Coexpression cluster:C26: Difference between revisions
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|ontology_enrichment_disease= | |ontology_enrichment_disease= | ||
|ontology_enrichment_uberon=UBERON:0002390!2.32e-39!102;UBERON:0003061!2.32e-39!102;UBERON:0002193!7.34e-38!112;UBERON:0002371!4.68e-30!80;UBERON:0001474!4.27e-25!86;UBERON:0007023!5.81e-25!115;UBERON:0002405!1.14e-24!115;UBERON:0004765!4.79e-19!101;UBERON:0001434!4.79e-19!101;UBERON:0003081!5.43e-11!216;UBERON:0002384!1.56e-08!375;UBERON:0000178!1.23e-07!15;UBERON:0000179!1.23e-07!15;UBERON:0000463!1.23e-07!15 | |ontology_enrichment_uberon=UBERON:0002390!2.32e-39!102;UBERON:0003061!2.32e-39!102;UBERON:0002193!7.34e-38!112;UBERON:0002371!4.68e-30!80;UBERON:0001474!4.27e-25!86;UBERON:0007023!5.81e-25!115;UBERON:0002405!1.14e-24!115;UBERON:0004765!4.79e-19!101;UBERON:0001434!4.79e-19!101;UBERON:0003081!5.43e-11!216;UBERON:0002384!1.56e-08!375;UBERON:0000178!1.23e-07!15;UBERON:0000179!1.23e-07!15;UBERON:0000463!1.23e-07!15 | ||
|pathway_enrichment=0.00210270397278665;0.0283643277689648;3;25;Nicotinate and nicotinamide metabolism (KEGG):00760!2.19470554783533e-05;0.000771804784322091;12;265;Cytokine-cytokine receptor interaction (KEGG):04060!0.00016032408551047;0.00338283820427091;9;189;Chemokine signaling pathway (KEGG):04062!0.000265683255398174;0.00509628789900134;7;121;Lysosome (KEGG):04142!9.41979212788425e-09;1.19254568339015e-06;13;156;Phagosome (KEGG):04145!0.00138780438603381;0.0204297715432419;4;47;Notch signaling pathway (KEGG):04330!1.38355162575075e-15;4.37894089550111e-13;18;128;Osteoclast differentiation (KEGG):04380!0.0041386555775396;0.0451684306996994;5;102;Toll-like receptor signaling pathway (KEGG):04620!0.00321584695640288;0.0391467523731351;4;59;NOD-like receptor signaling pathway (KEGG):04621!0.00021429850188657;0.00423909224044372;8;155;Jak-STAT signaling pathway (KEGG):04630!2.01409574227168e-08;1.59758257887329e-06;12;137;Natural killer cell mediated cytotoxicity (KEGG):04650!0.0010733031461005;0.0167141974071038;5;75;B cell receptor signaling pathway (KEGG):04662!0.000167841842169932;0.00342722213205054;6;79;Fc epsilon RI signaling pathway (KEGG):04664!5.8343161504992e-05;0.00175862958250762;7;95;Fc gamma R-mediated phagocytosis (KEGG):04666!0.0017726751998801;0.0249356311449801;8;214;Regulation of actin cytoskeleton (KEGG):04810!0.00217108722785528;0.0286312128173415;4;53;Amyotrophic lateral sclerosis (ALS) (KEGG):05014!6.29137107331061e-08;4.42493098822846e-06;9;73;Leishmaniasis (KEGG):05140!0.0044944671353932;0.0475224096999027;5;104;Chagas disease (American trypanosomiasis) (KEGG):05142!7.41536578885903e-05;0.0019030767731606;8;133;Toxoplasmosis (KEGG):05145!0.000116879046210597;0.00264230129468957;7;106;Amoebiasis (KEGG):05146!1.06512111842637e-07;6.74221667963894e-06;8;56;Staphylococcus aureus infection (KEGG):05150!3.49983290919671e-16;2.21539423152152e-13;21;182;Tuberculosis (KEGG):05152!7.81674503983818e-05;0.0019030767731606;8;134;Measles (KEGG):05162!9.34287433017998e-05;0.00219038498185331;9;176;Influenza A (KEGG):05164!0.00265478867993691;0.0336096246880012;5;92;Rheumatoid arthritis (KEGG):05323!5.58414603213884e-07;3.21342221667626e-05;8;69;IL-5 Signaling Pathway (Wikipathways):WP127!0.000752338728751996;0.0125323793500004;4;40;NOD pathway (Wikipathways):WP1433!0.0010825941448519;0.0167141974071038;3;20;Eicosanoid Synthesis (Wikipathways):WP167!7.11797888184495e-06;0.000300378708813857;10;161;B Cell Receptor Signaling Pathway (Wikipathways):WP23!0.0012799549587713;0.0192907497357675;4;46;Notch Signaling Pathway (Wikipathways):WP268!0.0041386555775396;0.0451684306996994;5;102;IL-3 Signaling Pathway (Wikipathways):WP286!0.000734767934485199;0.0125323793500004;5;69;Kit Receptor Signaling Pathway (Wikipathways):WP304!0.00346235995346592;0.0413523368027156;7;188;Focal Adhesion (Wikipathways):WP306!7.59006461325607e-05;0.0019030767731606;7;99;IL-6 Signaling Pathway (Wikipathways):WP364!0.00162222970345282;0.0233379864155826;4;49;Diurnally regulated genes with circadian orthologs (Wikipathways):WP410!0.000752338728751996;0.0125323793500004;4;40;G13 Signaling Pathway (Wikipathways):WP524!1.23152256122436e-05;0.000487221113284388;6;50;Type II interferon signaling (IFNG) (Wikipathways):WP619!1.44160653729474e-08;1.52089489684595e-06;12;133;T Cell Receptor Signaling Pathway (Wikipathways):WP69!0.0041386555775396;0.0451684306996994;5;102;Toll-like receptor signaling pathway (Wikipathways):WP75!1.93492498359097e-14;4.08269171537694e-12;30;511;Signaling in Immune system (Reactome):REACT_6900!0.00210604013450449;0.0283643277689648;8;220;Signalling by NGF (Reactome):REACT_11061!2.0190617110563e-08;1.59758257887329e-06;21;466;Hemostasis (Reactome):REACT_604!0.000295725248406183;0.00550570830120924;13;401;Transmembrane