UBERON:0002523: Difference between revisions
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|located_in= | |located_in= | ||
|name=tunica intima | |name=tunica intima | ||
|namespace= | |namespace=FANTOM | ||
|obo_creation_date= | |obo_creation_date= | ||
|part_of= | |part_of= | ||
Latest revision as of 17:33, 12 September 2014
| Name: | tunica intima | ||
|---|---|---|---|
| Namespace: | FANTOM | ||
| Definition: | "The tunica intima (or just intima) is the innermost layer of an artery or vein. It is made up of one layer of endothelial cells and is supported by an internal elastic lamina. The endothelial cells are in direct contact with the blood flow. The inner coat (tunica intima) can be separated from the middle by a little maceration, or it may be stripped off in small pieces; but, on account of its friability, it cannot be separated as a complete membrane. It is a fine, transparent, colorless structure which is highly elastic, and, after death, is commonly corrugated into longitudinal wrinkles. The inner coat consists of: A layer of pavement endothelium, the cells of which are polygonal, oval, or fusiform, and have very distinct round or oval nuclei. This endothelium is brought into view most distinctly by staining with silver nitrate. A subendothelial layer, consisting of delicate connective tissue with branched cells lying in the interspaces of the tissue; in arteries of less than 2 mm. in diameter the subendothelial layer consists of a single stratum of stellate cells, and the connective tissue is only largely developed in vessels of a considerable size. An elastic or fenestrated layer, which consists of a membrane containing a net-work of elastic fibers, having principally a longitudinal direction, and in which, under the microscope, small elongated apertures or perforations may be seen, giving it a fenestrated appearance. It was therefore called by Henle the fenestrated membrane. This membrane forms the chief thickness of the inner coat, and can be separated into several layers, some of which present the appearance of a network of longitudinal elastic fibers, and others a more membranous character, marked by pale lines having a longitudinal direction. In minute arteries the fenestrated membrane is a very thin layer; but in the larger arteries, and especially in the aorta, it has a very considerable thickness. [WP,unvetted]." [Wikipedia:Tunica_intima] | ||
| Xrefs: |
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| Synonyms: | "tunica intima vasorum" RELATED [BTO:0002012] | ||
| Comments: | todo - check BTO | ||
| Alt_id: | UBERON:MA_0002861-FMA_55589 | ||
| Subset: | uberon_slim |
Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data
Parents
| is_a: | UBERON:0004797(blood vessel layer) |
|---|
Children
| is a: | UBERON:0002165 (endocardium) |
|---|
Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology
Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0002523 (tunica intima), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data
| P-value | FFCP | Short description |
|---|---|---|
| 5.41e-147 | FFCP PHASE1:Hg19::chr7:25815812..25815822,-#_f6fab473274db3db7b78677e847f575b | p@chr7:25815812..25815822, - |
| 5.41e-147 | FFCP PHASE2:Hg19::chr7:25815812..25815822,-#_f6fab473274db3db7b78677e847f575b | p@chr7:25815812..25815822, - |
| 8.98e-131 | FFCP PHASE1:Hg19::chr12:3373147..3373149,-#_528106190cadde447a792a906e944976 | p@chr12:3373147..3373149, - |
| 8.98e-131 | FFCP PHASE2:Hg19::chr12:3373147..3373149,-#_528106190cadde447a792a906e944976 | p@chr12:3373147..3373149, - |
| 7.78e-118 | FFCP PHASE1:Hg19::chr1:20355975..20355980,-#_6c782d3b57bcdd325c6b4defcacc5bf4 | p@chr1:20355975..20355980, - |
| 7.78e-118 | FFCP PHASE2:Hg19::chr1:20355975..20355980,-#_6c782d3b57bcdd325c6b4defcacc5bf4 | p@chr1:20355975..20355980, - |
| 5.69e-99 | FFCP PHASE2:Hg19::chr1:237331032..237331036,+#_a6b32bf20bc163c1cac382c9d4c2a847 | p@chr1:237331032..237331036, + |
| 5.69e-99 | FFCP PHASE1:Hg19::chr1:237331032..237331036,+#_a6b32bf20bc163c1cac382c9d4c2a847 | p@chr1:237331032..237331036, + |
| 1.52e-87 | FFCP PHASE1:Hg19::chr6:6739548..6739577,-#_b0ea8010f49274d7cc69650ceda4b608 | p@chr6:6739548..6739577, - |
| 1.52e-87 | FFCP PHASE1:Hg19::chr1:11907265..11907271,-#_b0ea8010f49274d7cc69650ceda4b608 | p9@NPPA |
| 1.52e-87 | FFCP PHASE1:Hg19::chr2:18116344..18116353,+#_b0ea8010f49274d7cc69650ceda4b608 | p@chr2:18116344..18116353, + |
| 1.52e-87 | FFCP PHASE2:Hg19::chr6:6739548..6739577,-#_b0ea8010f49274d7cc69650ceda4b608 | p@chr6:6739548..6739577, - |
| 1.52e-87 | FFCP PHASE2:Hg19::chr2:18116344..18116353,+#_b0ea8010f49274d7cc69650ceda4b608 | p@chr2:18116344..18116353, + |
| 1.52e-87 | FFCP PHASE2:Hg19::chr1:11907265..11907271,-#_b0ea8010f49274d7cc69650ceda4b608 | p9@NPPA |
| 7.21e-85 | FFCP PHASE2:Hg19::chrX:112324334..112324339,-#_7fd44b8e70160439dde61816838139a4 | p@chrX:112324334..112324339, - |
| 7.21e-85 | FFCP PHASE1:Hg19::chrX:112324334..112324339,-#_7fd44b8e70160439dde61816838139a4 | p@chrX:112324334..112324339, - |
| 1.71e-84 | FFCP PHASE1:Hg19::chr2:220491902..220491915,+#_b669dafa8c89ccc356469dcf429eb27e | p11@SLC4A3 |
| 1.71e-84 | FFCP PHASE2:Hg19::chr2:220491902..220491915,+#_b669dafa8c89ccc356469dcf429eb27e | p11@SLC4A3 |
| 2.27e-84 | FFCP PHASE2:Hg19::chr2:179533457..179533461,-#_b14098c1c3564d770b9e8ac2ad464ae6 | p@chr2:179533457..179533461, - |
| 2.27e-84 | FFCP PHASE1:Hg19::chr2:179533457..179533461,-#_b14098c1c3564d770b9e8ac2ad464ae6 | p@chr2:179533457..179533461, - |
| 3.03e-84 | FFCP PHASE1:Hg19::chr2:179398102..179398109,-#_6dde09a1db4a0e9aafa21718d39f7948 | p@chr2:179398102..179398109, - |
| 3.03e-84 | FFCP PHASE2:Hg19::chr2:179398102..179398109,-#_6dde09a1db4a0e9aafa21718d39f7948 | p@chr2:179398102..179398109, - |
| 7.81e-75 | FFCP PHASE2:Hg19::chr5:123739302..123739319,-#_96d9e3511fdf0c59fa0047c4b5828588 | p@chr5:123739302..123739319, - |
