Coexpression cluster:C176: Difference between revisions
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|id=C176 | |id=C176 | ||
|kegg_enrichment=hsa03040;Spliceosome;2.51E-06 | |kegg_enrichment=hsa03040;Spliceosome;2.51E-06 | ||
|ontology_enrichment_celltype=CL:0000738! | |ontology_enrichment_celltype=CL:0000738!1.10e-46!136;CL:0000037!1.21e-44!168;CL:0000566!1.21e-44!168;CL:0002032!4.62e-41!161;CL:0000837!4.62e-41!161;CL:0000988!1.04e-39!177;CL:0002031!8.21e-38!120;CL:0002087!6.28e-35!115;CL:0000766!1.51e-27!72;CL:0000763!2.44e-26!108;CL:0000049!2.44e-26!108;CL:0000557!3.95e-24!67;CL:0000839!3.74e-23!66;CL:0000860!9.83e-23!42;CL:0002057!9.83e-23!42;CL:0002009!6.17e-21!61;CL:0000473!5.78e-20!48;CL:0000234!5.78e-20!48;CL:0002194!6.62e-20!59;CL:0000576!6.62e-20!59;CL:0000040!6.62e-20!59;CL:0000559!6.62e-20!59;CL:0002242!8.64e-14!55;CL:0000838!2.85e-13!52;CL:0000542!3.59e-13!53;CL:0000051!3.59e-13!53;CL:0000791!6.39e-10!18;CL:0000789!6.39e-10!18;CL:0002420!6.39e-10!18;CL:0002419!6.39e-10!18;CL:0000790!6.39e-10!18;CL:0000084!1.02e-07!25;CL:0000827!1.02e-07!25;CL:0000625!7.98e-07!11 | ||
|ontology_enrichment_disease= | |ontology_enrichment_disease= | ||
|ontology_enrichment_uberon=UBERON:0002390! | |ontology_enrichment_uberon=UBERON:0002390!4.21e-27!98;UBERON:0003061!4.21e-27!98;UBERON:0007023!1.20e-24!114;UBERON:0002193!2.47e-23!108;UBERON:0002371!4.66e-19!76;UBERON:0001474!1.90e-18!82;UBERON:0002405!1.20e-17!93;UBERON:0004765!1.63e-14!90;UBERON:0001434!2.52e-12!100;UBERON:0001049!7.68e-10!56;UBERON:0005068!7.68e-10!56;UBERON:0006241!7.68e-10!56;UBERON:0007135!7.68e-10!56;UBERON:0000073!2.83e-09!53;UBERON:0002616!2.83e-09!53;UBERON:0002780!4.17e-09!41;UBERON:0001890!4.17e-09!41;UBERON:0003080!4.17e-09!41;UBERON:0006240!4.17e-09!41;UBERON:0001017!1.86e-07!81;UBERON:0001016!2.43e-07!89;UBERON:0000178!3.94e-07!15;UBERON:0000179!3.94e-07!15;UBERON:0000463!3.94e-07!15;UBERON:0001893!4.05e-07!34;UBERON:0003528!4.11e-07!34;UBERON:0002020!4.11e-07!34;UBERON:0000955!5.05e-07!68;UBERON:0006238!5.05e-07!68 | ||
|pathway_enrichment=0.000446803618670653;0.0404038129455033;4;128;Cell cycle (KEGG):04110!8.6270664663411e-07;0.000546093307319392;6;116;Androgen Receptor Signaling Pathway (Wikipathways):WP138!8.88697950567494e-05;0.0140636450677306;5;162;TNF alpha/NF-kB down reg. targets (Netpath):NetPath_9!4.490266583751e-05;0.00947446249171461;3;25;{BCLAF1,25} (Static Module):NA!1.51977732997624e-05;0.00481009524937481;5;112;{EP300,115} (Static Module):NA!0.000234032280849933;0.0296284867556015;4;108;{HDAC1,108} (Static Module):NA!0.000335435775220664;0.03538847428578;2;10;{TIA1,10} (Static Module):NA | |pathway_enrichment=0.000446803618670653;0.0404038129455033;4;128;Cell cycle (KEGG):04110!8.6270664663411e-07;0.000546093307319392;6;116;Androgen Receptor Signaling Pathway (Wikipathways):WP138!8.88697950567494e-05;0.0140636450677306;5;162;TNF alpha/NF-kB down reg. targets (Netpath):NetPath_9!4.490266583751e-05;0.00947446249171461;3;25;{BCLAF1,25} (Static Module):NA!1.51977732997624e-05;0.00481009524937481;5;112;{EP300,115} (Static Module):NA!0.000234032280849933;0.0296284867556015;4;108;{HDAC1,108} (Static Module):NA!0.000335435775220664;0.03538847428578;2;10;{TIA1,10} (Static Module):NA | ||