transport of small molecules (Reactome):REACT_15518!0.000880837521100879;0.0142966705347912;19;816;TGF beta receptor up reg. targets (Netpath):NetPath_7!3.03208345042419e-06;0.000147639140316808;23;740;TGF beta receptor down reg. targets (Netpath):NetPath_7!2.49214619662143e-05;0.000830278180242824;21;728;TNF alpha/NF-kB up reg. targets (Netpath):NetPath_9!6.6679280793151e-09;1.05519961855161e-06;16;246;B Cell Receptor up reg. targets (Netpath):NetPath_12!0.00289477132790361;0.0359292205992742;7;182;B Cell Receptor down reg. targets (Netpath):NetPath_12!7.26424414660834e-05;0.0019030767731606;6;68;T Cell Receptor down reg. targets (Netpath):NetPath_11!3.03130027733277e-06;0.000147639140316808;17;433;IL-2 up reg. targets (Netpath):NetPath_14!1.33593498908399e-05;0.000497439322405979;13;295;IL-2 down reg. targets (Netpath):NetPath_14!6.66379624582048e-05;0.0019030767731606;8;131;IL-5 up reg. targets (Netpath):NetPath_17!0.00357361785137221;0.0418907425910854;3;30;{FYN,30} (Static Module):NA!5.65840095958621e-06;0.000255840557672719;16;406;{GRB2,414} (Static Module):NA!0.00066068764862038;0.0119490080450486;3;17;{HCLS1,17} (Static Module):NA!3.06943049964634e-05;0.000971474753138067;7;86;{JUN,88} (Static Module):NA!0.000122995274538997;0.00268468995804087;3;10;{SPI1,10} (Static Module):NA!0.00450449381041732;0.0475224096999027;2;10;{TLE1,10} (Static Module):NA!0.00241230155738467;0.0311629976698876;5;90;{TRAF2,90} (Static Module):NA!0.00384805504905189;0.0442876153827245;4;62;{VAMP2,63} (Static Module):NA | |||
}} | }} |
Revision as of 14:59, 13 July 2012
Full id: C26_Eosinophils_Neutrophils_CD14_CD14CD16_Basophils_Monocytederived_Whole
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
p.value | FDR | nGenes | nPathway | Name |
---|---|---|---|---|
0.00210270397278665 | 0.0283643277689648 | 3 | 25 | Nicotinate and nicotinamide metabolism (KEGG):00760 |
2.19470554783533e-05 | 0.000771804784322091 | 12 | 265 | Cytokine-cytokine receptor interaction (KEGG):04060 |
0.00016032408551047 | 0.00338283820427091 | 9 | 189 | Chemokine signaling pathway (KEGG):04062 |
0.000265683255398174 | 0.00509628789900134 | 7 | 121 | Lysosome (KEGG):04142 |
9.41979212788425e-09 | 1.19254568339015e-06 | 13 | 156 | Phagosome (KEGG):04145 |
0.00138780438603381 | 0.0204297715432419 | 4 | 47 | Notch signaling pathway (KEGG):04330 |
1.38355162575075e-15 | 4.37894089550111e-13 | 18 | 128 | Osteoclast differentiation (KEGG):04380 |
0.0041386555775396 | 0.0451684306996994 | 5 | 102 | Toll-like receptor signaling pathway (KEGG):04620 |
0.00321584695640288 | 0.0391467523731351 | 4 | 59 | NOD-like receptor signaling pathway (KEGG):04621 |
0.00021429850188657 | 0.00423909224044372 | 8 | 155 | Jak-STAT signaling pathway (KEGG):04630 |
2.01409574227168e-08 | 1.59758257887329e-06 | 12 | 137 | Natural killer cell mediated cytotoxicity (KEGG):04650 |
0.0010733031461005 | 0.0167141974071038 | 5 | 75 | B cell receptor signaling pathway (KEGG):04662 |
0.000167841842169932 | 0.00342722213205054 | 6 | 79 | Fc epsilon RI signaling pathway (KEGG):04664 |
5.8343161504992e-05 | 0.00175862958250762 | 7 | 95 | Fc gamma R-mediated phagocytosis (KEGG):04666 |
0.0017726751998801 | 0.0249356311449801 | 8 | 214 | Regulation of actin cytoskeleton (KEGG):04810 |
0.00217108722785528 | 0.0286312128173415 | 4 | 53 | Amyotrophic lateral sclerosis (ALS) (KEGG):05014 |
6.29137107331061e-08 | 4.42493098822846e-06 | 9 | 73 | Leishmaniasis (KEGG):05140 |
0.0044944671353932 | 0.0475224096999027 | 5 | 104 | Chagas disease (American trypanosomiasis) (KEGG):05142 |
7.41536578885903e-05 | 0.0019030767731606 | 8 | 133 | Toxoplasmosis (KEGG):05145 |
0.000116879046210597 | 0.00264230129468957 | 7 | 106 | Amoebiasis (KEGG):05146 |
1.06512111842637e-07 | 6.74221667963894e-06 | 8 | 56 | Staphylococcus aureus infection (KEGG):05150 |
3.49983290919671e-16 | 2.21539423152152e-13 | 21 | 182 | Tuberculosis (KEGG):05152 |
7.81674503983818e-05 | 0.0019030767731606 | 8 | 134 | Measles (KEGG):05162 |
9.34287433017998e-05 | 0.00219038498185331 | 9 | 176 | Influenza A (KEGG):05164 |
0.00265478867993691 | 0.0336096246880012 | 5 | 92 | Rheumatoid arthritis (KEGG):05323 |
5.58414603213884e-07 | 3.21342221667626e-05 | 8 | 69 | IL-5 Signaling Pathway (Wikipathways):WP127 |
0.000752338728751996 | 0.0125323793500004 | 4 | 40 | NOD pathway (Wikipathways):WP1433 |
0.0010825941448519 | 0.0167141974071038 | 3 | 20 | Eicosanoid Synthesis (Wikipathways):WP167 |
7.11797888184495e-06 | 0.000300378708813857 | 10 | 161 | B Cell Receptor Signaling Pathway (Wikipathways):WP23 |
0.0012799549587713 | 0.0192907497357675 | 4 | 46 | Notch Signaling Pathway (Wikipathways):WP268 |
0.0041386555775396 | 0.0451684306996994 | 5 | 102 | IL-3 Signaling Pathway (Wikipathways):WP286 |
