Coexpression cluster:C123

Full id: C123_CD19_Natural_CD8_CD4_CD14_Peripheral_Basophils

Phase1 CAGE Peaks

Hg19::chr10:12392687..12392699,-	p@chr10:12392687..12392699 -
Hg19::chr10:126432640..126432663,-	p4@FAM53B
Hg19::chr10:126432670..126432723,-	p3@FAM53B
Hg19::chr10:15139614..15139671,-	p1@C10orf111
Hg19::chr10:5727231..5727239,-	p1@AK126513
Hg19::chr11:113185382..113185393,+	p3@TTC12
Hg19::chr11:46639436..46639466,-	p2@HARBI1
Hg19::chr11:57509422..57509437,-	p@chr11:57509422..57509437 -
Hg19::chr11:58345505..58345516,-	p9@LPXN
Hg19::chr11:59437000..59437035,-	p5@PATL1
Hg19::chr11:62319223..62319248,-	p@chr11:62319223..62319248 -
Hg19::chr11:64052561..64052571,-	p12@BAD
Hg19::chr11:69065734..69065737,+	p@chr11:69065734..69065737 +
Hg19::chr12:106695911..106695928,+	p@chr12:106695911..106695928 +
Hg19::chr12:106695930..106695942,+	p@chr12:106695930..106695942 +
Hg19::chr12:106695946..106695967,+	p@chr12:106695946..106695967 +
Hg19::chr12:12510212..12510225,+	p6@LOH12CR1
Hg19::chr12:12510241..12510263,+	p4@LOH12CR1
Hg19::chr12:25538611..25538629,+	p@chr12:25538611..25538629 +
Hg19::chr12:25538639..25538657,+	p@chr12:25538639..25538657 +
Hg19::chr12:50135975..50135991,-	p@chr12:50135975..50135991 -
Hg19::chr12:65563183..65563201,-	p@chr12:65563183..65563201 -
Hg19::chr12:794806..794815,+	p@chr12:794806..794815 +
Hg19::chr13:28195482..28195491,-	p4@LNX2
Hg19::chr13:37575209..37575223,-	p@chr13:37575209..37575223 -
Hg19::chr13:52026813..52026829,-	p4@INTS6
Hg19::chr13:98087050..98087059,-	p@chr13:98087050..98087059 -
Hg19::chr14:52314077..52314088,-	p@chr14:52314077..52314088 -
Hg19::chr14:55518677..55518700,-	p@chr14:55518677..55518700 -
Hg19::chr14:55518707..55518734,-	p@chr14:55518707..55518734 -
Hg19::chr14:64971288..64971316,-	p2@ZBTB25
Hg19::chr14:64971346..64971357,-	p9@ZBTB25
Hg19::chr14:64971893..64971928,-	p8@ZBTB25
Hg19::chr14:75642741..75642766,+	p@chr14:75642741..75642766 +
Hg19::chr14:75642917..75642942,+	p@chr14:75642917..75642942 +
Hg19::chr14:90849734..90849772,+	p2@BC039305
Hg19::chr14:94547495..94547508,-	p2@DDX24
Hg19::chr15:50978554..50978560,+	p@chr15:50978554..50978560 +
Hg19::chr15:52471696..52471707,+	p@chr15:52471696..52471707 +
Hg19::chr15:72767490..72767526,-	p1@AK026340
Hg19::chr15:83478370..83478426,+	p1@WHAMM
Hg19::chr15:83478446..83478468,+	p2@WHAMM
Hg19::chr15:90809334..90809354,+	p7@NGRN
Hg19::chr16:2041391..2041393,+	p@chr16:2041391..2041393 +
Hg19::chr16:68298781..68298792,-	p@chr16:68298781..68298792 -
Hg19::chr17:38717290..38717301,+	p@chr17:38717290..38717301 +
Hg19::chr17:38717306..38717321,+	p@chr17:38717306..38717321 +
Hg19::chr17:41322948..41322969,-	p@chr17:41322948..41322969 -
Hg19::chr17:79819420..79819433,-	p@chr17:79819420..79819433 -
Hg19::chr17:80255928..80255943,-	p@chr17:80255928..80255943 -
Hg19::chr17:80255969..80255980,-	p@chr17:80255969..80255980 -
Hg19::chr18:11851018..11851036,+	p7@CHMP1B
Hg19::chr18:71815135..71815173,+	p@chr18:71815135..71815173 +
Hg19::chr19:10341278..10341304,+	p@chr19:10341278..10341304 +
Hg19::chr19:10347101..10347110,+	p@chr19:10347101..10347110 +
Hg19::chr19:10347111..10347120,+	p@chr19:10347111..10347120 +
Hg19::chr19:14486179..14486197,+	p@chr19:14486179..14486197 +
Hg19::chr19:37095638..37095647,-	p@chr19:37095638..37095647 -
Hg19::chr19:37095841..37095855,+	p2@ZNF382
Hg19::chr19:39881431..39881443,+	p@chr19:39881431..39881443 +
Hg19::chr19:40790530..40790546,+	p@chr19:40790530..40790546 +
Hg19::chr19:40790569..40790585,+	p@chr19:40790569..40790585 +
Hg19::chr1:112298075..112298090,-	p3@FAM212B
Hg19::chr1:115054310..115054326,+	p@chr1:115054310..115054326 +
Hg19::chr1:14029343..14029381,-	p@chr1:14029343..14029381 -
Hg19::chr1:14076759..14076771,+	p@chr1:14076759..14076771 +
Hg19::chr1:153606799..153606818,-	p8@S100A13
Hg19::chr1:156066892..156066941,-	p@chr1:156066892..156066941 -
Hg19::chr1:156067106..156067143,+	p1@AK123652
Hg19::chr1:171455154..171455177,-	p2@BC007549
Hg19::chr1:186344666..186344694,+	p4@C1orf27
Hg19::chr1:22109734..22109790,+	p@chr1:22109734..22109790 +
Hg19::chr1:2232091..2232125,+	p@chr1:2232091..2232125 +
Hg19::chr1:22352338..22352353,-	p@chr1:22352338..22352353 -
Hg19::chr1:228327553..228327587,-	p@chr1:228327553..228327587 -
Hg19::chr1:234744958..234745002,-	p8@IRF2BP2
Hg19::chr1:234745050..234745097,-	p1@IRF2BP2
Hg19::chr1:236959047..236959062,-	p@chr1:236959047..236959062 -
