Coexpression cluster:C202

Full id: C202_salivary_skin_penis_tongue_uterus_cervical_immature

Phase1 CAGE Peaks

Hg19::chr10:134756449..134756462,+	p@chr10:134756449..134756462 +
Hg19::chr10:30847379..30847383,-	p@chr10:30847379..30847383 -
Hg19::chr10:47740297..47740299,+	p1@FAM25HP
Hg19::chr11:34218778..34218792,+	p@chr11:34218778..34218792 +
Hg19::chr11:85195171..85195180,+	p@chr11:85195171..85195180 +
Hg19::chr11:86285462..86285463,-	p@chr11:86285462..86285463 -
Hg19::chr12:110318334..110318354,-	p2@GLTP
Hg19::chr12:53070961..53070973,-	p@chr12:53070961..53070973 -
Hg19::chr12:53074182..53074197,-	p1@KRT1
Hg19::chr12:53171128..53171131,-	p1@KRT76
Hg19::chr15:28560796..28560799,+	p1@ENST00000544920
Hg19::chr16:70597904..70597915,+	p5@SF3B3
Hg19::chr17:38261177..38261211,-	p@chr17:38261177..38261211 -
Hg19::chr17:38975796..38975805,-	p13@KRT10
Hg19::chr17:38975820..38975830,-	p10@KRT10
Hg19::chr17:38975839..38975846,-	p14@KRT10
Hg19::chr17:38975850..38975854,-	p19@KRT10
Hg19::chr17:38975877..38975899,-	p4@KRT10
Hg19::chr17:38975907..38975928,-	p3@KRT10
Hg19::chr17:38976407..38976413,-	p20@KRT10
Hg19::chr17:38976601..38976615,-	p@chr17:38976601..38976615 -
Hg19::chr17:38976637..38976653,-	p@chr17:38976637..38976653 -
Hg19::chr17:38976811..38976823,-	p@chr17:38976811..38976823 -
Hg19::chr17:38976838..38976861,-	p@chr17:38976838..38976861 -
Hg19::chr17:38976882..38976895,-	p@chr17:38976882..38976895 -
Hg19::chr17:38976909..38976919,-	p@chr17:38976909..38976919 -
Hg19::chr17:38977317..38977333,-	p@chr17:38977317..38977333 -
Hg19::chr17:38977346..38977362,-	p@chr17:38977346..38977362 -
Hg19::chr17:38977367..38977371,-	p@chr17:38977367..38977371 -
Hg19::chr17:38978257..38978272,-	p6@KRT10
Hg19::chr17:38978288..38978293,-	p21@KRT10
Hg19::chr17:38978422..38978432,-	p12@KRT10
Hg19::chr17:38978519..38978529,-	p9@KRT10
Hg19::chr17:38978526..38978535,+	p@chr17:38978526..38978535 +
Hg19::chr17:38978586..38978620,-	p5@KRT10
Hg19::chr17:38978621..38978636,-	p8@KRT10
Hg19::chr17:38978676..38978690,-	p3@AB590331
Hg19::chr17:38978718..38978740,-	p1@AB590331
Hg19::chr17:38978741..38978756,-	p2@AB590331
Hg19::chr17:38978856..38978875,-	p1@KRT10
Hg19::chr17:995196..995215,-	p22@ABR
Hg19::chr18:28742652..28742696,-	p1@DSC1
Hg19::chr18:28742704..28742718,-	p3@DSC1
Hg19::chr18:28742813..28742824,-	p2@DSC1
Hg19::chr19:24006861..24006869,-	p@chr19:24006861..24006869 -
Hg19::chr19:35981358..35981374,-	p1@KRTDAP
Hg19::chr19:36004543..36004557,-	p3@DMKN
Hg19::chr19:39575002..39575011,+	p2@PAPL
Hg19::chr19:6333599..6333612,-	p1@ACER1
Hg19::chr19:6333614..6333628,-	p2@ACER1
Hg19::chr1:152769195..152769200,+	p1@LCE1D
Hg19::chr1:152779121..152779133,-	p1@LCE1C
Hg19::chr1:152783824..152783828,+	p@chr1:152783824..152783828 +
Hg19::chr1:152798501..152798507,+	p1@LCE1A
Hg19::chr1:152919679..152919684,+	p@chr1:152919679..152919684 +
Hg19::chr1:82165350..82165387,+	p7@LPHN2
Hg19::chr20:42647752..42647774,-	p@chr20:42647752..42647774 -
Hg19::chr20:43753104..43753107,-	p1@WFDC12
Hg19::chr21:45943378..45943388,+	p@chr21:45943378..45943388 +
Hg19::chr22:19466467..19466531,-	p4@UFD1L
Hg19::chr2:204400013..204400047,-	p1@RAPH1
Hg19::chr2:70188755..70188770,-	p2@ASPRV1
Hg19::chr3:106617542..106617578,+	p1@MTND5P16
Hg19::chr3:72387462..72387488,-	p@chr3:72387462..72387488 -
Hg19::chr5:147481380..147481398,+	p@chr5:147481380..147481398 +
Hg19::chr5:175837672..175837682,-	p@chr5:175837672..175837682 -
Hg19::chr5:67511303..67511333,+	p19@PIK3R1
Hg19::chr5:79948121..79948150,-	p@chr5:79948121..79948150 -
Hg19::chr5:99385325..99385350,-	p@chr5:99385325..99385350 -
Hg19::chr6:24955923..24955927,-	p@chr6:24955923..24955927 -
Hg19::chr6:25004678..25004688,-	p@chr6:25004678..25004688 -
Hg19::chr6:7578742..7578757,+	p@chr6:7578742..7578757 +
Hg19::chr7:7604061..7604072,-	p@chr7:7604061..7604072 -
Hg19::chr8:145118330..145118353,-	p@chr8:145118330..145118353 -
Hg19::chr8:145118355..145118372,-	p@chr8:145118355..145118372 -
Hg19::chr9:115209821..115209831,+	p@chr9:115209821..115209831 +
Hg19::chr9:87879610..87879618,+	p@chr9:87879610..87879618 +
Hg19::chr9:96698887..96698909,+	p@chr9:96698887..96698909 +
Hg19::chrX:114608236..114608237,+	p@chrX:114608236..114608237 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008544	epidermis development	7.04856330701466e-07
GO:0007398	ectoderm development	7.04856330701466e-07
GO:0009888	tissue development	1.85687015891158e-05
GO:0031424	keratinization	4.38422775379148e-05
GO:0009913	epidermal cell differentiation	7.63587513186168e-05
GO:0048730	epidermis morphogenesis	9.04537395326773e-05
GO:0048729	tissue morphogenesis	0.000175394644674861
GO:0048513	organ development	0.000260134436990178
GO:0048731	system development	0.00159417645728387
GO:0005882	intermediate filament	0.00386161842764485
GO:0045111	intermediate filament cytoskeleton	0.00386161842764485
GO:0048856	anatomical structure development	0.00409978112833119
GO:0007275	multicellular organismal development	0.00796701061421971
GO:0035030	phosphoinositide 3-kinase complex, class IA	0.008242081714353
GO:0001867	complement activation, lectin pathway	0.0144204585980542
GO:0043559	insulin binding	0.0144204585980542
GO:0009653	anatomical structure morphogenesis	0.017490948924798
GO:0043125	ErbB-3 class receptor binding	0.025625053188339
GO:0043560	insulin receptor substrate binding	0.0303387592429232
GO:0032502	developmental process	0.037338278254163
GO:0048009	insulin-like growth factor receptor signaling pathway	0.0383951793796147
GO:0005856	cytoskeleton	0.0383951793796147
GO:0042730	fibrinolysis	0.0383951793796147
GO:0017046	peptide hormone binding	0.0383951793796147
GO:0017089	glycolipid transporter activity	0.0383951793796147
GO:0051861	glycolipid binding	0.0383951793796147
GO:0035014	phosphoinositide 3-kinase regulator activity	0.0383951793796147
GO:0046836	glycolipid transport	0.0397103858141704
GO:0030280	structural constituent of epidermis	0.0397103858141704
GO:0005159	insulin-like growth factor receptor binding	0.042216059074444
GO:0030195	negative regulation of blood coagulation	0.0445584391949209
GO:0032501	multicellular organismal process	0.0453360829683806
GO:0030193	regulation of blood coagulation	0.0453360829683806