0.000734767934485199 | 0.0125323793500004 | 5 | 69 | Kit Receptor Signaling Pathway (Wikipathways):WP304 |
0.00346235995346592 | 0.0413523368027156 | 7 | 188 | Focal Adhesion (Wikipathways):WP306 |
7.59006461325607e-05 | 0.0019030767731606 | 7 | 99 | IL-6 Signaling Pathway (Wikipathways):WP364 |
0.00162222970345282 | 0.0233379864155826 | 4 | 49 | Diurnally regulated genes with circadian orthologs (Wikipathways):WP410 |
0.000752338728751996 | 0.0125323793500004 | 4 | 40 | G13 Signaling Pathway (Wikipathways):WP524 |
1.23152256122436e-05 | 0.000487221113284388 | 6 | 50 | Type II interferon signaling (IFNG) (Wikipathways):WP619 |
1.44160653729474e-08 | 1.52089489684595e-06 | 12 | 133 | T Cell Receptor Signaling Pathway (Wikipathways):WP69 |
0.0041386555775396 | 0.0451684306996994 | 5 | 102 | Toll-like receptor signaling pathway (Wikipathways):WP75 |
1.93492498359097e-14 | 4.08269171537694e-12 | 30 | 511 | Signaling in Immune system (Reactome):REACT_6900 |
0.00210604013450449 | 0.0283643277689648 | 8 | 220 | Signalling by NGF (Reactome):REACT_11061 |
2.0190617110563e-08 | 1.59758257887329e-06 | 21 | 466 | Hemostasis (Reactome):REACT_604 |
0.000295725248406183 | 0.00550570830120924 | 13 | 401 | Transmembrane transport of small molecules (Reactome):REACT_15518 |
0.000880837521100879 | 0.0142966705347912 | 19 | 816 | TGF beta receptor up reg. targets (Netpath):NetPath_7 |
3.03208345042419e-06 | 0.000147639140316808 | 23 | 740 | TGF beta receptor down reg. targets (Netpath):NetPath_7 |
2.49214619662143e-05 | 0.000830278180242824 | 21 | 728 | TNF alpha/NF-kB up reg. targets (Netpath):NetPath_9 |
6.6679280793151e-09 | 1.05519961855161e-06 | 16 | 246 | B Cell Receptor up reg. targets (Netpath):NetPath_12 |
0.00289477132790361 | 0.0359292205992742 | 7 | 182 | B Cell Receptor down reg. targets (Netpath):NetPath_12 |
7.26424414660834e-05 | 0.0019030767731606 | 6 | 68 | T Cell Receptor down reg. targets (Netpath):NetPath_11 |
3.03130027733277e-06 | 0.000147639140316808 | 17 | 433 | IL-2 up reg. targets (Netpath):NetPath_14 |
1.33593498908399e-05 | 0.000497439322405979 | 13 | 295 | IL-2 down reg. targets (Netpath):NetPath_14 |
6.66379624582048e-05 | 0.0019030767731606 | 8 | 131 | IL-5 up reg. targets (Netpath):NetPath_17 |
0.00357361785137221 | 0.0418907425910854 | 3 | 30 | {FYN,30} (Static Module):NA |
5.65840095958621e-06 | 0.000255840557672719 | 16 | 406 | {GRB2,414} (Static Module):NA |
0.00066068764862038 | 0.0119490080450486 | 3 | 17 | {HCLS1,17} (Static Module):NA |
3.06943049964634e-05 | 0.000971474753138067 | 7 | 86 | {JUN,88} (Static Module):NA |
0.000122995274538997 | 0.00268468995804087 | 3 | 10 | {SPI1,10} (Static Module):NA |
0.00450449381041732 | 0.0475224096999027 | 2 | 10 | {TLE1,10} (Static Module):NA |
0.00241230155738467 | 0.0311629976698876 | 5 | 90 | {TRAF2,90} (Static Module):NA |
0.00384805504905189 | 0.0442876153827245 | 4 | 62 | {VAMP2,63} (Static Module):NA |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0002376 | immune system process | 1.20118765244635e-23 |
GO:0005515 | protein binding | 1.09182905839681e-19 |
GO:0006955 | immune response | 2.029161774243e-19 |
GO:0006952 | defense response | 1.57236611920896e-17 |
GO:0005887 | integral to plasma membrane | 3.56951470544992e-16 |
GO:0031226 | intrinsic to plasma membrane | 6.58892987557053e-16 |
GO:0005886 | plasma membrane | 5.00885807174355e-14 |
GO:0051707 | response to other organism | 5.26086446105106e-13 |
GO:0016020 | membrane | 3.34784429214969e-12 |
GO:0044459 | plasma membrane part | 9.09884578843473e-12 |
GO:0005737 | cytoplasm | 3.2477965828267e-11 |
GO:0044464 | cell part | 8.02708375563169e-11 |
GO:0009607 | response to biotic stimulus | 1.48101209081076e-10 |
GO:0001816 | cytokine production | 4.86036389190393e-10 |
GO:0007154 | cell communication | 1.14911911228074e-09 |
GO:0051704 | multi-organism process | 1.43405977852945e-09 |
GO:0045184 | establishment of protein localization | 1.68319336975749e-09 |
GO:0007165 | signal transduction | 1.89103188637165e-09 |
GO:0007242 | intracellular signaling cascade | 4.18546939172051e-09 |
GO:0044425 | membrane part | 5.3916656987842e-09 |
GO:0008104 | protein localization | 7.16002997453345e-09 |
GO:0009611 | response to wounding | 8.62140678502574e-09 |
GO:0009605 | response to external stimulus | 1.01206693116221e-08 |
GO:0033036 | macromolecule localization | 4.46744067389888e-08 |
GO:0006954 | inflammatory response | 6.713796191904e-08 |
GO:0008219 | cell death | 9.24553325759189e-08 |
GO:0016265 | death | 9.24553325759189e-08 |
GO:0002224 | toll-like receptor signaling pathway | 1.83829980638352e-07 |
GO:0002221 | pattern recognition receptor signaling pathway | 1.83829980638352e-07 |
GO:0015031 | protein transport | 1.83829980638352e-07 |
GO:0048518 | positive regulation of biological process | 1.95055140581875e-07 |
