Coexpression cluster:C1417

Full id: C1417_Mesenchymal_leiomyoblastoma_chorionic_alveolar_uterus_extraskeletal_mesenchymal

Phase1 CAGE Peaks

Hg19::chr15:96869114..96869160,+	p11@NR2F2
Hg19::chr15:96869165..96869183,+	p20@NR2F2
Hg19::chr15:96869206..96869220,+	p21@NR2F2
Hg19::chr15:96869222..96869251,+	p18@NR2F2
Hg19::chr15:96869255..96869291,+	p6@NR2F2
Hg19::chr15:96869292..96869320,+	p15@NR2F2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
contractile cell	2.25e-13	59
mesodermal cell	3.10e-13	119
muscle cell	1.99e-11	54
non-terminally differentiated cell	2.37e-11	180
smooth muscle cell	9.29e-11	42
smooth muscle myoblast	9.29e-11	42
muscle precursor cell	1.93e-10	57
myoblast	1.93e-10	57
multi-potent skeletal muscle stem cell	1.93e-10	57
vascular associated smooth muscle cell	2.68e-08	32
electrically responsive cell	3.74e-08	60
electrically active cell	3.74e-08	60
fibroblast	5.45e-08	75
embryonic cell	3.94e-07	248

Uber Anatomy

Ontology term	p-value	n
organism subdivision	1.63e-18	365
trunk	4.49e-18	216
multi-tissue structure	6.00e-16	347
cell layer	5.44e-13	312
epithelium	5.02e-12	309
vasculature	5.99e-12	79
vascular system	5.99e-12	79
trunk mesenchyme	6.77e-12	143
mesenchyme	1.20e-11	238
entire embryonic mesenchyme	1.20e-11	238
multi-cellular organism	1.20e-11	659
unilaminar epithelium	1.42e-11	138
splanchnic layer of lateral plate mesoderm	1.41e-10	84
muscle tissue	1.74e-10	63
musculature	1.74e-10	63
musculature of body	1.74e-10	63
skeletal muscle tissue	3.55e-10	61
striated muscle tissue	3.55e-10	61
myotome	3.55e-10	61
multilaminar epithelium	9.50e-10	82
anatomical conduit	1.97e-09	241
dermomyotome	2.04e-09	70
anatomical cluster	2.30e-09	286
epithelial tube	3.33e-09	118
body cavity precursor	3.36e-09	63
organ component layer	5.01e-09	57
anatomical system	9.20e-09	625
somite	9.70e-09	83
paraxial mesoderm	9.70e-09	83
presomitic mesoderm	9.70e-09	83
presumptive segmental plate	9.70e-09	83
trunk paraxial mesoderm	9.70e-09	83
presumptive paraxial mesoderm	9.70e-09	83
anatomical space	1.03e-08	104
vessel	1.13e-08	69
reproductive structure	1.32e-08	59
reproductive system	1.32e-08	59
anatomical group	1.50e-08	626
blood vessel	1.76e-08	60
epithelial tube open at both ends	1.76e-08	60
blood vasculature	1.76e-08	60
vascular cord	1.76e-08	60
artery	9.07e-08	42
arterial blood vessel	9.07e-08	42
arterial system	9.07e-08	42
body cavity	9.30e-08	46
anatomical cavity	1.86e-07	70
systemic artery	2.28e-07	33
systemic arterial system	2.28e-07	33
body cavity or lining	2.46e-07	49
immaterial anatomical entity	2.50e-07	126
renal system	4.59e-07	45
urinary system structure	5.70e-07	44
organ part	5.94e-07	219
cardiovascular system	7.43e-07	110
aorta	8.33e-07	21
aortic system	8.33e-07	21
circulatory system	8.47e-07	113

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
E2F1#1869	6	4.90738921487932	7.15746523583771e-05	0.00112713888987584
EP300#2033	5	5.64495143851933	0.000368813893181486	0.00366983176352717
GATA2#2624	6	12.744931733554	2.33109997620343e-07	1.22648740763078e-05
GATA3#2625	4	18.1576775714707	2.56597141799789e-05	0.000554724671753843
HDAC2#3066	4	8.9437468244175	0.000409407956530718	0.00390271609822121
POLR2A#5430	6	2.14745317655807	0.0101957067681878	0.03802283232147
SUZ12#23512	6	50.1157809110629	6.2866744827465e-11	6.98482974791024e-09
TCF7L2#6934	4	7.18011770875823	0.000955329712067973	0.0068747798386734
ZNF263#10127	6	8.22184163701068	3.23542093046082e-06	0.000108720761440283

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.