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Coexpression cluster:C813: Difference between revisions

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|gostat_on_coexpression_clusters=GO:0004558!alpha-glucosidase activity!0.0453431196630803!2595$GO:0045843!negative regulation of striated muscle development!0.0453431196630803!9734$GO:0032488!Cdc42 protein signal transduction!0.0453431196630803!221472$GO:0043088!regulation of Cdc42 GTPase activity!0.0453431196630803!221472$GO:0032489!regulation of Cdc42 protein signal transduction!0.0453431196630803!221472$GO:0032319!regulation of Rho GTPase activity!0.0453431196630803!221472$GO:0016202!regulation of striated muscle development!0.0453431196630803!9734$GO:0016566!specific transcriptional repressor activity!0.0453431196630803!9734$GO:0015926!glucosidase activity!0.0453431196630803!2595
|gostat_on_coexpression_clusters=GO:0004558!alpha-glucosidase activity!0.0453431196630803!2595$GO:0045843!negative regulation of striated muscle development!0.0453431196630803!9734$GO:0032488!Cdc42 protein signal transduction!0.0453431196630803!221472$GO:0043088!regulation of Cdc42 GTPase activity!0.0453431196630803!221472$GO:0032489!regulation of Cdc42 protein signal transduction!0.0453431196630803!221472$GO:0032319!regulation of Rho GTPase activity!0.0453431196630803!221472$GO:0016202!regulation of striated muscle development!0.0453431196630803!9734$GO:0016566!specific transcriptional repressor activity!0.0453431196630803!9734$GO:0015926!glucosidase activity!0.0453431196630803!2595
|id=C813
|id=C813
|ontology_enrichment_celltype=CL:0000738!3.29e-56!140;CL:0000037!2.61e-53!172;CL:0000566!2.61e-53!172;CL:0002087!2.30e-49!119;CL:0002032!3.29e-49!165;CL:0000837!3.29e-49!165;CL:0002031!1.25e-47!124;CL:0000988!3.42e-46!182;CL:0000766!2.30e-31!76;CL:0000557!3.93e-31!71;CL:0002009!1.61e-30!65;CL:0000763!1.07e-29!112;CL:0000049!1.07e-29!112;CL:0002194!2.13e-29!63;CL:0000576!2.13e-29!63;CL:0000040!2.13e-29!63;CL:0000559!2.13e-29!63;CL:0000839!1.87e-28!70;CL:0002057!1.71e-23!42;CL:0000860!1.10e-22!45;CL:0000542!3.29e-17!53;CL:0000051!3.29e-17!53;CL:0000838!6.89e-17!52;CL:0000945!2.58e-12!24;CL:0000826!2.58e-12!24;CL:0000236!1.84e-09!14;CL:0000134!7.17e-09!358;CL:0002320!7.09e-08!365;CL:0000451!2.78e-07!10;CL:0002393!4.08e-07!9;CL:0002397!4.08e-07!9
|ontology_enrichment_celltype=CL:0000738!1.17e-72!136;CL:0002087!1.01e-65!115;CL:0000037!1.19e-65!168;CL:0000566!1.19e-65!168;CL:0002032!9.34e-61!161;CL:0000837!9.34e-61!161;CL:0002031!1.94e-60!120;CL:0000988!6.63e-60!177;CL:0002009!2.58e-49!61;CL:0002194!2.11e-47!59;CL:0000576!2.11e-47!59;CL:0000040!2.11e-47!59;CL:0000559!2.11e-47!59;CL:0000557!2.88e-47!67;CL:0000766!5.82e-47!72;CL:0000839!1.94e-42!66;CL:0000763!3.82e-41!108;CL:0000049!3.82e-41!108;CL:0000473!4.54e-41!48;CL:0000234!4.54e-41!48;CL:0000860!4.76e-36!42;CL:0002057!4.76e-36!42;CL:0000945!5.78e-20!24;CL:0000826!5.78e-20!24;CL:0000542!1.18e-16!53;CL:0000051!1.18e-16!53;CL:0000838!4.61e-16!52;CL:0002242!1.49e-15!55;CL:0000236!1.78e-14!14;CL:0000325!3.32e-14!87;CL:0000451!3.52e-11!10;CL:0002393!2.44e-10!9;CL:0002397!2.44e-10!9;CL:0000134!2.68e-10!354;CL:0002320!1.84e-09!361;CL:0000990!3.39e-09!8;CL:0000840!2.31e-07!5;CL:0001029!2.31e-07!5
|ontology_enrichment_disease=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0002390!1.49e-35!102;UBERON:0003061!1.49e-35!102;UBERON:0002193!2.15e-32!112;UBERON:0007023!3.81e-28!115;UBERON:0002371!1.29e-26!80;UBERON:0001474!3.22e-23!86;UBERON:0002405!2.18e-20!115;UBERON:0004765!4.14e-19!101;UBERON:0001434!4.14e-19!101;UBERON:0001049!1.11e-07!57;UBERON:0005068!1.11e-07!57;UBERON:0006241!1.11e-07!57;UBERON:0007135!1.11e-07!57;UBERON:0000178!1.80e-07!15;UBERON:0000179!1.80e-07!15;UBERON:0000463!1.80e-07!15;UBERON:0002384!4.80e-07!375;UBERON:0003080!6.33e-07!42
|ontology_enrichment_uberon=UBERON:0002390!4.80e-51!98;UBERON:0003061!4.80e-51!98;UBERON:0002193!1.54e-46!108;UBERON:0002371!1.91e-41!76;UBERON:0002405!1.74e-38!93;UBERON:0001474!1.60e-36!82;UBERON:0004765!4.97e-31!90;UBERON:0001434!1.78e-26!100;UBERON:0007023!1.91e-24!114;UBERON:0003081!1.66e-14!203;UBERON:0002384!1.07e-08!371;UBERON:0002204!1.07e-08!167;UBERON:0000178!1.81e-08!15;UBERON:0000179!1.81e-08!15;UBERON:0000463!1.81e-08!15
|tf_chipseq_enrich=EBF1#1879;5:4.4532334232845:0.00275908025703869:0.0151278655483444!IRF4#3662;4:8.76580507469765:0.00072866783536506:0.00580970608883819!NFKB1#4790;6:3.2928380545163:0.0039127525205927:0.0190696700965132!SPI1#6688;6:4.92259410511364:0.000443419790230525:0.00412858335311454!SRF#6722;4:5.51887130486712:0.00405805946662648:0.019413662802208
|tf_chipseq_enrich=EBF1#1879;5:4.4532334232845:0.00275908025703869:0.0151278655483444!IRF4#3662;4:8.76580507469765:0.00072866783536506:0.00580970608883819!NFKB1#4790;6:3.2928380545163:0.0039127525205927:0.0190696700965132!SPI1#6688;6:4.92259410511364:0.000443419790230525:0.00412858335311454!SRF#6722;4:5.51887130486712:0.00405805946662648:0.019413662802208
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}}
}}