|tf_chipseq_enrich=ATF3#467;28:6.41804986457393:1.6703669379992e-15:3.08763632987077e-13!BCL3#602;10:3.52521457181003:0.000565467227653071:0.00482332830683266!BCLAF1#9774;25:5.52363459441884:1.98946434955337e-12:2.71250218280685e-10!BHLHE40#8553;14:6.41025907813963:4.12477158197312e-08:2.71961502051572e-06!BRCA1#672;42:8.65038456138161:8.41940743150004e-29:3.18592207513925e-26!CCNT2#905;71:4.5905133873913:1.17047810954241e-35:5.84897431973681e-33!CEBPB#1051;41:3.33486788427365:4.42490965794855e-13:6.49063398548439e-11!CHD2#1106;60:6.33307520456134:5.92161677601478e-36:2.98767021483192e-33!CTCF#10664;37:2.02377026330384:7.43593228313639e-06:0.000212942509382638!CTCFL#140690;21:4.23138736263736:1.7517413286226e-08:1.26521516334727e-06!E2F1#1869;72:3.60542881093175:1.9471004105034e-29:7.58780670793152e-27!E2F4#1874;43:5.55843462813501:5.47244369254552e-22:1.5240974581487e-19!E2F6#1876;72:3.68607359879808:4.55928480911686e-30:1.83141210068983e-27!EBF1#1879;22:1.99941092473998:0.00111439344640342:0.00765496824183942!EGR1#1958;68:3.46118549435805:6.51761727185527e-26:2.14729788724067e-23!ELF1#1997;90:3.91049812543549:4.17145374789434e-47:2.79270806395088e-44!ELK4#2005;37:6.1297981771767:4.87193863613021e-20:1.2410253639483e-17!EP300#2033;36:2.48838675657179:6.86346032735989e-08:4.16509548593341e-06!ETS1#2113;53:5.26147274364004:6.29766179707759e-27:2.17788576299664e-24!FAM48A#55578;2:23.5748724489796:0.00335169998841279:0.017288891939045!FOS#2353;30:2.75447611496768:1.53138272428548e-07:8.59871399686295e-06!FOSL1#8061;7:2.83668426545522:0.0121108099384669:0.0439196110685628!FOSL2#2355;25:4.31892872565349:3.65094048626798e-10:3.63836425043265e-08!FOXA1#3169;26:2.939968504939:3.90609694567911e-07:1.89743655306874e-05!GABPB1#2553;65:4.68774948318205:5.52345738383487e-32:2.40360152379304e-29!GATA1#2623;31:4.28948522916136:1.72589674405777e-12:2.36860617677595e-10!GATA3#2625;19:5.28054908966239:2.81172131235106e-09:2.36626399791001e-07!GTF2B#2959;13:4.2374468280226:1.22632919077175e-05:0.000305089553013364!GTF2F1#2962;38:4.93986850323256:1.80130492470792e-17:3.80053505114283e-15!HDAC2#3066;20:2.73788168094413:3.20280711595823e-05:0.000642770892358882!HDAC8#55869;2:15.8486537472132:0.00723490186487388:0.0299427745538167!HEY1#23462;90:3.71030605999504:4.1609239846454e-45:2.71601712520238e-42!HMGN3#9324;60:5.0072741163371:2.73654242372022e-30:1.1034816764128e-27!HNF4A#3172;17:4.01274424663482:1.01493047995734e-06:4.27930255939704e-05!HNF4G#3174;12:3.52082724813634:0.000157066064565252:0.00198042046566828!IRF1#3659;63:4.90960527014822:8.25138354938216e-32:3.54636315437829e-29!IRF3#3661;12:5.75289210752934:1.27180261288656e-06:5.08911084625516e-05!IRF4#3662;10:2.23617476395348:0.0141290041740246:0.0495773104062273!JUN#3725;26:3.31973019388515:3.57705126804954e-08:2.38559168188905e-06!JUNB#3726;12:3.74824073385565:8.77420472340428e-05:0.00129522143760794!JUND#3727;47:3.35458372722386:2.10680643089929e-15:3.83332328983782e-13!MAX#4149;52:3.42380496396296:8.31352282543196e-18:1.80510605065549e-15!MEF2A#4205;17:3.25137679044846:1.63684044987878e-05:0.000378124263978965!MEF2C#4208;10:4.21544433598205:0.000138129092722616:0.00180461149798064!MXI1#4601;36:3.6593528432177:1.57729933432822e-12:2.17323964614651e-10!MYC#4609;63:3.35718120317747:1.78622064781502e-22:5.08313619174802e-20!NANOG#79923;13:3.87940939033841:3.06903784187106e-05:0.000626029771810882!NFE2#4778;8:6.30238862462278:4.39169911094187e-05:0.000778717594987534!NFKB1#4790;78:4.36805048048081:1.28609391933949e-39:7.38012982647788e-37!NFYA#4800;21:3.94833872139226:5.6858364174278e-08:3.56009034532219e-06!NFYB#4801;22:3.76240256712043:6.01278299330073e-08:3.73568734703947e-06!NR2C2#7182;12:3.99362582513153:4.81291931224098e-05:0.000836784551441878!NR3C1#2908;24:3.66686285661381:2.13598876113865e-08:1.5154927325038e-06!NRF1#4899;35:4.36081408846818:2.24727625957165e-14:3.77944098668927e-12!PAX5#5079;60:4.08340746806806:1.74039086987352e-25:5.62738953742168e-23!PBX3#5090;14:3.13064466953488:0.000147459701684741:0.00190271111740211!POLR2A#5430;98:2.14745317655807:2.87511288600786e-33:1.31123980219116e-30!POU2F2#5452;56:5.20349946156716