Coexpression cluster:C3116

Full id: C3116_pineal_Monocytederived_thyroid_colon_Cardiac_large_CD14

Phase1 CAGE Peaks

Hg19::chr11:130014326..130014476,+	p@chr11:130014326..130014476 +
Hg19::chr11:130014487..130014533,+	p@chr11:130014487..130014533 +
Hg19::chr11:130014534..130014545,+	p@chr11:130014534..130014545 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
monopoietic cell	5.55e-08	63
monocyte	5.55e-08	63
monoblast	5.55e-08	63
promonocyte	5.55e-08	63
CD14-positive, CD16-negative classical monocyte	5.96e-08	42
macrophage dendritic cell progenitor	4.86e-07	65

Uber Anatomy

Ontology term	p-value	n
multi-cellular organism	2.32e-12	659
embryo	1.03e-11	612
organ	2.05e-11	511
anatomical system	2.47e-11	625
anatomical group	2.82e-11	626
embryonic structure	1.15e-10	605
developing anatomical structure	1.15e-10	605
germ layer	2.35e-10	604
embryonic tissue	2.35e-10	604
presumptive structure	2.35e-10	604
epiblast (generic)	2.35e-10	604
tube	2.21e-07	194
neural tube	3.20e-07	57
neural rod	3.20e-07	57
future spinal cord	3.20e-07	57
neural keel	3.20e-07	57

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
ESRRA#2101	3	483.840314136126	8.75956906834516e-09	6.71689158538106e-07
FOXA1#3169	3	11.0814197493855	0.00073475527569867	0.00579497857111413
FOXA2#3170	2	16.4203091684435	0.00481068235210548	0.0225757292370948
HDAC2#3066	3	13.4156202366263	0.000414076139985721	0.00389811591706947
HNF4A#3172	3	23.1322903629537	8.07584663437677e-05	0.00122467452685883
HNF4G#3174	3	28.7534225264468	4.20470658818262e-05	0.000754917227717388
RXRA#6256	3	20.0746171391333	0.000123573034843222	0.001648255962451
SIN3A#25942	3	5.40888472681514	0.00631896197799152	0.0275459583445804
SP1#6667	3	5.6983813781409	0.00540396270171217	0.0245459253078814
TCF7L2#6934	3	10.7701765631373	0.000800318129839838	0.0061171271342464
USF1#7391	3	6.36149927720796	0.0038840405729056	0.0189553884763406

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.