Coexpression cluster:C4629

Full id: C4629_salivary_parotid_submaxillary_Whole_stomach_thyroid_breast

Phase1 CAGE Peaks

Hg19::chr6:80341003..80341025,+	p2@SH3BGRL2
Hg19::chr6:80341039..80341052,+	p1@SH3BGRL2
Hg19::chr6:80411337..80411340,+	p6@SH3BGRL2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
adult organism	4.12e-52	115
central nervous system	2.11e-21	82
regional part of nervous system	4.23e-21	94
nervous system	4.23e-21	94
neural tube	1.59e-20	57
neural rod	1.59e-20	57
future spinal cord	1.59e-20	57
neural keel	1.59e-20	57
anatomical conduit	5.18e-19	241
regional part of brain	2.21e-18	59
anterior neural tube	2.94e-18	42
brain	4.07e-18	69
future brain	4.07e-18	69
regional part of forebrain	1.20e-17	41
forebrain	1.20e-17	41
future forebrain	1.20e-17	41
neural plate	2.79e-16	86
presumptive neural plate	2.79e-16	86
neurectoderm	3.07e-16	90
tube	6.95e-16	194
anatomical cluster	4.42e-15	286
gray matter	5.51e-15	34
brain grey matter	5.51e-15	34
telencephalon	6.70e-15	34
cerebral hemisphere	1.37e-14	32
regional part of telencephalon	2.58e-14	33
pre-chordal neural plate	2.59e-14	61
ectoderm	1.81e-13	173
presumptive ectoderm	1.81e-13	173
ectoderm-derived structure	2.63e-13	169
head	2.64e-13	123
anterior region of body	3.01e-13	129
craniocervical region	3.01e-13	129
regional part of cerebral cortex	1.36e-12	22
cerebral cortex	7.53e-12	25
pallium	7.53e-12	25
neocortex	1.12e-11	20
embryo	5.52e-11	612
multi-cellular organism	1.15e-10	659
epithelium	1.54e-10	309
cell layer	1.69e-10	312
multi-tissue structure	1.88e-09	347
embryonic structure	2.61e-09	605
developing anatomical structure	2.61e-09	605
germ layer	5.00e-09	604
embryonic tissue	5.00e-09	604
presumptive structure	5.00e-09	604
epiblast (generic)	5.00e-09	604
anatomical group	5.36e-09	626
anatomical system	6.61e-09	625
subdivision of digestive tract	1.25e-08	129
endodermal part of digestive tract	1.25e-08	129
digestive system	1.02e-07	155
digestive tract	1.02e-07	155
primitive gut	1.02e-07	155
organ part	1.23e-07	219
endoderm-derived structure	1.60e-07	169
endoderm	1.60e-07	169
presumptive endoderm	1.60e-07	169

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
FOXA2#3170	2	16.4203091684435	0.00481068235210548	0.0226001013976674
HNF4A#3172	2	15.4215269086358	0.00544421048668661	0.024691154204406
MAFF#23764	2	37.5435709932968	0.000934477401556032	0.0067718488302186
MAFK#7975	2	18.0671554252199	0.00398367474493681	0.0191182339254873
RXRA#6256	2	13.3830780927555	0.00719643442946573	0.0298391462354681
SIX5#147912	2	11.391143570306	0.00987382008142903	0.0370899505623266

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.