MCL coexpression mm9:833

Phase1 CAGE Peaks

	Short description
Mm9::chr16:85080106..85080121,-	p@chr16:85080106..85080121 -
Mm9::chr16:85080128..85080143,-	p@chr16:85080128..85080143 -
Mm9::chr16:85080172..85080187,-	p@chr16:85080172..85080187 -
Mm9::chr16:85120817..85120847,-	p@chr16:85120817..85120847 -
Mm9::chr2:121129145..121129157,+	p@chr2:121129145..121129157 +
Mm9::chr4:149022062..149022065,+	p@chr4:149022062..149022065 +
Mm9::chr5:136387216..136387230,-	p@chr5:136387216..136387230 -
Mm9::chr7:17501688..17501702,-	p@chr7:17501688..17501702 -
Mm9::chr9:109906142..109906146,+	p@chr9:109906142..109906146 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0006874	cellular calcium ion homeostasis	0.00273189028276919
GO:0055074	calcium ion homeostasis	0.00273189028276919
GO:0006875	cellular metal ion homeostasis	0.00273189028276919
GO:0055065	metal ion homeostasis	0.00273189028276919
GO:0030005	cellular di-, tri-valent inorganic cation homeostasis	0.00339561591060371
GO:0055066	di-, tri-valent inorganic cation homeostasis	0.00339561591060371
GO:0030003	cellular cation homeostasis	0.00339561591060371
GO:0055080	cation homeostasis	0.00339561591060371
GO:0051233	spindle midzone	0.00421926693595706
GO:0048669	collateral sprouting in the absence of injury	0.00421926693595706
GO:0006873	cellular ion homeostasis	0.00421926693595706
GO:0055082	cellular chemical homeostasis	0.00421926693595706
GO:0050801	ion homeostasis	0.00461903084077554
GO:0007268	synaptic transmission	0.00461903084077554
GO:0032469	endoplasmic reticulum calcium ion homeostasis	0.00461903084077554
GO:0016199	axon midline choice point recognition	0.00461903084077554
GO:0051563	smooth endoplasmic reticulum calcium ion homeostasis	0.00461903084077554
GO:0051319	G2 phase	0.00461903084077554
GO:0000085	G2 phase of mitotic cell cycle	0.00461903084077554
GO:0048878	chemical homeostasis	0.0050343338130714
GO:0019725	cellular homeostasis	0.0050343338130714
GO:0019226	transmission of nerve impulse	0.00546315535128408
GO:0048668	collateral sprouting	0.00572326810172875
GO:0051124	synaptic growth at neuromuscular junction	0.00626799780861376
GO:0016198	axon choice point recognition	0.00626799780861376
GO:0016322	neuron remodeling	0.00626799780861376
GO:0045931	positive regulation of progression through mitotic cell cycle	0.00626799780861376
GO:0035235	ionotropic glutamate receptor signaling pathway	0.00626799780861376
GO:0042592	homeostatic process	0.00833950846167801
GO:0007267	cell-cell signaling	0.00833950846167801
GO:0001967	suckling behavior	0.00990585192898534
GO:0006378	mRNA polyadenylation	0.0106342712872807
GO:0006878	cellular copper ion homeostasis	0.0106342712872807
GO:0035253	ciliary rootlet	0.0106696132004251
GO:0055070	copper ion homeostasis	0.0106696132004251
GO:0007617	mating behavior	0.0106696132004251
GO:0042551	neuron maturation	0.0106696132004251
GO:0007215	glutamate signaling pathway	0.0112465543043183
GO:0008088	axon cargo transport	0.0112465543043183
GO:0043631	RNA polyadenylation	0.0120612685275445
GO:0045787	positive regulation of progression through cell cycle	0.0125305013899836
GO:0008038	neuron recognition	0.0125305013899836
GO:0031594	neuromuscular junction	0.0129569674991925
GO:0007618	mating	0.0129569674991925
GO:0031124	mRNA 3'-end processing	0.0130622824706538
GO:0044441	cilium part	0.0130622824706538
GO:0019098	reproductive behavior	0.0130622824706538
GO:0031123	RNA 3'-end processing	0.0155283450968913
GO:0007416	synaptogenesis	0.0159234052610371