GO:0002757 | immune response-activating signal transduction | 2.02315113322484e-07 |
GO:0006968 | cellular defense response | 2.05300331420288e-07 |
GO:0004871 | signal transducer activity | 2.05300331420288e-07 |
GO:0060089 | molecular transducer activity | 2.05300331420288e-07 |
GO:0031224 | intrinsic to membrane | 2.17191454593406e-07 |
GO:0002764 | immune response-regulating signal transduction | 2.20650733110649e-07 |
GO:0045089 | positive regulation of innate immune response | 2.63106641089538e-07 |
GO:0016021 | integral to membrane | 3.82799220987116e-07 |
GO:0045088 | regulation of innate immune response | 4.55401929819083e-07 |
GO:0002218 | activation of innate immune response | 6.47712420688381e-07 |
GO:0002758 | innate immune response-activating signal transduction | 6.47712420688381e-07 |
GO:0048519 | negative regulation of biological process | 6.86070417659224e-07 |
GO:0050778 | positive regulation of immune response | 6.96647715698022e-07 |
GO:0002684 | positive regulation of immune system process | 7.55780107013146e-07 |
GO:0048523 | negative regulation of cellular process | 1.29406789978908e-06 |
GO:0048869 | cellular developmental process | 1.3567904047578e-06 |
GO:0030154 | cell differentiation | 1.3567904047578e-06 |
GO:0010324 | membrane invagination | 1.40595791697428e-06 |
GO:0006897 | endocytosis | 1.40595791697428e-06 |
GO:0016044 | membrane organization and biogenesis | 1.4693502251562e-06 |
GO:0044424 | intracellular part | 1.98066256929885e-06 |
GO:0050776 | regulation of immune response | 1.99125449206432e-06 |
GO:0009615 | response to virus | 1.99125449206432e-06 |
GO:0065008 | regulation of biological quality | 2.06335561628644e-06 |
GO:0002253 | activation of immune response | 2.10149708532329e-06 |
GO:0002682 | regulation of immune system process | 2.25044970328901e-06 |
GO:0001775 | cell activation | 2.32009246701787e-06 |
GO:0051240 | positive regulation of multicellular organismal process | 3.32325264158938e-06 |
GO:0009617 | response to bacterium | 3.54760547615533e-06 |
GO:0045321 | leukocyte activation | 4.11892626337132e-06 |
GO:0065007 | biological regulation | 4.50924138179558e-06 |
GO:0004872 | receptor activity | 4.57775819453697e-06 |
GO:0051239 | regulation of multicellular organismal process | 6.28479497352412e-06 |
GO:0012501 | programmed cell death | 6.8279559675677e-06 |
GO:0051179 | localization | 9.98301549557246e-06 |
GO:0032760 | positive regulation of tumor necrosis factor production | 1.08826606128751e-05 |
GO:0048468 | cell development | 1.29710139430562e-05 |
GO:0048522 | positive regulation of cellular process | 1.30046162066149e-05 |
GO:0001817 | regulation of cytokine production | 1.56700106360984e-05 |
GO:0001819 | positive regulation of cytokine production | 1.734346092045e-05 |
GO:0016192 | vesicle-mediated transport | 2.54008652693375e-05 |
GO:0051234 | establishment of localization | 3.71545828986038e-05 |
GO:0006915 | apoptosis | 3.78567362327851e-05 |
GO:0005773 | vacuole | 4.32524305198211e-05 |
GO:0032640 | tumor necrosis factor production | 4.87897918495313e-05 |
GO:0005622 | intracellular | 5.77263174891412e-05 |
GO:0045087 | innate immune response | 5.89359435272415e-05 |
GO:0007264 | small GTPase mediated signal transduction | 6.03929003349644e-05 |
GO:0002429 | immune response-activating cell surface receptor signaling pathway | 6.24164023815124e-05 |
GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 7.30463586104659e-05 |
GO:0005764 | lysosome | 7.31162264981264e-05 |
GO:0032502 | developmental process | 7.40252369562258e-05 |
GO:0000323 | lytic vacuole | 7.45976380675629e-05 |
GO:0032680 | regulation of tumor necrosis factor production | 8.28681065709088e-05 |
GO:0019961 | interferon binding | 8.28681065709088e-05 |
GO:0004904 | interferon receptor activity | 8.28681065709088e-05 |
GO:0050878 | regulation of body fluid levels | 0.000103917413123012 |
GO:0032501 | multicellular organismal process | 0.000166433145305134 |
GO:0006950 | response to stress | 0.00017107320303156 |
GO:0006810 | transport | 0.000186794483038511 |
GO:0019955 | cytokine binding | 0.000201945177289229 |
GO:0009620 | response to fungus | 0.000208518076822058 |
GO:0043235 | receptor complex | 0.000393614568367592 |
GO:0046649 | lymphocyte activation | 0.00046295469679559 |
GO:0050789 | regulation of biological process | 0.000463748905889363 |
GO:0008283 | cell proliferation | 0.000463748905889363 |
GO:0045934 | negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.000632316496660832 |
GO:0050854 | regulation of antigen receptor-mediated signaling pathway | 0.000841095174793124 |
GO:0002237 | response to molecule of bacterial origin | 0.000841095174793124 |
GO:0042221 | response to chemical stimulus | 0.000850493647253148 |
