Coexpression cluster:C1580

Full id: C1580_acute_Neutrophils_Mallassezderived_migratory_Smooth_Preadipocyte_small

Phase1 CAGE Peaks

Hg19::chr10:44101729..44101736,-	p1@CAP1P2
Hg19::chr1:40506327..40506338,+	p5@CAP1
Hg19::chr1:40506344..40506355,+	p3@CAP1
Hg19::chr1:40506371..40506382,+	p2@CAP1
Hg19::chr1:40506393..40506453,+	p1@CAP1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007190	adenylate cyclase activation	0.00508261705718434
GO:0031281	positive regulation of cyclase activity	0.00508261705718434
GO:0045762	positive regulation of adenylate cyclase activity	0.00508261705718434
GO:0051349	positive regulation of lyase activity	0.00508261705718434
GO:0007163	establishment and/or maintenance of cell polarity	0.00508261705718434
GO:0007189	G-protein signaling, adenylate cyclase activating pathway	0.00508261705718434
GO:0045761	regulation of adenylate cyclase activity	0.00508261705718434
GO:0031279	regulation of cyclase activity	0.00508261705718434
GO:0051339	regulation of lyase activity	0.00508261705718434
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger	0.00861404579172152
GO:0019933	cAMP-mediated signaling	0.00861404579172152
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	0.010221087049063
GO:0019935	cyclic-nucleotide-mediated signaling	0.010221087049063
GO:0043085	positive regulation of catalytic activity	0.0194591624475058
GO:0019932	second-messenger-mediated signaling	0.0194591624475058
GO:0003779	actin binding	0.0289225113492157
GO:0032989	cellular structure morphogenesis	0.0289225113492157
GO:0000902	cell morphogenesis	0.0289225113492157
GO:0008092	cytoskeletal protein binding	0.03294624985282
GO:0050790	regulation of catalytic activity	0.03294624985282
GO:0065009	regulation of a molecular function	0.0339611230639136
GO:0007010	cytoskeleton organization and biogenesis	0.0339611230639136
GO:0009653	anatomical structure morphogenesis	0.0495791930950809

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.