GO:0022610	biological adhesion	0.0159234052610371
GO:0007155	cell adhesion	0.0159234052610371
GO:0065008	regulation of biological quality	0.0162361224778823
GO:0007528	neuromuscular junction development	0.0162361224778823
GO:0007346	regulation of progression through mitotic cell cycle	0.0162361224778823
GO:0051705	behavioral interaction between organisms	0.0169178940622229
GO:0007632	visual behavior	0.0169178940622229
GO:0008542	visual learning	0.0169178940622229
GO:0050803	regulation of synapse structure and activity	0.0173809901844654
GO:0007049	cell cycle	0.0192668237931291
GO:0005905	coated pit	0.0225298621556466
GO:0043169	cation binding	0.0225298621556466
GO:0050885	neuromuscular process controlling balance	0.0225298621556466
GO:0005509	calcium ion binding	0.0225298621556466
GO:0007631	feeding behavior	0.0232708228893785
GO:0048471	perinuclear region of cytoplasm	0.0235854233527861
GO:0005819	spindle	0.0252148981851856
GO:0016358	dendrite development	0.0254908050191597
GO:0046872	metal ion binding	0.025646726470486
GO:0051325	interphase	0.025646726470486
GO:0051329	interphase of mitotic cell cycle	0.025646726470486
GO:0008344	adult locomotory behavior	0.0259008044232371
GO:0043167	ion binding	0.0260312870700015
GO:0050808	synapse organization and biogenesis	0.0260312870700015
GO:0008037	cell recognition	0.0260312870700015
GO:0050905	neuromuscular process	0.0274308861076562
GO:0048589	developmental growth	0.0276443939001637
GO:0007612	learning	0.0278522937473146
GO:0007219	Notch signaling pathway	0.0280548013426924
GO:0040014	regulation of multicellular organism growth	0.0286456814313374
GO:0007154	cell communication	0.0286456814313374
GO:0005507	copper ion binding	0.0291705937692192
GO:0030198	extracellular matrix organization and biogenesis	0.0304106761431405
GO:0008201	heparin binding	0.0310950567036684
GO:0030534	adult behavior	0.0313892328921681
GO:0035264	multicellular organism growth	0.0313892328921681
GO:0030424	axon	0.0315311064098134
GO:0048741	skeletal muscle fiber development	0.0318050168723877
GO:0048747	muscle fiber development	0.0318050168723877
GO:0005929	cilium	0.0326716115387583
GO:0007611	learning and/or memory	0.0326716115387583
GO:0044463	cell projection part	0.0326716115387583
GO:0009416	response to light stimulus	0.0344083582451081
GO:0005539	glycosaminoglycan binding	0.0344083582451081
GO:0048469	cell maturation	0.0344083582451081
GO:0045177	apical part of cell	0.0354205845017605
GO:0007411	axon guidance	0.035958105758459
GO:0030247	polysaccharide binding	0.0364843466577046
GO:0007018	microtubule-based movement	0.03699965253807
GO:0007156	homophilic cell adhesion	0.0370651609049179
GO:0001871	pattern binding	0.0371293112372035
GO:0021700	developmental maturation	0.0393436810109145
GO:0009314	response to radiation	0.0398098077097394
GO:0007519	skeletal muscle development	0.0402666976046528
GO:0030705	cytoskeleton-dependent intracellular transport	0.041132097842153
GO:0043062	extracellular structure organization and biogenesis	0.0411538226977741
GO:0030900	forebrain development	0.0411750925299826
GO:0004867	serine-type endopeptidase inhibitor activity	0.0411959200989067
GO:0005515	protein binding	0.0435749539184473
GO:0045211	postsynaptic membrane	0.043624040836567
GO:0043005	neuron projection	0.0459858578633989
GO:0044456	synapse part	0.0474851397193773
GO:0014706	striated muscle development	0.0474851397193773

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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