GO:0008047 | enzyme activator activity | 0.000850493647253148 |
GO:0019964 | interferon-gamma binding | 0.000904235788854328 |
GO:0002238 | response to molecule of fungal origin | 0.000904235788854328 |
GO:0032765 | positive regulation of mast cell cytokine production | 0.000904235788854328 |
GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | 0.000904235788854328 |
GO:0004906 | interferon-gamma receptor activity | 0.000904235788854328 |
GO:0051091 | positive regulation of transcription factor activity | 0.00118882322638526 |
GO:0016481 | negative regulation of transcription | 0.00131876519881436 |
GO:0043227 | membrane-bound organelle | 0.00139139368469882 |
GO:0007249 | I-kappaB kinase/NF-kappaB cascade | 0.00148346196141786 |
GO:0042110 | T cell activation | 0.00159795366421067 |
GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade | 0.00167538647739106 |
GO:0007596 | blood coagulation | 0.00175557783622935 |
GO:0019899 | enzyme binding | 0.00183680570260926 |
GO:0005829 | cytosol | 0.00185812970643557 |
GO:0050817 | coagulation | 0.0019080314001248 |
GO:0009892 | negative regulation of metabolic process | 0.00201920236851201 |
GO:0001776 | leukocyte homeostasis | 0.00209623465111779 |
GO:0007599 | hemostasis | 0.0021817209423024 |
GO:0007243 | protein kinase cascade | 0.00219179762744337 |
GO:0042089 | cytokine biosynthetic process | 0.00219179762744337 |
GO:0043231 | intracellular membrane-bound organelle | 0.00219179762744337 |
GO:0044444 | cytoplasmic part | 0.00221579715088772 |
GO:0042107 | cytokine metabolic process | 0.00231016553811391 |
GO:0000267 | cell fraction | 0.00233132503894854 |
GO:0031324 | negative regulation of cellular metabolic process | 0.00233132503894854 |
GO:0009967 | positive regulation of signal transduction | 0.00233132503894854 |
GO:0043122 | regulation of I-kappaB kinase/NF-kappaB cascade | 0.00233132503894854 |
GO:0030029 | actin filament-based process | 0.00233132503894854 |
GO:0004896 | hematopoietin/interferon-class (D200-domain) cytokine receptor activity | 0.00233132503894854 |
GO:0032635 | interleukin-6 production | 0.00233132503894854 |
GO:0048872 | homeostasis of number of cells | 0.00233132503894854 |
GO:0050794 | regulation of cellular process | 0.00261900285596442 |
GO:0009893 | positive regulation of metabolic process | 0.00276099271238151 |
GO:0030048 | actin filament-based movement | 0.00276993141392856 |
GO:0019865 | immunoglobulin binding | 0.00276993141392856 |
GO:0006909 | phagocytosis | 0.00321999849278881 |
GO:0022603 | regulation of anatomical structure morphogenesis | 0.00346256585009687 |
GO:0008360 | regulation of cell shape | 0.00346256585009687 |
GO:0022604 | regulation of cell morphogenesis | 0.00346256585009687 |
GO:0001726 | ruffle | 0.00376833921483665 |
GO:0051649 | establishment of cellular localization | 0.00387925819966616 |
GO:0043226 | organelle | 0.00387925819966616 |
GO:0032762 | mast cell cytokine production | 0.00393631980094903 |
GO:0032763 | regulation of mast cell cytokine production | 0.00393631980094903 |
GO:0006366 | transcription from RNA polymerase II promoter | 0.00490785082406937 |
GO:0050663 | cytokine secretion | 0.00510372768786045 |
GO:0051247 | positive regulation of protein metabolic process | 0.00549265797319925 |
GO:0031982 | vesicle | 0.00568668973622424 |
GO:0042060 | wound healing | 0.00568668973622424 |
GO:0051641 | cellular localization | 0.00568668973622424 |
GO:0009966 | regulation of signal transduction | 0.00568668973622424 |
GO:0031325 | positive regulation of cellular metabolic process | 0.00570935644568082 |
GO:0043229 | intracellular organelle | 0.0058600453291888 |
GO:0030036 | actin cytoskeleton organization and biogenesis | 0.00692056459963043 |
GO:0051090 | regulation of transcription factor activity | 0.00708762945419995 |
GO:0030595 | leukocyte chemotaxis | 0.00725700204255904 |
GO:0051092 | activation of NF-kappaB transcription factor | 0.00725700204255904 |
GO:0005768 | endosome | 0.00757070727003222 |
GO:0042742 | defense response to bacterium | 0.00844434905875339 |
GO:0002720 | positive regulation of cytokine production during immune response | 0.00867303804046271 |
GO:0002702 | positive regulation of production of molecular mediator of immune response | 0.00867303804046271 |
GO:0050856 | regulation of T cell receptor signaling pathway | 0.00867303804046271 |
GO:0016043 | cellular component organization and biogenesis | 0.00969188158235719 |
GO:0042127 | regulation of cell proliferation | 0.0101616641858054 |
GO:0050851 | antigen receptor-mediated signaling pathway | 0.0110922639012538 |
GO:0002274 | myeloid leukocyte activation | 0.0110922639012538 |
GO:0042035 | regulation of cytokine biosynthetic process | 0.011310648108726 |
GO:0005123 | death receptor binding | 0.0116549966605453 |
