MCL coexpression mm9:1389

Phase1 CAGE Peaks

	Short description
Mm9::chr16:93929757..93929773,-	p1@Cldn14
Mm9::chr1:132544045..132544050,-	p@chr1:132544045..132544050 -
Mm9::chr1:132558130..132558141,-	p6@C4bp
Mm9::chr1:132558142..132558160,-	p5@C4bp
Mm9::chr8:108659842..108659853,+	p@chr8:108659842..108659853 +
Mm9::chr9:48148735..48148751,-	p6@Fam55b

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0006958	complement activation, classical pathway	0.0330562534615398
GO:0002455	humoral immune response mediated by circulating immunoglobulin	0.0330562534615398
GO:0002541	activation of plasma proteins during acute inflammatory response	0.0330562534615398
GO:0006956	complement activation	0.0330562534615398
GO:0005923	tight junction	0.0330562534615398
GO:0016064	immunoglobulin mediated immune response	0.0330562534615398
GO:0019724	B cell mediated immunity	0.0330562534615398
GO:0002526	acute inflammatory response	0.0330562534615398
GO:0002253	activation of immune response	0.0330562534615398
GO:0043296	apical junction complex	0.0330562534615398
GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	0.0330562534615398
GO:0045087	innate immune response	0.0330562534615398
GO:0002250	adaptive immune response	0.0330562534615398
GO:0016327	apicolateral plasma membrane	0.0330562534615398
GO:0002449	lymphocyte mediated immunity	0.0330562534615398
GO:0050778	positive regulation of immune response	0.0330562534615398
GO:0002684	positive regulation of immune system process	0.0330562534615398
GO:0002443	leukocyte mediated immunity	0.0330562534615398
GO:0050776	regulation of immune response	0.0334689993924092
GO:0002682	regulation of immune system process	0.0334689993924092
GO:0051240	positive regulation of multicellular organismal process	0.0334689993924092
GO:0002252	immune effector process	0.0355026203106886
GO:0006959	humoral immune response	0.0355026203106886
GO:0005911	intercellular junction	0.0375113022889046
GO:0006954	inflammatory response	0.0498553802887337

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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