Coexpression cluster:C346

Full id: C346_gall_ductus_seminal_temporal_duodenum_Hepatocyte_liver

Phase1 CAGE Peaks

Hg19::chr11:1036824..1036834,-	p12@MUC6
Hg19::chr11:1036870..1036877,-	p19@MUC6
Hg19::chr11:1247434..1247435,+	p@chr11:1247434..1247435 +
Hg19::chr11:1247439..1247442,+	p@chr11:1247439..1247442 +
Hg19::chr11:1247457..1247468,+	p@chr11:1247457..1247468 +
Hg19::chr11:1248306..1248342,+	p@chr11:1248306..1248342 +
Hg19::chr11:1248537..1248548,+	p@chr11:1248537..1248548 +
Hg19::chr11:69832005..69832020,+	p2@ENST00000534086
Hg19::chr11:69906080..69906083,+	p@chr11:69906080..69906083 +
Hg19::chr14:103470614..103470619,-	p17@CDC42BPB
Hg19::chr16:71560034..71560052,+	p2@CHST4
Hg19::chr16:71560158..71560170,+	p3@CHST4
Hg19::chr16:71560178..71560189,+	p4@CHST4
Hg19::chr16:71560323..71560348,+	p1@CHST4
Hg19::chr17:79429043..79429051,-	p@chr17:79429043..79429051 -
Hg19::chr18:3215101..3215129,-	p@chr18:3215101..3215129 -
Hg19::chr18:3215174..3215185,-	p@chr18:3215174..3215185 -
Hg19::chr18:3215199..3215210,-	p@chr18:3215199..3215210 -
Hg19::chr18:55095211..55095224,+	p@chr18:55095211..55095224 +
Hg19::chr19:40433829..40433855,-	p@chr19:40433829..40433855 -
Hg19::chr19:40434104..40434122,-	p@chr19:40434104..40434122 -
Hg19::chr1:116915270..116915282,+	p53@ATP1A1
Hg19::chr1:187929602..187929615,+	p@chr1:187929602..187929615 +
Hg19::chr1:22836627..22836645,+	p@chr1:22836627..22836645 +
Hg19::chr20:35983148..35983193,+	p@chr20:35983148..35983193 +
Hg19::chr21:43783664..43783667,+	p@chr21:43783664..43783667 +
Hg19::chr22:50732337..50732349,-	p@chr22:50732337..50732349 -
Hg19::chr3:193561585..193561593,-	p2@ENST00000439074
Hg19::chr3:193561605..193561612,-	p3@ENST00000439074
Hg19::chr3:193561630..193561644,-	p1@ENST00000439074
Hg19::chr4:26491064..26491072,-	p@chr4:26491064..26491072 -
Hg19::chr5:111570472..111570478,-	p@chr5:111570472..111570478 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0030277	maintenance of gastrointestinal epithelium	0.0207089471839206
GO:0001517	N-acetylglucosamine 6-O-sulfotransferase activity	0.0207089471839206
GO:0006928	cell motility	0.0207089471839206
GO:0051674	localization of cell	0.0207089471839206
GO:0031532	actin cytoskeleton reorganization	0.0207089471839206
GO:0051923	sulfation	0.0207089471839206
GO:0006477	protein amino acid sulfation	0.0207089471839206
GO:0005890	sodium:potassium-exchanging ATPase complex	0.0207089471839206
GO:0000287	magnesium ion binding	0.0207089471839206
GO:0030641	cellular hydrogen ion homeostasis	0.0258440314808478
GO:0030004	cellular monovalent inorganic cation homeostasis	0.0269172999760724
GO:0055067	monovalent inorganic cation homeostasis	0.0269172999760724
GO:0005391	sodium:potassium-exchanging ATPase activity	0.0281571499812529
GO:0022600	digestive system process	0.0282556773832283
GO:0030317	sperm motility	0.0282556773832283
GO:0005802	trans-Golgi network	0.0282556773832283
GO:0007163	establishment and/or maintenance of cell polarity	0.0367114937127861
GO:0006044	N-acetylglucosamine metabolic process	0.0396325799223194
GO:0006041	glucosamine metabolic process	0.0396325799223194
GO:0006040	amino sugar metabolic process	0.0440937139326096

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>

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Uber Anatomy

Ontology term	p-value	n
adult organism	2.90e-26	115
subdivision of digestive tract	1.32e-10	129
endodermal part of digestive tract	1.32e-10	129
digestive system	7.72e-09	155
digestive tract	7.72e-09	155
primitive gut	7.72e-09	155
endoderm-derived structure	1.12e-08	169
endoderm	1.12e-08	169
presumptive endoderm	1.12e-08	169
organ	2.49e-08	511
organ part	4.09e-08	219
mixed endoderm/mesoderm-derived structure	4.61e-08	130
male reproductive organ	6.77e-07	11

Disease

Ontology term	p-value	n
carcinoma	6.89e-11	106
cell type cancer	2.97e-07	143

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.