Coexpression cluster:C430

Full id: C430_acute_giant_chronic_CD34_CD133_melanoma_skeletal

Phase1 CAGE Peaks

Hg19::chr11:1918273..1918293,+	p@chr11:1918273..1918293 +
Hg19::chr11:1918296..1918324,+	p@chr11:1918296..1918324 +
Hg19::chr11:47611749..47611769,-	p@chr11:47611749..47611769 -
Hg19::chr13:44989025..44989034,-	p@chr13:44989025..44989034 -
Hg19::chr17:73494329..73494345,+	p@chr17:73494329..73494345 +
Hg19::chr19:853278..853299,+	p2@ELANE
Hg19::chr19:855662..855672,+	p6@ELANE
Hg19::chr19:856037..856044,+	p@chr19:856037..856044 +
Hg19::chr19:856109..856117,+	p@chr19:856109..856117 +
Hg19::chr1:243432977..243432992,+	p@chr1:243432977..243432992 +
Hg19::chr1:243433014..243433053,+	p@chr1:243433014..243433053 +
Hg19::chr1:35333189..35333201,-	p@chr1:35333189..35333201 -
Hg19::chr1:35333224..35333237,-	p@chr1:35333224..35333237 -
Hg19::chr1:45190613..45190615,-	p@chr1:45190613..45190615 -
Hg19::chr20:60881426..60881443,+	p@chr20:60881426..60881443 +
Hg19::chr20:60881449..60881460,+	p@chr20:60881449..60881460 +
Hg19::chr2:127851314..127851361,-	p@chr2:127851314..127851361 -
Hg19::chr3:129693504..129693519,+	p3@TRH
Hg19::chr3:129693523..129693541,+	p2@TRH
Hg19::chr7:29900040..29900050,+	p@chr7:29900040..29900050 +
Hg19::chr7:29900084..29900122,+	p@chr7:29900084..29900122 +
Hg19::chr7:29900130..29900140,+	p@chr7:29900130..29900140 +
Hg19::chr8:53062376..53062387,-	p@chr8:53062376..53062387 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008437	thyrotropin-releasing hormone activity	0.000618156128576475
GO:0007628	adult walking behavior	0.00206052042858825
GO:0009755	hormone-mediated signaling	0.00206052042858825
GO:0008344	adult locomotory behavior	0.00216354645001766
GO:0030534	adult behavior	0.00333804309431296
GO:0005184	neuropeptide hormone activity	0.00339985870717061
GO:0009725	response to hormone stimulus	0.00671140939597315
GO:0007626	locomotory behavior	0.0139857824090427
GO:0005179	hormone activity	0.0144648534086895
GO:0005625	soluble fraction	0.0144648534086895
GO:0007610	behavior	0.0165216274364985
GO:0009719	response to endogenous stimulus	0.0272503826680796
GO:0042221	response to chemical stimulus	0.0280072276716572
GO:0007267	cell-cell signaling	0.0282585658777817
GO:0000267	cell fraction	0.037171788531732
GO:0005102	receptor binding	0.0400642440833628

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
myeloid cell	1.41e-18	112
common myeloid progenitor	1.41e-18	112
CD14-positive, CD16-negative classical monocyte	3.03e-18	42
macrophage dendritic cell progenitor	2.17e-16	65
monopoietic cell	2.76e-16	63
monocyte	2.76e-16	63
monoblast	2.76e-16	63
promonocyte	2.76e-16	63
granulocyte monocyte progenitor cell	2.87e-16	71
classical monocyte	2.35e-15	45
myeloid leukocyte	2.46e-14	76
myeloid lineage restricted progenitor cell	2.81e-14	70
hematopoietic stem cell	3.91e-09	172
angioblastic mesenchymal cell	3.91e-09	172
hematopoietic cell	2.33e-08	182
hematopoietic oligopotent progenitor cell	7.76e-08	165
hematopoietic multipotent progenitor cell	7.76e-08	165

Uber Anatomy

Ontology term	p-value	n
adult organism	1.82e-23	115
neural tube	1.01e-17	57
neural rod	1.01e-17	57
future spinal cord	1.01e-17	57
neural keel	1.01e-17	57
central nervous system	6.82e-15	82
neural plate	6.89e-15	86
presumptive neural plate	6.89e-15	86
regional part of brain	1.52e-14	59
regional part of nervous system	3.27e-14	94
nervous system	3.27e-14	94
hematopoietic system	1.18e-13	102
blood island	1.18e-13	102
bone marrow	1.25e-13	80
neurectoderm	2.83e-13	90
brain	6.78e-13	69
future brain	6.78e-13	69
hemolymphoid system	1.42e-12	112
anterior neural tube	3.46e-12	42
regional part of forebrain	7.28e-12	41
forebrain	7.28e-12	41
future forebrain	7.28e-12	41
bone element	3.12e-11	86
immune system	8.14e-10	115
pre-chordal neural plate	9.61e-10	61
gray matter	1.13e-09	34
brain grey matter	1.13e-09	34
telencephalon	1.32e-09	34
regional part of telencephalon	2.56e-09	33
skeletal element	4.57e-09	101
skeletal system	4.57e-09	101
cerebral hemisphere	1.75e-08	32
lateral plate mesoderm	2.84e-07	216
posterior neural tube	5.94e-07	15
chordal neural plate	5.94e-07	15
neocortex	5.95e-07	20
cerebral cortex	8.98e-07	25
pallium	8.98e-07	25

Disease

Ontology term	p-value	n
myeloid leukemia	6.81e-08	31

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.