| 7.81e-75 | FFCP PHASE1:Hg19::chr5:123739302..123739319,-#_96d9e3511fdf0c59fa0047c4b5828588 | p@chr5:123739302..123739319, - |
| 1.01e-74 | FFCP PHASE1:Hg19::chr18:64271475..64271484,-#_4f2788d91c2659a96935e2e0b6cc0c20 | p6@CDH19 |
| 1.01e-74 | FFCP PHASE2:Hg19::chr18:64271475..64271484,-#_4f2788d91c2659a96935e2e0b6cc0c20 | p6@CDH19 |
| 1.29e-74 | FFCP PHASE2:Hg19::chr7:35286774..35286778,-#_df2b14278dfc10087b5b82847e6226df | p@chr7:35286774..35286778, - |
| 1.29e-74 | FFCP PHASE1:Hg19::chr7:35286774..35286778,-#_df2b14278dfc10087b5b82847e6226df | p@chr7:35286774..35286778, - |
| 1.66e-74 | FFCP PHASE2:Hg19::chr6:129355052..129355056,+#_5e6e9da1b49e04045c339d2a3196c3cf | p@chr6:129355052..129355056, + |
| 1.66e-74 | FFCP PHASE1:Hg19::chr6:129355052..129355056,+#_5e6e9da1b49e04045c339d2a3196c3cf | p@chr6:129355052..129355056, + |
| 2.75e-74 | FFCP PHASE2:Hg19::chr3:16940540..16940554,+#_b0896d9af2288452d93720a88aa02ffe | p@chr3:16940540..16940554, + |
| 2.75e-74 | FFCP PHASE1:Hg19::chr3:16940540..16940554,+#_b0896d9af2288452d93720a88aa02ffe | p@chr3:16940540..16940554, + |
| 3.54e-74 | FFCP PHASE1:Hg19::chr20:33565465..33565475,+#_76f2e020f55d86c59948e19239cd86f3 | p9@MYH7B |
| 3.54e-74 | FFCP PHASE2:Hg19::chr19:55661803..55661807,-#_76f2e020f55d86c59948e19239cd86f3 | p@chr19:55661803..55661807, - |
| 3.54e-74 | FFCP PHASE1:Hg19::chr19:55661803..55661807,-#_76f2e020f55d86c59948e19239cd86f3 | p@chr19:55661803..55661807, - |
| 3.54e-74 | FFCP PHASE2:Hg19::chr3:131523446..131523459,-#_76f2e020f55d86c59948e19239cd86f3 | p@chr3:131523446..131523459, - |
| 3.54e-74 | FFCP PHASE2:Hg19::chr20:33565465..33565475,+#_76f2e020f55d86c59948e19239cd86f3 | p9@MYH7B |
| 3.54e-74 | FFCP PHASE2:Hg19::chr1:201328779..201328797,-#_76f2e020f55d86c59948e19239cd86f3 | p@chr1:201328779..201328797, - |
| 3.54e-74 | FFCP PHASE1:Hg19::chr1:201328779..201328797,-#_76f2e020f55d86c59948e19239cd86f3 | p@chr1:201328779..201328797, - |
| 3.54e-74 | FFCP PHASE1:Hg19::chr3:131523446..131523459,-#_76f2e020f55d86c59948e19239cd86f3 | p@chr3:131523446..131523459, - |
| 5.84e-74 | FFCP PHASE1:Hg19::chr6:36812121..36812130,-#_ea18713b354928ea056f927cc9c3467c | p@chr6:36812121..36812130, - |
| 5.84e-74 | FFCP PHASE2:Hg19::chr6:36812121..36812130,-#_ea18713b354928ea056f927cc9c3467c | p@chr6:36812121..36812130, - |
| 7.51e-74 | FFCP PHASE2:Hg19::chr14:105939326..105939337,+#_648e750f3494e2f5351b2eeed34a1c11 | p16@CRIP2 |
| 7.51e-74 | FFCP PHASE1:Hg19::chr14:105939326..105939337,+#_648e750f3494e2f5351b2eeed34a1c11 | p16@CRIP2 |
| 9.64e-74 | FFCP PHASE1:Hg19::chr1:206838422..206838456,+#_cfe258eb19b86dc345e2792c7c66d5e2 | p@chr1:206838422..206838456, + |
| 9.64e-74 | FFCP PHASE2:Hg19::chr1:206838422..206838456,+#_cfe258eb19b86dc345e2792c7c66d5e2 | p@chr1:206838422..206838456, + |
| 1.24e-73 | FFCP PHASE2:Hg19::chr1:231983543..231983554,-#_f5ec424e8966253731ddee12c29dfc11 | p@chr1:231983543..231983554, - |