:1.40381579124456e-28:5.23618276506397e-26!RAD21#5885;18:1.90194500120626:0.00570551270883114:0.0257220945263582!RDBP#7936;7:10.9741717135732:4.0215919736412e-06:0.000129873544877895!REST#5978;47:4.62807499651038:5.18680252218766e-21:1.37488443810852e-18!RFX5#5993;47:5.7780796824303:4.67581579046352e-25:1.48883391872018e-22!RXRA#6256;17:3.48233154454353:6.73788686337537e-06:0.000196618654966208!SETDB1#9869;11:4.5257172240624:3.33593832103034e-05:0.000662613279402981!SIN3A#25942;74:4.08425989575837:1.94975475531037e-34:9.29819346529042e-32!SIX5#147912;35:6.10239834123536:7.9758994485173e-19:1.87189879214314e-16!SMARCB1#6598;25:4.65630504621363:7.61792959830484e-11:8.36602470365257e-09!SP1#6667;58:3.37251142787931:3.62829933446048e-20:9.3104657049562e-18!SP2#6668;21:5.60432796296671:1.22359805870121e-10:1.31337469324455e-08!SPI1#6688;37:3.09755071240144:9.29923923855307e-11:1.01272497063112e-08!SREBF1#6720;13:6.23546982373824:1.79067098469578e-07:9.80681106295978e-06!SRF#6722;38:5.34992626492221:1.26503668495048e-18:2.90371794152843e-16!STAT1#6772;17:3.5919590556366:4.48381955876548e-06:0.000140247268912222!STAT2#6773;7:4.66169794188862:0.000809835252259833:0.00618082314460426!STAT3#6774;26:2.79087846863276:1.05329098027572e-06:4.39140346063937e-05!TAF1#6872;94:3.20659541693936:4.52450544989909e-44:2.88130990659763e-41!TAF7#6879;58:6.76651046413864:5.26953738907919e-36:2.67157871542738e-33!TBP#6908;92:3.47982554298844:6.92551135599247e-45:4.46477457104011e-42!TCF12#6938;31:3.36396338742632:7.84046337193137e-10:7.41040863439946e-08!TCF7L2#6934;33:3.62669210799523:2.45988660044192e-11:2.90949146844342e-09!TFAP2A#7020;20:3.37114987204999:1.48572570856753e-06:5.73209114433264e-05!TFAP2C#7022;35:3.8604387892358:7.93136945585133e-13:1.13316592968489e-10!THAP1#55145;15:4.8013996841099:5.26632433244004e-07:2.45869310217124e-05!TRIM28#10155;21:3.98368393827054:4.89181192718202e-08:3.15367867816644e-06!USF1#7391;46:2.9860098648119:3.91121687526651e-13:5.76140450262283e-11!USF2#7392;30:3.97720328114375:2.87850176152008e-11:3.35897034046253e-09!WRNIP1#56897;4:4.48244752446433:0.0125932712562831:0.0455380048727565!YY1#7528;83:4.15946094120276:2.52330133653372e-42:1.51454636946118e-39!ZBTB33#10009;25:8.07773597703601:4.22079339190957e-16:8.20885365098032e-14!ZBTB7A#51341;51:3.8259936194048:1.78898290656159e-19:4.31500198102509e-17!ZEB1#6935;18:3.10195690118153:1.67325741842288e-05:0.000385683803846099!ZNF143#7702;35:4.82174162579568:1.11394479873663e-15:2.08867649614462e-13!ZNF263#10127;40:3.35585372939211:8.15364124798729e-13:1.16016095136041e-10 | 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| ||
}} | }} |
Revision as of 11:40, 19 October 2012
Full id: C176_Eosinophils_Neutrophils_Mast_CD14_CD4_Basophils_CD19
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
p.value | FDR | nGenes | nPathway | Name |
---|---|---|---|---|
0.000446803618670653 | 0.0404038129455033 | 4 | 128 | Cell cycle (KEGG):04110 |
8.6270664663411e-07 | 0.000546093307319392 | 6 | 116 | Androgen Receptor Signaling Pathway (Wikipathways):WP138 |
8.88697950567494e-05 | 0.0140636450677306 | 5 | 162 | TNF alpha/NF-kB down reg. targets (Netpath):NetPath_9 |
4.490266583751e-05 | 0.00947446249171461 | 3 | 25 | {BCLAF1,25} (Static Module):NA |
1.51977732997624e-05 | 0.00481009524937481 | 5 | 112 | {EP300,115} (Static Module):NA |
0.000234032280849933 | 0.0296284867556015 | 4 | 108 | {HDAC1,108} (Static Module):NA |
0.000335435775220664 | 0.03538847428578 | 2 | 10 | {TIA1,10} (Static Module):NA |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0016070 | RNA metabolic process | 2.04805303337828e-16 |
GO:0005634 | nucleus | 5.91057991685637e-16 |