Hg19::chr20:23330784..23330836,+	p@chr20:23330784..23330836 +
Hg19::chr20:43992000..43992015,-	p@chr20:43992000..43992015 -
Hg19::chr20:5591145..5591173,+	p@chr20:5591145..5591173 +
Hg19::chr21:30398882..30398888,+	p@chr21:30398882..30398888 +
Hg19::chr21:43640357..43640399,-	p@chr21:43640357..43640399 -
Hg19::chr22:39097378..39097392,-	p10@JOSD1
Hg19::chr22:39097393..39097425,-	p7@JOSD1
Hg19::chr22:42336157..42336166,-	p8@CENPM
Hg19::chr22:42336209..42336228,-	p3@CENPM
Hg19::chr22:50629950..50629967,-	p@chr22:50629950..50629967 -
Hg19::chr2:113033704..113033722,-	p@chr2:113033704..113033722 -
Hg19::chr2:122406191..122406211,+	p@chr2:122406191..122406211 +
Hg19::chr2:201828138..201828160,+	p1@ENST00000332935
Hg19::chr2:202123105..202123116,-	p@chr2:202123105..202123116 -
Hg19::chr2:220144408..220144433,-	p@chr2:220144408..220144433 -
Hg19::chr2:232574974..232574995,-	p@chr2:232574974..232574995 -
Hg19::chr2:27435537..27435561,-	p7@SLC5A6
Hg19::chr2:27435611..27435624,-	p8@SLC5A6
Hg19::chr2:27435634..27435665,-	p6@SLC5A6
Hg19::chr2:86790191..86790209,+	p@chr2:86790191..86790209 +
Hg19::chr3:107810152..107810193,+	p@chr3:107810152..107810193 +
Hg19::chr3:13522103..13522125,-	p@chr3:13522103..13522125 -
Hg19::chr3:135914615..135914701,-	p3@MSL2
Hg19::chr3:14693622..14693632,-	p@chr3:14693622..14693632 -
Hg19::chr3:179041570..179041596,-	p@chr3:179041570..179041596 -
Hg19::chr3:179041606..179041620,-	p@chr3:179041606..179041620 -
Hg19::chr3:179041625..179041643,-	p@chr3:179041625..179041643 -
Hg19::chr3:23986876..23986885,+	p4@NR1D2
Hg19::chr3:71114290..71114305,+	p@chr3:71114290..71114305 +
Hg19::chr3:71115673..71115676,+	p@chr3:71115673..71115676 +
Hg19::chr4:149363856..149363872,+	p@chr4:149363856..149363872 +
Hg19::chr4:149364278..149364307,-	p@chr4:149364278..149364307 -
Hg19::chr4:26862558..26862576,+	p1@STIM2
Hg19::chr4:26863338..26863342,+	p@chr4:26863338..26863342 +
Hg19::chr4:76598867..76598882,+	p@chr4:76598867..76598882 +
Hg19::chr4:78783782..78783819,-	p@chr4:78783782..78783819 -
Hg19::chr5:179248528..179248568,-	p@chr5:179248528..179248568 -
Hg19::chr5:32312391..32312420,+	p@chr5:32312391..32312420 +
Hg19::chr5:34839130..34839157,-	p@chr5:34839130..34839157 -
Hg19::chr5:54603850..54603853,+	p5@SKIV2L2
Hg19::chr5:98265261..98265280,-	p@chr5:98265261..98265280 -
Hg19::chr6:109762344..109762356,-	p5@PPIL6
Hg19::chr6:119216251..119216300,-	p@chr6:119216251..119216300 -
Hg19::chr6:136610575..136610598,+	p@chr6:136610575..136610598 +
Hg19::chr6:159239993..159240009,+	p@chr6:159239993..159240009 +
Hg19::chr6:159290473..159290489,-	p@chr6:159290473..159290489 -
Hg19::chr6:159290503..159290512,-	p@chr6:159290503..159290512 -
Hg19::chr6:26285546..26285558,+	p@chr6:26285546..26285558 +
Hg19::chr6:28048860..28048889,-	p2@uc003nkf.2
Hg19::chr6:292408..292424,-	p@chr6:292408..292424 -
Hg19::chr6:32941036..32941050,-	p@chr6:32941036..32941050 -
Hg19::chr6:4021464..4021476,+	p6@PRPF4B
Hg19::chr6:7389966..7389993,-	p1@CAGE1
Hg19::chr6:87864744..87864763,+	p@chr6:87864744..87864763 +
Hg19::chr7:108209925..108209941,-	p2@THAP5
Hg19::chr7:130792816..130792827,-	p2@ENST00000423414
Hg19::chr7:140714541..140714552,+	p@chr7:140714541..140714552 +
Hg19::chr7:2550533..2550560,-	p@chr7:2550533..2550560 -
Hg19::chr7:35840534..35840564,-	p2@ENST00000424194
Hg19::chr8:104427080..104427102,+	p3@DCAF13
Hg19::chr8:81398511..81398523,+	p8@ZBTB10
Hg19::chr8:81398538..81398549,+	p14@ZBTB10
Hg19::chr8:81398552..81398563,+	p13@ZBTB10
Hg19::chr9:102583633..102583644,+	p8@NR4A3
Hg19::chr9:102669358..102669378,-	p1@LOC441461
Hg19::chr9:132769827..132769840,-	p@chr9:132769827..132769840 -
Hg19::chrX:110924483..110924500,+	p2@ALG13
Hg19::chrX:17755245..17755252,+	p6@SCML1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0043231	intracellular membrane-bound organelle	0.0226705607721863
GO:0043227	membrane-bound organelle	0.0226705607721863
GO:0032235	negative regulation of calcium ion transport via store-operated calcium channel	0.0400800066572294
GO:0004577	N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity	0.0400800066572294
GO:0016070	RNA metabolic process	0.0400800066572294
GO:0005634	nucleus	0.0460791453004554
GO:0032234	regulation of calcium ion transport via store-operated calcium channel	0.0460791453004554
GO:0008523	sodium-dependent multivitamin transmembrane transporter activity	0.0460791453004554
GO:0043169	cation binding	0.0495674418916741