Revision as of 16:44, 19 October 2012


Full id: C813_CD19_CD14CD16_CD14_Macrophage_Monocytederived_pancreatic_choriocarcinoma



Phase1 CAGE Peaks

Hg19::chr12:109027413..109027428,-p@chr12:109027413..109027428
-
Hg19::chr15:42566384..42566475,+p2@GANC
Hg19::chr19:3178856..3178869,+p3@S1PR4
Hg19::chr1:198609269..198609281,+p@chr1:198609269..198609281
+
Hg19::chr3:46968478..46968499,-p@chr3:46968478..46968499
-
Hg19::chr4:164534657..164534701,-p1@MARCH1
Hg19::chr5:122110718..122110800,+p1@SNX2
Hg19::chr6:36973462..36973468,+p2@FGD2
Hg19::chr6:36973470..36973478,+p3@FGD2
Hg19::chr7:18330064..18330080,+p3@HDAC9


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0004558alpha-glucosidase activity0.0453431196630803
GO:0045843negative regulation of striated muscle development0.0453431196630803
GO:0032488Cdc42 protein signal transduction0.0453431196630803
GO:0043088regulation of Cdc42 GTPase activity0.0453431196630803
GO:0032489regulation of Cdc42 protein signal transduction0.0453431196630803
GO:0032319regulation of Rho GTPase activity0.0453431196630803
GO:0016202regulation of striated muscle development0.0453431196630803
GO:0016566specific transcriptional repressor activity0.0453431196630803
GO:0015926glucosidase activity0.0453431196630803



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte1.17e-72136
nongranular leukocyte1.01e-65115
hematopoietic stem cell1.19e-65168
angioblastic mesenchymal cell1.19e-65168
hematopoietic oligopotent progenitor cell9.34e-61161
hematopoietic multipotent progenitor cell9.34e-61161
hematopoietic lineage restricted progenitor cell1.94e-60120
hematopoietic cell6.63e-60177
macrophage dendritic cell progenitor2.58e-4961
monopoietic cell2.11e-4759
monocyte2.11e-4759
monoblast2.11e-4759
promonocyte2.11e-4759
granulocyte monocyte progenitor cell2.88e-4767
myeloid leukocyte5.82e-4772
myeloid lineage restricted progenitor cell1.94e-4266
myeloid cell3.82e-41108
common myeloid progenitor3.82e-41108
defensive cell4.54e-4148
phagocyte4.54e-4148
classical monocyte4.76e-3642
CD14-positive, CD16-negative classical monocyte4.76e-3642
lymphocyte of B lineage5.78e-2024
pro-B cell5.78e-2024
lymphocyte1.18e-1653
common lymphoid progenitor1.18e-1653
lymphoid lineage restricted progenitor cell4.61e-1652
nucleate cell1.49e-1555
B cell1.78e-1414
stuff accumulating cell3.32e-1487
dendritic cell3.52e-1110
intermediate monocyte2.44e-109
CD14-positive, CD16-positive monocyte2.44e-109
mesenchymal cell2.68e-10354
connective tissue cell1.84e-09361
conventional dendritic cell3.39e-098
immature conventional dendritic cell2.31e-075
common dendritic progenitor2.31e-075
Uber Anatomy
Ontology termp-valuen
hematopoietic system4.80e-5198
blood island4.80e-5198
hemolymphoid system1.54e-46108
bone marrow1.91e-4176
immune system1.74e-3893
bone element1.60e-3682
skeletal element4.97e-3190
skeletal system1.78e-26100
adult organism1.91e-24114
lateral plate mesoderm1.66e-14203
connective tissue1.07e-08371
musculoskeletal system1.07e-08167
blood1.81e-0815
haemolymphatic fluid1.81e-0815
organism substance1.81e-0815


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EBF1#187954.45323342328450.002759080257038690.0151278655483444
IRF4#366248.765805074697650.000728667835365060.00580970608883819
NFKB1#479063.29283805451630.00391275252059270.0190696700965132
SPI1#668864.922594105113640.0004434197902305250.00412858335311454
SRF#672245.518871304867120.004058059466626480.019413662802208



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.