GO:0005654 | nucleoplasm | 7.36093040758252e-12 |
GO:0044428 | nuclear part | 1.65553376857781e-11 |
GO:0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 1.9791392473282e-11 |
GO:0043283 | biopolymer metabolic process | 7.54138067960235e-11 |
GO:0006355 | regulation of transcription, DNA-dependent | 7.93606534422575e-11 |
GO:0031981 | nuclear lumen | 1.4487896449597e-10 |
GO:0044451 | nucleoplasm part | 1.4487896449597e-10 |
GO:0006351 | transcription, DNA-dependent | 1.4487896449597e-10 |
GO:0032774 | RNA biosynthetic process | 1.4487896449597e-10 |
GO:0043233 | organelle lumen | 1.07378294608341e-09 |
GO:0031974 | membrane-enclosed lumen | 1.07378294608341e-09 |
GO:0045449 | regulation of transcription | 1.20411774222063e-09 |
GO:0019219 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 2.07478549350105e-09 |
GO:0010467 | gene expression | 3.23347342085246e-09 |
GO:0043231 | intracellular membrane-bound organelle | 3.89486616805506e-09 |
GO:0043227 | membrane-bound organelle | 3.89486616805506e-09 |
GO:0006350 | transcription | 4.01781254181114e-09 |
GO:0010468 | regulation of gene expression | 5.09781748222147e-09 |
GO:0016607 | nuclear speck | 5.39835757687086e-09 |
GO:0044424 | intracellular part | 5.58612787508296e-09 |
GO:0031323 | regulation of cellular metabolic process | 1.12509981391023e-08 |
GO:0003677 | DNA binding | 2.93357379289555e-08 |
GO:0016604 | nuclear body | 2.93357379289555e-08 |
GO:0019222 | regulation of metabolic process | 6.3952309874976e-08 |
GO:0003676 | nucleic acid binding | 1.00348876840398e-07 |
GO:0050794 | regulation of cellular process | 5.85585363872622e-07 |
GO:0005622 | intracellular | 5.98883247284247e-07 |
GO:0043229 | intracellular organelle | 1.61683472984701e-06 |
GO:0043226 | organelle | 1.61683472984701e-06 |
GO:0044446 | intracellular organelle part | 3.17560673516358e-06 |
GO:0044422 | organelle part | 3.29559932897327e-06 |
GO:0016071 | mRNA metabolic process | 3.98629041141266e-06 |
GO:0050789 | regulation of biological process | 4.84705507682382e-06 |
GO:0065007 | biological regulation | 1.44141419662829e-05 |
GO:0043170 | macromolecule metabolic process | 1.88498361909312e-05 |
GO:0006325 | establishment and/or maintenance of chromatin architecture | 2.78098088741691e-05 |
GO:0006323 | DNA packaging | 2.98809127512521e-05 |
GO:0006259 | DNA metabolic process | 4.37513673725924e-05 |
GO:0016568 | chromatin modification | 4.47292275502309e-05 |
GO:0008380 | RNA splicing | 5.09901043828198e-05 |
GO:0051276 | chromosome organization and biogenesis | 8.84265175142438e-05 |
GO:0018076 | N-terminal peptidyl-lysine acetylation | 0.000109206058845818 |
GO:0018394 | peptidyl-lysine acetylation | 0.000109206058845818 |
GO:0008270 | zinc ion binding | 0.000122435686528734 |
GO:0006397 | mRNA processing | 0.000136985932640894 |
GO:0045941 | positive regulation of transcription | 0.000151644506336996 |
GO:0045935 | positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.000181131400730647 |
GO:0003724 | RNA helicase activity | 0.0002380279519532 |
GO:0044237 | cellular metabolic process | 0.000260749868446827 |
GO:0006366 | transcription from RNA polymerase II promoter | 0.000260749868446827 |
GO:0044238 | primary metabolic process | 0.000322919765554256 |
GO:0006396 | RNA processing | 0.000546972447298479 |
GO:0045893 | positive regulation of transcription, DNA-dependent | 0.000577921422521647 |
GO:0031325 | positive regulation of cellular metabolic process | 0.000580837189861837 |
GO:0006474 | N-terminal protein amino acid acetylation | 0.0006005290158013 |
GO:0009893 | positive regulation of metabolic process | 0.000817596507976426 |
