MCL coexpression mm9:1685

Phase1 CAGE Peaks

	Short description
Mm9::chr15:81756578..81756653,-	p1@Polr3h
Mm9::chr19:4615453..4615512,-	p1@Lrfn4
Mm9::chr3:34549096..34549111,+	p3@Sox2
Mm9::chr8:87238155..87238187,-	p13@Nfix
Mm9::chr9:108998049..108998061,+	p5@Plxnb1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0006101	citrate metabolic process	0.0405323965856262
GO:0050973	detection of mechanical stimulus during equilibrioception	0.0405323965856262
GO:0050957	equilibrioception	0.0405323965856262

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
ectodermal cell	2.67e-27	44
neurectodermal cell	2.67e-27	44
neural cell	1.04e-26	43
non-terminally differentiated cell	5.78e-23	49
neuron	1.86e-19	33
neuronal stem cell	1.86e-19	33
neuroblast	1.86e-19	33
electrically signaling cell	1.86e-19	33
electrically responsive cell	5.27e-16	39
electrically active cell	5.27e-16	39
CNS neuron (sensu Vertebrata)	2.74e-15	23
neuroblast (sensu Vertebrata)	2.74e-15	23
embryonic cell	1.23e-12	70
migratory neural crest cell	5.23e-08	10
neuron associated cell	5.23e-08	10
glial cell (sensu Vertebrata)	5.23e-08	10
neuron associated cell (sensu Vertebrata)	5.23e-08	10
glial cell	5.23e-08	10
glioblast	5.23e-08	10
glioblast (sensu Vertebrata)	5.23e-08	10
oligodendrocyte precursor cell	8.07e-07	8

Uber Anatomy

Ontology term	p-value	n
nervous system	6.11e-40	75
central nervous system	2.26e-38	73
ectoderm-derived structure	2.75e-38	95
ectoderm	2.75e-38	95
presumptive ectoderm	2.75e-38	95
neurectoderm	8.74e-28	64
neural plate	8.74e-28	64
presumptive neural plate	8.74e-28	64
ecto-epithelium	1.37e-26	73
regional part of nervous system	1.96e-26	54
neural tube	2.92e-25	52
neural rod	2.92e-25	52
future spinal cord	2.92e-25	52
neural keel	2.92e-25	52
brain	8.89e-22	47
future brain	8.89e-22	47
regional part of brain	3.18e-21	46
pre-chordal neural plate	6.17e-19	49
anterior neural tube	3.60e-18	40
regional part of forebrain	8.57e-18	39
forebrain	8.57e-18	39
future forebrain	8.57e-18	39
structure with developmental contribution from neural crest	3.58e-17	92
gray matter	4.12e-17	34
brain grey matter	6.95e-14	29
regional part of telencephalon	6.95e-14	29
telencephalon	6.95e-14	29
cerebral cortex	1.55e-09	21
cerebral hemisphere	1.55e-09	21
pallium	1.55e-09	21
posterior neural tube	1.12e-07	12
chordal neural plate	1.12e-07	12
regional part of cerebral cortex	2.82e-07	17
organ system subdivision	6.62e-07	194

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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