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
leukocyte	2.66e-53	140
hematopoietic stem cell	4.78e-48	172
angioblastic mesenchymal cell	4.78e-48	172
hematopoietic cell	5.85e-44	182
hematopoietic oligopotent progenitor cell	1.08e-43	165
hematopoietic multipotent progenitor cell	1.08e-43	165
hematopoietic lineage restricted progenitor cell	6.31e-42	124
nongranular leukocyte	2.01e-41	119
lymphocyte	4.62e-25	53
common lymphoid progenitor	4.62e-25	53
lymphoid lineage restricted progenitor cell	7.34e-25	52
CD14-positive, CD16-negative classical monocyte	1.89e-21	42
classical monocyte	4.03e-21	45
myeloid leukocyte	5.20e-21	76
myeloid cell	4.18e-19	112
common myeloid progenitor	4.18e-19	112
granulocyte monocyte progenitor cell	2.90e-18	71
myeloid lineage restricted progenitor cell	3.14e-16	70
macrophage dendritic cell progenitor	5.99e-16	65
monopoietic cell	6.41e-15	63
monocyte	6.41e-15	63
monoblast	6.41e-15	63
promonocyte	6.41e-15	63
T cell	4.75e-12	25
pro-T cell	4.75e-12	25
lymphocyte of B lineage	5.24e-12	24
pro-B cell	5.24e-12	24
mature alpha-beta T cell	5.32e-11	18
alpha-beta T cell	5.32e-11	18
immature T cell	5.32e-11	18
mature T cell	5.32e-11	18
immature alpha-beta T cell	5.32e-11	18
B cell	8.73e-09	14
CD8-positive, alpha-beta T cell	5.79e-07	11

Uber Anatomy

Ontology term	p-value	n
hematopoietic system	3.65e-22	102
blood island	3.65e-22	102
hemolymphoid system	9.22e-20	112
bone marrow	8.94e-15	80
bone element	1.06e-13	86
immune system	6.29e-12	115
adult organism	1.50e-11	115
skeletal element	3.51e-08	101
skeletal system	3.51e-08	101
blood	9.74e-07	15
haemolymphatic fluid	9.74e-07	15
organism substance	9.74e-07	15

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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