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
acinar cell of salivary gland	9.82e-67	3
acinar cell	1.95e-40	5
protein secreting cell	7.51e-34	6
glandular epithelial cell	7.49e-23	9
CD1a-positive Langerhans cell	2.32e-12	2
immature CD1a-positive Langerhans cell	2.32e-12	2
epithelial cell of alimentary canal	1.12e-10	20

Uber Anatomy

Ontology term	p-value	n
saliva-secreting gland	7.51e-34	6
gland of oral region	7.51e-34	6
gland of foregut	7.51e-34	6
oral gland	7.51e-34	6
oral cavity	7.51e-34	6
penis	1.67e-23	1
intromittent organ	1.67e-23	1
lateral plate mesenchyme	1.67e-23	1
undifferentiated genital tubercle	1.67e-23	1
somatopleure	1.67e-23	1
surface	2.10e-23	1
gland of gut	1.20e-20	10
oral opening	1.70e-16	22
uterine cervix	1.89e-15	6
neck of organ	1.89e-15	6
mouth	1.27e-12	29
stomodeum	1.27e-12	29
orifice	3.03e-10	36
tongue	1.30e-08	3
gustatory system	1.30e-08	3
future tongue	1.30e-08	3
subdivision of head	1.28e-07	49
exocrine gland	4.21e-07	31
exocrine system	4.21e-07	31
zone of skin	7.70e-07	4

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
MAFF#23764	7	4.98996829657742	0.000526070547454517	0.00455536704299829
MAFK#7975	8	2.74437803927391	0.00873294882301841	0.0331803129411823
ZNF263#10127	18	1.87333100590117	0.00595204974102803	0.0266929802002416

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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