GO:0018205 | peptidyl-lysine modification | 0.000992124687775453 |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 0.00113536569907426 |
GO:0017053 | transcriptional repressor complex | 0.0011980133531595 |
GO:0016481 | negative regulation of transcription | 0.00177456209167396 |
GO:0000123 | histone acetyltransferase complex | 0.00197189449901821 |
GO:0016573 | histone acetylation | 0.00197189449901821 |
GO:0018409 | peptide or protein amino-terminal blocking | 0.00226235410115885 |
GO:0046914 | transition metal ion binding | 0.00239710015130057 |
GO:0045934 | negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.00250271221666721 |
GO:0003723 | RNA binding | 0.00356557517576573 |
GO:0031365 | N-terminal protein amino acid modification | 0.00356557517576573 |
GO:0005515 | protein binding | 0.00362308024683212 |
GO:0006473 | protein amino acid acetylation | 0.00467267787776979 |
GO:0000184 | mRNA catabolic process, nonsense-mediated decay | 0.00467267787776979 |
GO:0016564 | transcription repressor activity | 0.00478296814858988 |
GO:0031324 | negative regulation of cellular metabolic process | 0.00505553640616498 |
GO:0004468 | lysine N-acetyltransferase activity | 0.00629279275980798 |
GO:0004402 | histone acetyltransferase activity | 0.00629279275980798 |
GO:0045814 | negative regulation of gene expression, epigenetic | 0.00672036348106831 |
GO:0006887 | exocytosis | 0.00746455895371333 |
GO:0006357 | regulation of transcription from RNA polymerase II promoter | 0.00753245338880945 |
GO:0006402 | mRNA catabolic process | 0.00805062666196582 |
GO:0009892 | negative regulation of metabolic process | 0.00839215155288564 |
GO:0003682 | chromatin binding | 0.00846323818811058 |
GO:0043543 | protein amino acid acylation | 0.00886539050646993 |
GO:0018193 | peptidyl-amino acid modification | 0.00887745789516632 |
GO:0043425 | bHLH transcription factor binding | 0.00978168405706219 |
GO:0051577 | MyoD binding | 0.00978168405706219 |
GO:0043426 | MRF binding | 0.00978168405706219 |
GO:0004883 | glucocorticoid receptor activity | 0.00978168405706219 |
GO:0031932 | TORC 2 complex | 0.00978168405706219 |
GO:0004386 | helicase activity | 0.0100200006009732 |
GO:0044464 | cell part | 0.0104811135956777 |
GO:0006950 | response to stress | 0.0111099691207288 |
GO:0048522 | positive regulation of cellular process | 0.0111447540751904 |
GO:0016043 | cellular component organization and biogenesis | 0.0114322406403173 |
GO:0006996 | organelle organization and biogenesis | 0.011529206903564 |
GO:0003712 | transcription cofactor activity | 0.0128320861573194 |
GO:0016563 | transcription activator activity | 0.0137873544696713 |
GO:0031965 | nuclear membrane | 0.0142219074408801 |
GO:0030323 | respiratory tube development | 0.0142219074408801 |
GO:0043687 | post-translational protein modification | 0.014700746057638 |
GO:0006401 | RNA catabolic process | 0.0159192083747378 |
GO:0006464 | protein modification process | 0.0164906416690819 |
GO:0042975 | peroxisome proliferator activated receptor binding | 0.0164906416690819 |
GO:0051896 | regulation of protein kinase B signaling cascade | 0.0164906416690819 |
GO:0016570 | histone modification | 0.0164906416690819 |
GO:0001666 | response to hypoxia | 0.0164906416690819 |
GO:0006512 | ubiquitin cycle | 0.0171365002087408 |
GO:0048518 | positive regulation of biological process | 0.0173445567288284 |
GO:0016569 | covalent chromatin modification | 0.0173730484453595 |
GO:0009952 | anterior/posterior pattern formation | 0.0207410997161865 |
GO:0008026 | ATP-dependent helicase activity | 0.0217252221298926 |
GO:0007049 | cell cycle | 0.0217252221298926 |
GO:0003713 | transcription coactivator activity | 0.022472748674848 |