GO:0008154 | actin polymerization and/or depolymerization | 0.0118921896988637 |
GO:0045941 | positive regulation of transcription | 0.0137133861946189 |
GO:0005794 | Golgi apparatus | 0.0139341140580002 |
GO:0042325 | regulation of phosphorylation | 0.0139791191987268 |
GO:0042981 | regulation of apoptosis | 0.0143637554832046 |
GO:0002252 | immune effector process | 0.0143637554832046 |
GO:0051246 | regulation of protein metabolic process | 0.0143637554832046 |
GO:0019864 | IgG binding | 0.0143637554832046 |
GO:0032606 | interferon type I production | 0.0143637554832046 |
GO:0045576 | mast cell activation | 0.0143637554832046 |
GO:0005031 | tumor necrosis factor receptor activity | 0.0143637554832046 |
GO:0016045 | detection of bacterium | 0.0143637554832046 |
GO:0045351 | interferon type I biosynthetic process | 0.0143637554832046 |
GO:0031988 | membrane-bound vesicle | 0.0145142797470331 |
GO:0043067 | regulation of programmed cell death | 0.014938936187726 |
GO:0045893 | positive regulation of transcription, DNA-dependent | 0.0149752432356112 |
GO:0050900 | leukocyte migration | 0.0149752432356112 |
GO:0008285 | negative regulation of cell proliferation | 0.0155648488558152 |
GO:0045935 | positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0155648488558152 |
GO:0051174 | regulation of phosphorus metabolic process | 0.016822618890774 |
GO:0019220 | regulation of phosphate metabolic process | 0.016822618890774 |
GO:0030218 | erythrocyte differentiation | 0.0170693884444353 |
GO:0002700 | regulation of production of molecular mediator of immune response | 0.0170693884444353 |
GO:0043120 | tumor necrosis factor binding | 0.0170693884444353 |
GO:0002367 | cytokine production during immune response | 0.0170693884444353 |
GO:0042834 | peptidoglycan binding | 0.0170693884444353 |
GO:0002718 | regulation of cytokine production during immune response | 0.0170693884444353 |
GO:0015629 | actin cytoskeleton | 0.0172406774977119 |
GO:0003779 | actin binding | 0.0173168803048573 |
GO:0031252 | leading edge | 0.0187829569235703 |
GO:0005057 | receptor signaling protein activity | 0.0201930820884009 |
GO:0005095 | GTPase inhibitor activity | 0.0204015098784014 |
GO:0002260 | lymphocyte homeostasis | 0.0204015098784014 |
GO:0043621 | protein self-association | 0.0204015098784014 |
GO:0005035 | death receptor activity | 0.0204015098784014 |
GO:0007626 | locomotory behavior | 0.0220165075837084 |
GO:0006928 | cell motility | 0.022634251627448 |
GO:0051674 | localization of cell | 0.022634251627448 |
GO:0045646 | regulation of erythrocyte differentiation | 0.0237670833948128 |
GO:0008367 | bacterial binding | 0.0237670833948128 |
GO:0030228 | lipoprotein receptor activity | 0.0237670833948128 |
GO:0004185 | serine carboxypeptidase activity | 0.0237670833948128 |
GO:0002699 | positive regulation of immune effector process | 0.0237670833948128 |
GO:0005041 | low-density lipoprotein receptor activity | 0.0237670833948128 |
GO:0002526 | acute inflammatory response | 0.0244857410857003 |
GO:0007266 | Rho protein signal transduction | 0.0253186650100781 |
GO:0004715 | non-membrane spanning protein tyrosine kinase activity | 0.0269755922369315 |
GO:0008329 | pattern recognition receptor activity | 0.0274791503579048 |
GO:0042226 | interleukin-6 biosynthetic process | 0.0274791503579048 |
GO:0030593 | neutrophil chemotaxis | 0.0274791503579048 |
GO:0051605 | protein maturation via proteolysis | 0.0274791503579048 |
GO:0042108 | positive regulation of cytokine biosynthetic process | 0.0282916980507276 |
GO:0042592 | homeostatic process | 0.029620540858432 |
GO:0030866 | cortical actin cytoskeleton organization and biogenesis | 0.0317709787102618 |
GO:0019222 | regulation of metabolic process | 0.0317709787102618 |
GO:0006461 | protein complex assembly | 0.0349472916140101 |
GO:0030865 | cortical cytoskeleton organization and biogenesis | 0.0360677869904019 |
GO:0051604 | protein maturation | 0.0360677869904019 |
GO:0009595 | detection of biotic stimulus | 0.0360677869904019 |
GO:0005624 | membrane fraction | 0.0360677869904019 |
GO:0006935 | chemotaxis | 0.0360677869904019 |
GO:0042330 | taxis | 0.0360677869904019 |
GO:0045121 | lipid raft | 0.0371754496588662 |
GO:0003924 | GTPase activity | 0.0371754496588662 |
GO:0005096 | GTPase activator activity | 0.0383148415908638 |
GO:0031410 | cytoplasmic vesicle | 0.0383148415908638 |
GO:0002697 | regulation of immune effector process | 0.0383148415908638 |
GO:0050707 | regulation of cytokine secretion | 0.0383148415908638 |
GO:0030695 | GTPase regulator activity | 0.0383148415908638 |
GO:0046942 | carboxylic acid transport | 0.0383148415908638 |
GO:0008092 | cytoskeletal protein binding | 0.0383148415908638 |
GO:0016064 | immunoglobulin mediated immune response | 0.0383148415908638 |
