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Coexpression cluster:C1771: Difference between revisions

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|ontology_enrichment_disease=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0002390!3.46e-60!102;UBERON:0003061!3.46e-60!102;UBERON:0002193!6.24e-53!112;UBERON:0002371!6.47e-48!80;UBERON:0001474!2.22e-43!86;UBERON:0004765!6.14e-36!101;UBERON:0001434!6.14e-36!101;UBERON:0002405!1.45e-30!115;UBERON:0003081!1.17e-22!216;UBERON:0002204!1.00e-17!167;UBERON:0000178!9.46e-15!15;UBERON:0000179!9.46e-15!15;UBERON:0000463!9.46e-15!15;UBERON:0002384!1.21e-08!375
|ontology_enrichment_uberon=UBERON:0002390!3.46e-60!102;UBERON:0003061!3.46e-60!102;UBERON:0002193!6.24e-53!112;UBERON:0002371!6.47e-48!80;UBERON:0001474!2.22e-43!86;UBERON:0004765!6.14e-36!101;UBERON:0001434!6.14e-36!101;UBERON:0002405!1.45e-30!115;UBERON:0003081!1.17e-22!216;UBERON:0002204!1.00e-17!167;UBERON:0000178!9.46e-15!15;UBERON:0000179!9.46e-15!15;UBERON:0000463!9.46e-15!15;UBERON:0002384!1.21e-08!375
|tf_chipseq_enrich=MAFF#23764;2:22.5261425959781:0.00304181845127288:0.0160479125698367
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}}
}}

Revision as of 12:09, 5 September 2012


Full id: C1771_CD14_Neutrophils_Eosinophils_Peripheral_Whole_CD14CD16_blood



Phase1 CAGE Peaks

Hg19::chr16:8727024..8727043,+p@chr16:8727024..8727043
+
Hg19::chr1:150583889..150583898,-p@chr1:150583889..150583898
-
Hg19::chr20:46369846..46369868,+p@chr20:46369846..46369868
+
Hg19::chr22:30666830..30666847,-p@chr22:30666830..30666847
-
Hg19::chr2:219235586..219235598,+p@chr2:219235586..219235598
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
CD14-positive, CD16-negative classical monocyte3.70e-6942
myeloid leukocyte2.21e-6476
classical monocyte1.60e-6345
macrophage dendritic cell progenitor3.01e-5865
granulocyte monocyte progenitor cell3.68e-5671
monopoietic cell1.38e-5563
monocyte1.38e-5563
monoblast1.38e-5563
promonocyte1.38e-5563
myeloid lineage restricted progenitor cell1.52e-5270
leukocyte1.02e-47140
myeloid cell5.30e-44112
common myeloid progenitor5.30e-44112
hematopoietic stem cell6.45e-36172
angioblastic mesenchymal cell6.45e-36172
nongranular leukocyte1.54e-35119
hematopoietic lineage restricted progenitor cell4.12e-34124
hematopoietic cell1.01e-32182
hematopoietic oligopotent progenitor cell1.32e-31165
hematopoietic multipotent progenitor cell1.32e-31165
intermediate monocyte2.04e-159
CD14-positive, CD16-positive monocyte2.04e-159
granulocyte8.63e-118
mesenchymal cell1.68e-09358
connective tissue cell2.03e-09365
dendritic cell8.90e-0810
blood cell1.90e-0711
motile cell2.00e-07390
Uber Anatomy
Ontology termp-valuen
hematopoietic system3.46e-60102
blood island3.46e-60102
hemolymphoid system6.24e-53112
bone marrow6.47e-4880
bone element2.22e-4386
skeletal element6.14e-36101
skeletal system6.14e-36101
immune system1.45e-30115
lateral plate mesoderm1.17e-22216
musculoskeletal system1.00e-17167
blood9.46e-1515
haemolymphatic fluid9.46e-1515
organism substance9.46e-1515
connective tissue1.21e-08375


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
MAFF#23764222.52614259597810.003041818451272880.0160479125698367



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.