GO:0007243 | protein kinase cascade | 0.0233284123103522 |
GO:0043412 | biopolymer modification | 0.0233284123103522 |
GO:0005635 | nuclear envelope | 0.0240200551782881 |
GO:0006281 | DNA repair | 0.0262042156577 |
GO:0040029 | regulation of gene expression, epigenetic | 0.0265266456191394 |
GO:0045892 | negative regulation of transcription, DNA-dependent | 0.0265266456191394 |
GO:0007519 | skeletal muscle development | 0.0276633383013126 |
GO:0003700 | transcription factor activity | 0.0283948889122752 |
GO:0005667 | transcription factor complex | 0.0283948889122752 |
GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 0.0289101437357237 |
GO:0000398 | nuclear mRNA splicing, via spliceosome | 0.0289101437357237 |
GO:0000375 | RNA splicing, via transesterification reactions | 0.0289101437357237 |
GO:0008080 | N-acetyltransferase activity | 0.0310977097245966 |
GO:0008134 | transcription factor binding | 0.0331028901367043 |
GO:0043491 | protein kinase B signaling cascade | 0.0331028901367043 |
GO:0017016 | Ras GTPase binding | 0.0331496531642673 |
GO:0006974 | response to DNA damage stimulus | 0.0367141147123424 |
GO:0045045 | secretory pathway | 0.0374313327026615 |
GO:0043285 | biopolymer catabolic process | 0.0378322604307343 |
GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex | 0.0382270460094718 |
GO:0031267 | small GTPase binding | 0.038589881052216 |
GO:0003002 | regionalization | 0.0392664956444353 |
GO:0016407 | acetyltransferase activity | 0.0392664956444353 |
GO:0008415 | acyltransferase activity | 0.0392664956444353 |
GO:0014706 | striated muscle development | 0.0395550349984727 |
GO:0016747 | transferase activity, transferring groups other than amino-acyl groups | 0.0395550349984727 |
GO:0016410 | N-acyltransferase activity | 0.0400757210967511 |
GO:0006359 | regulation of transcription from RNA polymerase III promoter | 0.0417907099392139 |
GO:0051020 | GTPase binding | 0.0465388385645271 |
GO:0031532 | actin cytoskeleton reorganization | 0.0467486869842573 |
GO:0017022 | myosin binding | 0.0467486869842573 |
GO:0006333 | chromatin assembly or disassembly | 0.0474676277540671 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
hematopoietic system | 4.21e-27 | 98 |
blood island | 4.21e-27 | 98 |
adult organism | 1.20e-24 | 114 |
hemolymphoid system | 2.47e-23 | 108 |
bone marrow | 4.66e-19 | 76 |
bone element | 1.90e-18 | 82 |
immune system | 1.20e-17 | 93 |
skeletal element | 1.63e-14 | 90 |
skeletal system | 2.52e-12 | 100 |
neural tube | 7.68e-10 | 56 |
neural rod | 7.68e-10 | 56 |
future spinal cord | 7.68e-10 | 56 |
neural keel | 7.68e-10 | 56 |
regional part of nervous system | 2.83e-09 | 53 |
regional part of brain | 2.83e-09 | 53 |
regional part of forebrain | 4.17e-09 | 41 |
forebrain | 4.17e-09 | 41 |
anterior neural tube | 4.17e-09 | 41 |
future forebrain | 4.17e-09 | 41 |
central nervous system | 1.86e-07 | 81 |
nervous system | 2.43e-07 | 89 |
blood | 3.94e-07 | 15 |
haemolymphatic fluid | 3.94e-07 | 15 |
organism substance | 3.94e-07 | 15 |
telencephalon | 4.05e-07 | 34 |
brain grey matter | 4.11e-07 | 34 |
gray matter | 4.11e-07 | 34 |
brain | 5.05e-07 | 68 |
future brain | 5.05e-07 | 68 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
{{{tfbs_overrepresentation_jaspar}}} |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
TF | #promoters | Enrichment | p-value | q-value |
---|---|---|---|---|
ATF3#467 | 28 | 6.41804986457393 | 1.6703669379992e-15 | 3.08763632987077e-13 |
BCL3#602 | 10 | 3.52521457181003 | 0.000565467227653071 | 0.00482332830683266 |
BCLAF1#9774 | 25 | 5.52363459441884 | 1.98946434955337e-12 | 2.71250218280685e-10 |
BHLHE40#8553 | 14 | 6.41025907813963 | 4.12477158197312e-08 | 2.71961502051572e-06 |
