:75255861..75255886,+	p@chr9:75255861..75255886 +
Mm9::chr9:75255893..75255906,+	p@chr9:75255893..75255906 +
Mm9::chr9:75256131..75256135,+	p@chr9:75256131..75256135 +
Mm9::chrX:101176473..101176487,-	p3@Rlim

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0046541	saliva secretion	0.0456920771900011
GO:0050714	positive regulation of protein secretion	0.0456920771900011
GO:0042069	regulation of catecholamine metabolic process	0.0456920771900011
GO:0042053	regulation of dopamine metabolic process	0.0456920771900011
GO:0051047	positive regulation of secretion	0.0456920771900011
GO:0007589	fluid secretion	0.0456920771900011
GO:0015269	calcium-activated potassium channel activity	0.0456920771900011
GO:0022600	digestive system process	0.0456920771900011
GO:0022839	ion gated channel activity	0.0456920771900011
GO:0005227	calcium activated cation channel activity	0.0456920771900011
GO:0050708	regulation of protein secretion	0.0456920771900011

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
hematopoietic cell	5.50e-30	32
hematopoietic oligopotent progenitor cell	5.50e-30	32
hematopoietic stem cell	5.50e-30	32
angioblastic mesenchymal cell	5.50e-30	32
hematopoietic multipotent progenitor cell	5.50e-30	32
lymphoid lineage restricted progenitor cell	5.82e-30	12
lymphocyte	1.83e-27	13
common lymphoid progenitor	1.83e-27	13
T cell	1.86e-27	11
pro-T cell	1.86e-27	11
mature alpha-beta T cell	3.91e-23	9
alpha-beta T cell	3.91e-23	9
immature T cell	3.91e-23	9
mature T cell	3.91e-23	9
immature alpha-beta T cell	3.91e-23	9
nucleate cell	7.68e-22	16
connective tissue cell	8.89e-22	46
mesenchymal cell	8.89e-22	46
motile cell	1.18e-21	54
CD4-positive, alpha-beta T cell	9.72e-21	8
leukocyte	2.08e-20	17
nongranular leukocyte	2.08e-20	17
hematopoietic lineage restricted progenitor cell	7.06e-18	25
stem cell	1.21e-16	97
thymocyte	6.40e-16	6
double negative thymocyte	6.40e-16	6
naive T cell	6.40e-16	6
double-positive, alpha-beta thymocyte	6.40e-16	6
CD4-positive, alpha-beta thymocyte	6.40e-16	6
naive thymus-derived CD4-positive, alpha-beta T cell	6.40e-16	6
DN4 thymocyte	6.40e-16	6
DN1 thymic pro-T cell	6.40e-16	6
DN2 thymocyte	6.40e-16	6
DN3 thymocyte	6.40e-16	6
immature single positive thymocyte	6.40e-16	6
early T lineage precursor	6.40e-16	6
mature CD4 single-positive thymocyte	6.40e-16	6
resting double-positive thymocyte	6.40e-16	6
double-positive blast	6.40e-16	6
CD69-positive double-positive thymocyte	6.40e-16	6
CD69-positive, CD4-positive single-positive thymocyte	6.40e-16	6
CD4-positive, CD8-intermediate double-positive thymocyte	6.40e-16	6
CD24-positive, CD4 single-positive thymocyte	6.40e-16	6
somatic stem cell	2.14e-13	91
multi fate stem cell	2.14e-13	91
somatic cell	3.66e-12	118
animal cell	2.69e-09	115
eukaryotic cell	2.69e-09	115
common myeloid progenitor	2.95e-08	19
barrier cell	4.38e-08	3

Uber Anatomy

Ontology term	p-value	n
connective tissue	8.89e-22	46

Disease

Ontology term	p-value	n
musculoskeletal system cancer	1.34e-08	3
muscle cancer	1.34e-08	3

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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