GO:0015849 | organic acid transport | 0.0383148415908638 |
GO:0046983 | protein dimerization activity | 0.0383148415908638 |
GO:0050852 | T cell receptor signaling pathway | 0.0383148415908638 |
GO:0030169 | low-density lipoprotein binding | 0.0383148415908638 |
GO:0005637 | nuclear inner membrane | 0.0383148415908638 |
GO:0030130 | clathrin coat of trans-Golgi network vesicle | 0.0383148415908638 |
GO:0019724 | B cell mediated immunity | 0.0383148415908638 |
GO:0032403 | protein complex binding | 0.0383148415908638 |
GO:0007166 | cell surface receptor linked signal transduction | 0.0383148415908638 |
GO:0033032 | regulation of myeloid cell apoptosis | 0.0383148415908638 |
GO:0045554 | regulation of TRAIL biosynthetic process | 0.0383148415908638 |
GO:0033371 | T cell secretory granule organization and biogenesis | 0.0383148415908638 |
GO:0017001 | antibiotic catabolic process | 0.0383148415908638 |
GO:0004567 | beta-mannosidase activity | 0.0383148415908638 |
GO:0008917 | lipopolysaccharide N-acetylglucosaminyltransferase activity | 0.0383148415908638 |
GO:0006050 | mannosamine metabolic process | 0.0383148415908638 |
GO:0033367 | protein localization in mast cell secretory granule | 0.0383148415908638 |
GO:0033025 | regulation of mast cell apoptosis | 0.0383148415908638 |
GO:0008457 | beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity | 0.0383148415908638 |
GO:0009169 | purine ribonucleoside monophosphate catabolic process | 0.0383148415908638 |
GO:0009158 | ribonucleoside monophosphate catabolic process | 0.0383148415908638 |
GO:0009125 | nucleoside monophosphate catabolic process | 0.0383148415908638 |
GO:0030653 | beta-lactam antibiotic metabolic process | 0.0383148415908638 |
GO:0002752 | cell surface pattern recognition receptor signaling pathway | 0.0383148415908638 |
GO:0005350 | pyrimidine transmembrane transporter activity | 0.0383148415908638 |
GO:0001802 | type III hypersensitivity | 0.0383148415908638 |
GO:0045556 | positive regulation of TRAIL biosynthetic process | 0.0383148415908638 |
GO:0045545 | syndecan binding | 0.0383148415908638 |
GO:0015855 | pyrimidine transport | 0.0383148415908638 |
GO:0033024 | mast cell apoptosis | 0.0383148415908638 |
GO:0002905 | regulation of mature B cell apoptosis | 0.0383148415908638 |
GO:0001875 | lipopolysaccharide receptor activity | 0.0383148415908638 |
GO:0006051 | N-acetylmannosamine metabolic process | 0.0383148415908638 |
GO:0032498 | detection of muramyl dipeptide | 0.0383148415908638 |
GO:0030655 | beta-lactam antibiotic catabolic process | 0.0383148415908638 |
GO:0051076 | Gram-positive bacterial binding | 0.0383148415908638 |
GO:0045553 | TRAIL biosynthetic process | 0.0383148415908638 |
GO:0001866 | NK T cell proliferation | 0.0383148415908638 |
GO:0033026 | negative regulation of mast cell apoptosis | 0.0383148415908638 |
GO:0001787 | natural killer cell proliferation | 0.0383148415908638 |
GO:0009128 | purine nucleoside monophosphate catabolic process | 0.0383148415908638 |
GO:0030347 | syntaxin-2 binding | 0.0383148415908638 |
GO:0050855 | regulation of B cell receptor signaling pathway | 0.0383148415908638 |
GO:0032733 | positive regulation of interleukin-10 production | 0.0383148415908638 |
GO:0004051 | arachidonate 5-lipoxygenase activity | 0.0383148415908638 |
GO:0033375 | protease localization in T cell secretory granule | 0.0383148415908638 |
GO:0045127 | N-acetylglucosamine kinase activity | 0.0383148415908638 |
GO:0032639 | TRAIL production | 0.0383148415908638 |
GO:0030882 | lipid antigen binding | 0.0383148415908638 |
GO:0006196 | AMP catabolic process | 0.0383148415908638 |
GO:0033377 | maintenance of protein localization in T cell secretory granule | 0.0383148415908638 |
GO:0008800 | beta-lactamase activity | 0.0383148415908638 |
GO:0033028 | myeloid cell apoptosis | 0.0383148415908638 |
GO:0033365 | protein localization in organelle | 0.0383148415908638 |
GO:0032500 | muramyl dipeptide binding | 0.0383148415908638 |
GO:0033370 | maintenance of protein localization in mast cell secretory granule | 0.0383148415908638 |
GO:0015288 | porin activity | 0.0383148415908638 |
GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 0.0383148415908638 |
GO:0030884 | exogenous lipid antigen binding | 0.0383148415908638 |
GO:0001805 | positive regulation of type III hypersensitivity | 0.0383148415908638 |
GO:0033366 | protein localization in secretory granule | 0.0383148415908638 |
GO:0042892 | chloramphenicol transport | 0.0383148415908638 |
GO:0008513 | secondary active organic cation transmembrane transporter activity | 0.0383148415908638 |
GO:0033382 | maintenance of granzyme B localization in T cell secretory granule | 0.0383148415908638 |
GO:0033373 | maintenance of protease localization in mast cell secretory granule | 0.0383148415908638 |
