Coexpression cluster:C1915

Full id: C1915_Mast_CD14_testicular_Eosinophils_Neutrophils_Basophils_Peripheral

Phase1 CAGE Peaks

Hg19::chr3:10291055..10291076,-	p2@BC009749
Hg19::chr6:15246200..15246214,+	p2@JARID2
Hg19::chr6:15246217..15246228,+	p3@JARID2
Hg19::chr6:15246261..15246312,+	p1@JARID2
Hg19::chr6:15246741..15246765,+	p9@JARID2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
hematopoietic stem cell	5.14e-48	168
angioblastic mesenchymal cell	5.14e-48	168
myeloid cell	1.46e-47	108
common myeloid progenitor	1.46e-47	108
hematopoietic oligopotent progenitor cell	2.26e-44	161
hematopoietic multipotent progenitor cell	2.26e-44	161
hematopoietic cell	3.85e-41	177
myeloid leukocyte	6.09e-37	72
leukocyte	4.31e-36	136
granulocyte monocyte progenitor cell	2.69e-33	67
myeloid lineage restricted progenitor cell	2.14e-32	66
hematopoietic lineage restricted progenitor cell	4.42e-30	120
macrophage dendritic cell progenitor	4.90e-30	61
monopoietic cell	8.44e-29	59
monocyte	8.44e-29	59
monoblast	8.44e-29	59
promonocyte	8.44e-29	59
defensive cell	1.20e-26	48
phagocyte	1.20e-26	48
nongranular leukocyte	1.50e-26	115
classical monocyte	1.33e-25	42
CD14-positive, CD16-negative classical monocyte	1.33e-25	42
stuff accumulating cell	6.08e-10	87
granulocyte	9.92e-07	8

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	7.13e-30	98
blood island	7.13e-30	98
bone marrow	7.74e-27	76
bone element	2.01e-26	82
hemolymphoid system	3.86e-26	108
immune system	2.58e-23	93
skeletal element	7.35e-23	90
skeletal system	4.20e-19	100

Disease

Ontology term	p-value	n
myeloid leukemia	1.80e-09	31
leukemia	1.72e-08	39

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
EBF1#1879	3	5.3438801079414	0.0118761556386811	0.0432428204423603
EGR1#1958	4	3.99054327584811	0.006780098300144	0.0287731282555359
ETS1#2113	3	5.8372565533214	0.00925327904563143	0.0349778569708169
FAM48A#55578	3	693.10125	6.35816014900193e-09	5.0267970310493e-07
GTF2B#2959	3	19.1662979605945	0.000292422965447241	0.00310274937400634
IRF3#3661	3	28.1891713268937	9.33088977565955e-05	0.00135649888262821
MXI1#4601	3	5.97694297725558	0.00865300488936688	0.0329556989876956
NFYA#4800	3	11.0553484198983	0.00147089290764443	0.00941348026113587
STAT1#6772	3	12.4239524983195	0.001046025344953	0.00739446602149356
TFAP2A#7020	3	9.91118062382697	0.00202154697751128	0.0117463193938077
TFAP2C#7022	3	6.48553716591613	0.00685895151794	0.0290640661168554
YY1#7528	4	3.92893659988308	0.00719386626991762	0.0298522011826099
ZNF143#7702	3	8.10052593133674	0.00362487051209098	0.0183357316516816

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.