BRCA1#672 | 42 | 8.65038456138161 | 8.41940743150004e-29 | 3.18592207513925e-26 |
CCNT2#905 | 71 | 4.5905133873913 | 1.17047810954241e-35 | 5.84897431973681e-33 |
CEBPB#1051 | 41 | 3.33486788427365 | 4.42490965794855e-13 | 6.49063398548439e-11 |
CHD2#1106 | 60 | 6.33307520456134 | 5.92161677601478e-36 | 2.98767021483192e-33 |
CTCF#10664 | 37 | 2.02377026330384 | 7.43593228313639e-06 | 0.000212942509382638 |
CTCFL#140690 | 21 | 4.23138736263736 | 1.7517413286226e-08 | 1.26521516334727e-06 |
E2F1#1869 | 72 | 3.60542881093175 | 1.9471004105034e-29 | 7.58780670793152e-27 |
E2F4#1874 | 43 | 5.55843462813501 | 5.47244369254552e-22 | 1.5240974581487e-19 |
E2F6#1876 | 72 | 3.68607359879808 | 4.55928480911686e-30 | 1.83141210068983e-27 |
EBF1#1879 | 22 | 1.99941092473998 | 0.00111439344640342 | 0.00765496824183942 |
EGR1#1958 | 68 | 3.46118549435805 | 6.51761727185527e-26 | 2.14729788724067e-23 |
ELF1#1997 | 90 | 3.91049812543549 | 4.17145374789434e-47 | 2.79270806395088e-44 |
ELK4#2005 | 37 | 6.1297981771767 | 4.87193863613021e-20 | 1.2410253639483e-17 |
EP300#2033 | 36 | 2.48838675657179 | 6.86346032735989e-08 | 4.16509548593341e-06 |
ETS1#2113 | 53 | 5.26147274364004 | 6.29766179707759e-27 | 2.17788576299664e-24 |
FAM48A#55578 | 2 | 23.5748724489796 | 0.00335169998841279 | 0.017288891939045 |
FOS#2353 | 30 | 2.75447611496768 | 1.53138272428548e-07 | 8.59871399686295e-06 |
FOSL1#8061 | 7 | 2.83668426545522 | 0.0121108099384669 | 0.0439196110685628 |
FOSL2#2355 | 25 | 4.31892872565349 | 3.65094048626798e-10 | 3.63836425043265e-08 |
FOXA1#3169 | 26 | 2.939968504939 | 3.90609694567911e-07 | 1.89743655306874e-05 |
GABPB1#2553 | 65 | 4.68774948318205 | 5.52345738383487e-32 | 2.40360152379304e-29 |
GATA1#2623 | 31 | 4.28948522916136 | 1.72589674405777e-12 | 2.36860617677595e-10 |
GATA3#2625 | 19 | 5.28054908966239 | 2.81172131235106e-09 | 2.36626399791001e-07 |
GTF2B#2959 | 13 | 4.2374468280226 | 1.22632919077175e-05 | 0.000305089553013364 |
GTF2F1#2962 | 38 | 4.93986850323256 | 1.80130492470792e-17 | 3.80053505114283e-15 |
HDAC2#3066 | 20 | 2.73788168094413 | 3.20280711595823e-05 | 0.000642770892358882 |
HDAC8#55869 | 2 | 15.8486537472132 | 0.00723490186487388 | 0.0299427745538167 |
HEY1#23462 | 90 | 3.71030605999504 | 4.1609239846454e-45 | 2.71601712520238e-42 |
HMGN3#9324 | 60 | 5.0072741163371 | 2.73654242372022e-30 | 1.1034816764128e-27 |
HNF4A#3172 | 17 | 4.01274424663482 | 1.01493047995734e-06 | 4.27930255939704e-05 |
HNF4G#3174 | 12 | 3.52082724813634 | 0.000157066064565252 | 0.00198042046566828 |
IRF1#3659 | 63 | 4.90960527014822 | 8.25138354938216e-32 | 3.54636315437829e-29 |
IRF3#3661 | 12 | 5.75289210752934 | 1.27180261288656e-06 | 5.08911084625516e-05 |
IRF4#3662 | 10 | 2.23617476395348 | 0.0141290041740246 | 0.0495773104062273 |
JUN#3725 | 26 | 3.31973019388515 | 3.57705126804954e-08 | 2.38559168188905e-06 |
JUNB#3726 | 12 | 3.74824073385565 | 8.77420472340428e-05 | 0.00129522143760794 |
JUND#3727 | 47 | 3.35458372722386 | 2.10680643089929e-15 | 3.83332328983782e-13 |
MAX#4149 | 52 | 3.42380496396296 | 8.31352282543196e-18 | 1.80510605065549e-15 |
MEF2A#4205 | 17 | 3.25137679044846 | 1.63684044987878e-05 | 0.000378124263978965 |
MEF2C#4208 | 10 | 4.21544433598205 | 0.000138129092722616 | 0.00180461149798064 |
MXI1#4601 | 36 | 3.6593528432177 | 1.57729933432822e-12 | 2.17323964614651e-10 |
MYC#4609 | 63 | 3.35718120317747 | 1.78622064781502e-22 | 5.08313619174802e-20 |
NANOG#79923 | 13 | 3.87940939033841 | 3.06903784187106e-05 | 0.000626029771810882 |
NFE2#4778 | 8 | 6.30238862462278 | 4.39169911094187e-05 | 0.000778717594987534 |
NFKB1#4790 | 78 | 4.36805048048081 | 1.28609391933949e-39 | 7.38012982647788e-37 |
