Coexpression cluster:C2109

Full id: C2109_spleen_uterus_iPS_thyroid_diaphragm_bile_adipose

Phase1 CAGE Peaks

Hg19::chr11:128457446..128457461,-	p4@ETS1
Hg19::chr11:128457478..128457485,-	p26@ETS1
Hg19::chr11:128457492..128457506,-	p6@ETS1
Hg19::chr1:159172206..159172217,-	p3@LOC100131825

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0045648	positive regulation of erythrocyte differentiation	0.00803602967149417
GO:0045646	regulation of erythrocyte differentiation	0.00803602967149417
GO:0045639	positive regulation of myeloid cell differentiation	0.00803602967149417
GO:0030218	erythrocyte differentiation	0.0126103850229601
GO:0045637	regulation of myeloid cell differentiation	0.0126103850229601
GO:0045597	positive regulation of cell differentiation	0.0145266690215472
GO:0051094	positive regulation of developmental process	0.0178492582126457
GO:0030099	myeloid cell differentiation	0.0178492582126457
GO:0045595	regulation of cell differentiation	0.0281261038502296
GO:0030097	hemopoiesis	0.0281261038502296
GO:0048534	hemopoietic or lymphoid organ development	0.0281261038502296
GO:0002520	immune system development	0.0281261038502296
GO:0008285	negative regulation of cell proliferation	0.031261038502296
GO:0050793	regulation of developmental process	0.031261038502296

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.