Coexpression cluster:C2550

Full id: C2550_Fibroblast_heart_Sebocyte_Mesenchymal_osteoclastoma_Mesothelial_Pericytes

Phase1 CAGE Peaks

Hg19::chr1:201708992..201709011,+	p6@NAV1
Hg19::chr1:201709014..201709019,+	p16@NAV1
Hg19::chr1:201709020..201709035,+	p1@NAV1
Hg19::chr1:201709054..201709065,+	p5@NAV1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
embryonic cell	6.78e-10	248
vascular associated smooth muscle cell	6.60e-09	32
mesodermal cell	1.52e-07	119

Uber Anatomy

Ontology term	p-value	n
cell layer	3.06e-25	312
epithelium	4.45e-24	309
tube	9.88e-22	194
anatomical conduit	3.20e-20	241
organism subdivision	1.14e-19	365
anatomical cluster	9.21e-18	286
neural plate	3.97e-16	86
presumptive neural plate	3.97e-16	86
regional part of brain	7.28e-16	59
splanchnic layer of lateral plate mesoderm	8.85e-15	84
vasculature	1.37e-14	79
vascular system	1.37e-14	79
neural tube	1.65e-14	57
neural rod	1.65e-14	57
future spinal cord	1.65e-14	57
neural keel	1.65e-14	57
neurectoderm	2.83e-14	90
ectoderm-derived structure	3.52e-14	169
multi-cellular organism	3.02e-13	659
head	3.24e-13	123
ectoderm	4.91e-13	173
presumptive ectoderm	4.91e-13	173
circulatory system	1.36e-12	113
brain	1.57e-12	69
future brain	1.57e-12	69
anterior region of body	2.58e-12	129
craniocervical region	2.58e-12	129
blood vessel	2.72e-12	60
epithelial tube open at both ends	2.72e-12	60
blood vasculature	2.72e-12	60
vascular cord	2.72e-12	60
central nervous system	3.57e-12	82
multi-tissue structure	7.05e-12	347
pre-chordal neural plate	9.46e-12	61
artery	1.41e-11	42
arterial blood vessel	1.41e-11	42
arterial system	1.41e-11	42
cardiovascular system	1.73e-11	110
adult organism	3.36e-11	115
regional part of nervous system	3.59e-11	94
nervous system	3.59e-11	94
epithelial tube	1.85e-10	118
anterior neural tube	2.01e-10	42
vessel	3.03e-10	69
regional part of forebrain	4.86e-10	41
forebrain	4.86e-10	41
future forebrain	4.86e-10	41
gray matter	1.86e-09	34
brain grey matter	1.86e-09	34
telencephalon	2.27e-09	34
regional part of telencephalon	3.77e-09	33
anatomical system	4.62e-09	625
anatomical group	5.40e-09	626
systemic artery	9.00e-09	33
systemic arterial system	9.00e-09	33
cerebral hemisphere	2.07e-08	32
primary circulatory organ	5.20e-08	27
embryo	6.56e-08	612
multilaminar epithelium	2.34e-07	82
organ part	3.11e-07	219
embryonic structure	3.24e-07	605
developing anatomical structure	3.24e-07	605
germ layer	4.03e-07	604
embryonic tissue	4.03e-07	604
presumptive structure	4.03e-07	604
epiblast (generic)	4.03e-07	604
compound organ	7.23e-07	69

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
TAF1#6872	4	3.34304628574529	0.00800566489870165	0.0322409145241778
TBP#6908	4	3.70677068709639	0.00529637781478435	0.0244377469670096
TCF7L2#6934	4	10.7701765631373	7.42969445082454e-05	0.00115485914384531

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.