NFYA#4800 | 21 | 3.94833872139226 | 5.6858364174278e-08 | 3.56009034532219e-06 |
NFYB#4801 | 22 | 3.76240256712043 | 6.01278299330073e-08 | 3.73568734703947e-06 |
NR2C2#7182 | 12 | 3.99362582513153 | 4.81291931224098e-05 | 0.000836784551441878 |
NR3C1#2908 | 24 | 3.66686285661381 | 2.13598876113865e-08 | 1.5154927325038e-06 |
NRF1#4899 | 35 | 4.36081408846818 | 2.24727625957165e-14 | 3.77944098668927e-12 |
PAX5#5079 | 60 | 4.08340746806806 | 1.74039086987352e-25 | 5.62738953742168e-23 |
PBX3#5090 | 14 | 3.13064466953488 | 0.000147459701684741 | 0.00190271111740211 |
POLR2A#5430 | 98 | 2.14745317655807 | 2.87511288600786e-33 | 1.31123980219116e-30 |
POU2F2#5452 | 56 | 5.20349946156716 | 1.40381579124456e-28 | 5.23618276506397e-26 |
RAD21#5885 | 18 | 1.90194500120626 | 0.00570551270883114 | 0.0257220945263582 |
RDBP#7936 | 7 | 10.9741717135732 | 4.0215919736412e-06 | 0.000129873544877895 |
REST#5978 | 47 | 4.62807499651038 | 5.18680252218766e-21 | 1.37488443810852e-18 |
RFX5#5993 | 47 | 5.7780796824303 | 4.67581579046352e-25 | 1.48883391872018e-22 |
RXRA#6256 | 17 | 3.48233154454353 | 6.73788686337537e-06 | 0.000196618654966208 |
SETDB1#9869 | 11 | 4.5257172240624 | 3.33593832103034e-05 | 0.000662613279402981 |
SIN3A#25942 | 74 | 4.08425989575837 | 1.94975475531037e-34 | 9.29819346529042e-32 |
SIX5#147912 | 35 | 6.10239834123536 | 7.9758994485173e-19 | 1.87189879214314e-16 |
SMARCB1#6598 | 25 | 4.65630504621363 | 7.61792959830484e-11 | 8.36602470365257e-09 |
SP1#6667 | 58 | 3.37251142787931 | 3.62829933446048e-20 | 9.3104657049562e-18 |
SP2#6668 | 21 | 5.60432796296671 | 1.22359805870121e-10 | 1.31337469324455e-08 |
SPI1#6688 | 37 | 3.09755071240144 | 9.29923923855307e-11 | 1.01272497063112e-08 |
SREBF1#6720 | 13 | 6.23546982373824 | 1.79067098469578e-07 | 9.80681106295978e-06 |
SRF#6722 | 38 | 5.34992626492221 | 1.26503668495048e-18 | 2.90371794152843e-16 |
STAT1#6772 | 17 | 3.5919590556366 | 4.48381955876548e-06 | 0.000140247268912222 |
STAT2#6773 | 7 | 4.66169794188862 | 0.000809835252259833 | 0.00618082314460426 |
STAT3#6774 | 26 | 2.79087846863276 | 1.05329098027572e-06 | 4.39140346063937e-05 |
TAF1#6872 | 94 | 3.20659541693936 | 4.52450544989909e-44 | 2.88130990659763e-41 |
TAF7#6879 | 58 | 6.76651046413864 | 5.26953738907919e-36 | 2.67157871542738e-33 |
TBP#6908 | 92 | 3.47982554298844 | 6.92551135599247e-45 | 4.46477457104011e-42 |
TCF12#6938 | 31 | 3.36396338742632 | 7.84046337193137e-10 | 7.41040863439946e-08 |
TCF7L2#6934 | 33 | 3.62669210799523 | 2.45988660044192e-11 | 2.90949146844342e-09 |
TFAP2A#7020 | 20 | 3.37114987204999 | 1.48572570856753e-06 | 5.73209114433264e-05 |
TFAP2C#7022 | 35 | 3.8604387892358 | 7.93136945585133e-13 | 1.13316592968489e-10 |
THAP1#55145 | 15 | 4.8013996841099 | 5.26632433244004e-07 | 2.45869310217124e-05 |
TRIM28#10155 | 21 | 3.98368393827054 | 4.89181192718202e-08 | 3.15367867816644e-06 |
USF1#7391 | 46 | 2.9860098648119 | 3.91121687526651e-13 | 5.76140450262283e-11 |
USF2#7392 | 30 | 3.97720328114375 | 2.87850176152008e-11 | 3.35897034046253e-09 |
WRNIP1#56897 | 4 | 4.48244752446433 | 0.0125932712562831 | 0.0455380048727565 |
YY1#7528 | 83 | 4.15946094120276 | 2.52330133653372e-42 | 1.51454636946118e-39 |
ZBTB33#10009 | 25 | 8.07773597703601 | 4.22079339190957e-16 | 8.20885365098032e-14 |
ZBTB7A#51341 | 51 | 3.8259936194048 | 1.78898290656159e-19 | 4.31500198102509e-17 |
ZEB1#6935 | 18 | 3.10195690118153 | 1.67325741842288e-05 | 0.000385683803846099 |
ZNF143#7702 | 35 | 4.82174162579568 | 1.11394479873663e-15 | 2.08867649614462e-13 |
ZNF263#10127 | 40 | 3.35585372939211 | 8.15364124798729e-13 | 1.16016095136041e-10 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data