GO:0033380 | granzyme B localization in T cell secretory granule | 0.0383148415908638 |
GO:0033379 | maintenance of protease localization in T cell secretory granule | 0.0383148415908638 |
GO:0033033 | negative regulation of myeloid cell apoptosis | 0.0383148415908638 |
GO:0005896 | interleukin-6 receptor complex | 0.0383148415908638 |
GO:0048006 | antigen processing and presentation, endogenous lipid antigen via MHC class Ib | 0.0383148415908638 |
GO:0002906 | negative regulation of mature B cell apoptosis | 0.0383148415908638 |
GO:0033364 | mast cell secretory granule organization and biogenesis | 0.0383148415908638 |
GO:0004218 | cathepsin S activity | 0.0383148415908638 |
GO:0001803 | regulation of type III hypersensitivity | 0.0383148415908638 |
GO:0033368 | protease localization in mast cell secretory granule | 0.0383148415908638 |
GO:0042891 | antibiotic transport | 0.0383148415908638 |
GO:0032490 | detection of molecule of bacterial origin | 0.0383148415908638 |
GO:0050861 | positive regulation of B cell receptor signaling pathway | 0.0383148415908638 |
GO:0032495 | response to muramyl dipeptide | 0.0383148415908638 |
GO:0030348 | syntaxin-3 binding | 0.0383148415908638 |
GO:0015734 | taurine transport | 0.0383148415908638 |
GO:0032499 | detection of peptidoglycan | 0.0383148415908638 |
GO:0033374 | protein localization in T cell secretory granule | 0.0383148415908638 |
GO:0002901 | mature B cell apoptosis | 0.0383148415908638 |
GO:0032494 | response to peptidoglycan | 0.0383148415908638 |
GO:0030881 | beta-2-microglobulin binding | 0.0383148415908638 |
GO:0033023 | mast cell homeostasis | 0.0383148415908638 |
GO:0008434 | vitamin D3 receptor activity | 0.0383148415908638 |
GO:0004187 | carboxypeptidase D activity | 0.0383148415908638 |
GO:0002431 | Fc receptor mediated stimulatory signaling pathway | 0.0383148415908638 |
GO:0006886 | intracellular protein transport | 0.0383148415908638 |
GO:0032943 | mononuclear cell proliferation | 0.0383148415908638 |
GO:0045727 | positive regulation of translation | 0.0383148415908638 |
GO:0030131 | clathrin adaptor complex | 0.0383148415908638 |
GO:0046651 | lymphocyte proliferation | 0.0383148415908638 |
GO:0030097 | hemopoiesis | 0.0393055798470624 |
GO:0030119 | AP-type membrane coat adaptor complex | 0.0399478438347448 |
GO:0006516 | glycoprotein catabolic process | 0.0399478438347448 |
GO:0019209 | kinase activator activity | 0.0399478438347448 |
GO:0012510 | trans-Golgi network transport vesicle membrane | 0.0399478438347448 |
GO:0008305 | integrin complex | 0.0416939217740311 |
GO:0046982 | protein heterodimerization activity | 0.0417941675612297 |
GO:0019905 | syntaxin binding | 0.0440391752151675 |
GO:0009306 | protein secretion | 0.0455905431133296 |
GO:0046903 | secretion | 0.0459302065463414 |
GO:0050793 | regulation of developmental process | 0.0463991328541862 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
hematopoietic stem cell | 1.07e-57 | 172 |
angioblastic mesenchymal cell | 1.07e-57 | 172 |
hematopoietic oligopotent progenitor cell | 9.17e-55 | 165 |
hematopoietic multipotent progenitor cell | 9.17e-55 | 165 |
leukocyte | 1.61e-54 | 140 |
hematopoietic cell | 8.49e-52 | 182 |
hematopoietic lineage restricted progenitor cell | 3.23e-45 | 124 |
nongranular leukocyte | 1.59e-43 | 119 |
myeloid cell | 1.74e-41 | 112 |
common myeloid progenitor | 1.74e-41 | 112 |
myeloid leukocyte | 1.27e-38 | 76 |
granulocyte monocyte progenitor cell | 6.85e-35 | 71 |
myeloid lineage restricted progenitor cell | 4.34e-33 | 70 |
macrophage dendritic cell progenitor | 4.64e-32 | 65 |
monopoietic cell | 5.03e-31 | 63 |
monocyte | 5.03e-31 | 63 |
monoblast | 5.03e-31 | 63 |
promonocyte | 5.03e-31 | 63 |
CD14-positive, CD16-negative classical monocyte | 9.47e-28 | 42 |
classical monocyte | 4.73e-25 | 45 |
lymphocyte | 1.29e-11 | 53 |
common lymphoid progenitor | 1.29e-11 | 53 |
lymphoid lineage restricted progenitor cell | 1.51e-11 | 52 |
mesenchymal cell | 3.06e-11 | 358 |
connective tissue cell | 1.13e-09 | 365 |
Ontology term | p-value | n |
---|---|---|
hematopoietic system | 2.32e-39 | 102 |
blood island | 2.32e-39 | 102 |
hemolymphoid system | 7.34e-38 | 112 |
bone marrow | 4.68e-30 | 80 |
bone element | 4.27e-25 | 86 |
adult organism | 5.81e-25 | 115 |
immune system | 1.14e-24 | 115 |
skeletal element | 4.79e-19 | 101 |
skeletal system | 4.79e-19 | 101 |
lateral plate mesoderm | 5.43e-11 | 216 |
connective tissue | 1.56e-08 | 375 |
blood | 1.23e-07 | 15 |
haemolymphatic fluid | 1.23e-07 | 15 |
organism substance | 1.23e-07 | 15 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
{{{tfbs_overrepresentation_jaspar}}} |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
"{{{coexpression_dpi_cluster_scores_median}}}" is not a number.