Coexpression cluster:C3895

Full id: C3895_mature_Preadipocyte_extraskeletal_Fibroblast_adipose_Adipocyte_Olfactory

Phase1 CAGE Peaks

Hg19::chr1:162602303..162602315,+	p4@DDR2
Hg19::chr1:162602328..162602360,+	p3@DDR2
Hg19::chr5:32712363..32712425,+	p7@NPR3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0016941	natriuretic peptide receptor activity	0.00565171317555634
GO:0017046	peptide hormone binding	0.0254297146523079
GO:0007193	G-protein signaling, adenylate cyclase inhibiting pathway	0.0339017942465337
GO:0042562	hormone binding	0.0367226181792955
GO:0008217	regulation of blood pressure	0.0392242564109015
GO:0043168	anion binding	0.0392242564109015
GO:0031404	chloride ion binding	0.0392242564109015
GO:0004888	transmembrane receptor activity	0.0392242564109015
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger	0.0392242564109015
GO:0019933	cAMP-mediated signaling	0.0392242564109015
GO:0007166	cell surface receptor linked signal transduction	0.0392242564109015
GO:0007200	G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)	0.0392242564109015
GO:0004714	transmembrane receptor protein tyrosine kinase activity	0.0392242564109015
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	0.0392242564109015
GO:0019935	cyclic-nucleotide-mediated signaling	0.0392242564109015
GO:0019199	transmembrane receptor protein kinase activity	0.0392242564109015
GO:0048015	phosphoinositide-mediated signaling	0.0392242564109015
GO:0004872	receptor activity	0.0392242564109015
GO:0001653	peptide receptor activity	0.0392242564109015
GO:0008528	peptide receptor activity, G-protein coupled	0.0392242564109015
GO:0042803	protein homodimerization activity	0.0392242564109015
GO:0008015	blood circulation	0.0392242564109015
GO:0003013	circulatory system process	0.0392242564109015
GO:0060089	molecular transducer activity	0.0422574573003398
GO:0004871	signal transducer activity	0.0422574573003398
GO:0042277	peptide binding	0.0422574573003398
GO:0001501	skeletal development	0.0422574573003398
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	0.0422574573003398
GO:0008284	positive regulation of cell proliferation	0.0452535363805448

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
non-terminally differentiated cell	1.01e-32	180
fibroblast	1.24e-18	75
muscle precursor cell	2.05e-12	57
myoblast	2.05e-12	57
multi-potent skeletal muscle stem cell	2.05e-12	57
muscle cell	2.76e-11	54
fat cell	2.35e-10	15
electrically responsive cell	6.29e-09	60
electrically active cell	6.29e-09	60
skin fibroblast	9.18e-09	23
contractile cell	1.09e-08	59
smooth muscle cell	1.46e-08	42
smooth muscle myoblast	1.46e-08	42

Uber Anatomy

Ontology term	p-value	n
somite	2.90e-16	83
paraxial mesoderm	2.90e-16	83
presomitic mesoderm	2.90e-16	83
presumptive segmental plate	2.90e-16	83
trunk paraxial mesoderm	2.90e-16	83
presumptive paraxial mesoderm	2.90e-16	83
dermomyotome	6.89e-15	70
muscle tissue	5.93e-14	63
musculature	5.93e-14	63
musculature of body	5.93e-14	63
skeletal muscle tissue	1.46e-13	61
striated muscle tissue	1.46e-13	61
myotome	1.46e-13	61
organism subdivision	1.31e-12	365
multilaminar epithelium	1.27e-11	82
surface structure	3.23e-08	95
adult organism	3.86e-08	115
trunk mesenchyme	6.14e-08	143
integument	8.92e-08	45
integumental system	8.92e-08	45
adipose tissue	2.78e-07	14

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.