Coexpression cluster:C3075

Full id: C3075_Endothelial_Renal_Smooth_Fibroblast_Mesothelial_Hepatic_Lymphatic

Phase1 CAGE Peaks

Hg19::chr11:103495901..103495904,-	p@chr11:103495901..103495904 -
Hg19::chr14:75422409..75422422,+	p@chr14:75422409..75422422 +
Hg19::chr7:134779508..134779514,-	p@chr7:134779508..134779514 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
endothelial cell of vascular tree	1.24e-32	24
endothelial cell	2.25e-32	35
lining cell	3.50e-29	57
barrier cell	3.50e-29	57
mesodermal cell	2.66e-27	119
blood vessel endothelial cell	6.18e-25	18
embryonic blood vessel endothelial progenitor cell	6.18e-25	18
meso-epithelial cell	2.34e-23	44
embryonic cell	1.11e-16	248
endothelial cell of artery	9.67e-14	9
squamous epithelial cell	3.33e-11	62
non-terminally differentiated cell	8.20e-11	180
aortic endothelial cell	1.30e-09	6
lymphangioblast	3.17e-09	6
endothelial cell of lymphatic vessel	3.17e-09	6
vascular lymphangioblast	3.17e-09	6
vein endothelial cell	6.02e-09	6
oligodendrocyte	6.22e-07	7
macroglial cell	6.22e-07	7
astrocyte	6.22e-07	7
oligodendrocyte precursor cell	6.22e-07	7

Uber Anatomy

Ontology term	p-value	n
vessel	6.14e-30	69
vasculature	6.46e-28	79
vascular system	6.46e-28	79
splanchnic layer of lateral plate mesoderm	1.02e-25	84
endothelium	6.18e-25	18
blood vessel endothelium	6.18e-25	18
cardiovascular system endothelium	6.18e-25	18
simple squamous epithelium	4.26e-24	22
cardiovascular system	7.83e-24	110
blood vessel	7.91e-24	60
epithelial tube open at both ends	7.91e-24	60
blood vasculature	7.91e-24	60
vascular cord	7.91e-24	60
circulatory system	1.07e-22	113
epithelial tube	2.40e-22	118
squamous epithelium	2.76e-20	25
anatomical conduit	6.44e-18	241
tube	1.65e-16	194
unilaminar epithelium	1.31e-15	138
artery	1.54e-15	42
arterial blood vessel	1.54e-15	42
arterial system	1.54e-15	42
cell layer	1.87e-15	312
anatomical cluster	6.43e-15	286
epithelium	7.27e-15	309
endothelial tube	9.67e-14	9
arterial system endothelium	9.67e-14	9
endothelium of artery	9.67e-14	9
systemic artery	1.03e-10	33
systemic arterial system	1.03e-10	33
lymphatic vessel	8.01e-09	8
lymph vasculature	8.01e-09	8
lymphatic part of lymphoid system	8.01e-09	8
aorta	1.49e-07	21
aortic system	1.49e-07	21
anatomical system	6.21e-07	625
anatomical group	7.24e-07	626

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.