| 1.24e-73 | FFCP PHASE1:Hg19::chr1:231983543..231983554,-#_f5ec424e8966253731ddee12c29dfc11 | p@chr1:231983543..231983554, - |
| 1.54e-66 | FFCP PHASE2:Hg19::chr1:201328328..201328343,-#_f905db0c98eedf6647f220ca3ea4b519 | p@chr1:201328328..201328343, - |
| 1.54e-66 | FFCP PHASE1:Hg19::chr1:201328328..201328343,-#_f905db0c98eedf6647f220ca3ea4b519 | p@chr1:201328328..201328343, - |
| 1.71e-66 | FFCP PHASE1:Hg19::chr11:47367243..47367257,-#_9caa4a1d9024fcb04de4fcd3eeb36959 | p@chr11:47367243..47367257, - |
| 1.71e-66 | FFCP PHASE2:Hg19::chr11:47367243..47367257,-#_9caa4a1d9024fcb04de4fcd3eeb36959 | p@chr11:47367243..47367257, - |
| 1.71e-66 | FFCP PHASE2:Hg19::chr1:237214095..237214115,+#_9caa4a1d9024fcb04de4fcd3eeb36959 | p@chr1:237214095..237214115, + |
| 1.71e-66 | FFCP PHASE1:Hg19::chr1:237214095..237214115,+#_9caa4a1d9024fcb04de4fcd3eeb36959 | p@chr1:237214095..237214115, + |
| 2.39e-66 | FFCP PHASE2:Hg19::chr10:92678409..92678410,-#_f6d2759796065c56aa05683d4ebaa7ae | p@chr10:92678409..92678410, - |
| 2.39e-66 | FFCP PHASE1:Hg19::chr5:99390735..99390743,-#_f6d2759796065c56aa05683d4ebaa7ae | p@chr5:99390735..99390743, - |
| 2.39e-66 | FFCP PHASE1:Hg19::chr10:92678409..92678410,-#_f6d2759796065c56aa05683d4ebaa7ae | p@chr10:92678409..92678410, - |
| 2.39e-66 | FFCP PHASE2:Hg19::chr5:99390735..99390743,-#_f6d2759796065c56aa05683d4ebaa7ae | p@chr5:99390735..99390743, - |
| 2.39e-66 | FFCP PHASE2:Hg19::chr15:86272097..86272099,+#_f6d2759796065c56aa05683d4ebaa7ae | p@chr15:86272097..86272099, + |
| 2.39e-66 | FFCP PHASE1:Hg19::chr15:86272097..86272099,+#_f6d2759796065c56aa05683d4ebaa7ae | p@chr15:86272097..86272099, + |
| 2.4e-66 | FFCP PHASE2:Hg19::chr12:114886577..114886589,-#_b79e848dd1d633f6561803ee42662c0d | p@chr12:114886577..114886589, - |
| 2.4e-66 | FFCP PHASE2:Hg19::chr2:159976509..159976519,+#_b79e848dd1d633f6561803ee42662c0d | p@chr2:159976509..159976519, + |
| 2.4e-66 | FFCP PHASE1:Hg19::chr12:4735761..4735787,-#_b79e848dd1d633f6561803ee42662c0d | p@chr12:4735761..4735787, - |
| 2.4e-66 | FFCP PHASE2:Hg19::chr12:4735761..4735787,-#_b79e848dd1d633f6561803ee42662c0d | p@chr12:4735761..4735787, - |
| 2.4e-66 | FFCP PHASE1:Hg19::chr2:159976509..159976519,+#_b79e848dd1d633f6561803ee42662c0d | p@chr2:159976509..159976519, + |
| 2.4e-66 | FFCP PHASE2:Hg19::chr1:237996521..237996532,+#_b79e848dd1d633f6561803ee42662c0d | p@chr1:237996521..237996532, + |
| 2.4e-66 | FFCP PHASE1:Hg19::chr12:114886577..114886589,-#_b79e848dd1d633f6561803ee42662c0d | p@chr12:114886577..114886589, - |
| 2.4e-66 | FFCP PHASE1:Hg19::chr1:237996521..237996532,+#_b79e848dd1d633f6561803ee42662c0d | p@chr1:237996521..237996532, + |
| 2.41e-66 | FFCP PHASE2:Hg19::chr1:237207955..237207959,+#_e518dd1239e481b9b0ad1a98ae9c9aa5 | p@chr1:237207955..237207959, + |
| 2.41e-66 | FFCP PHASE1:Hg19::chr2:40480968..40480972,-#_e518dd1239e481b9b0ad1a98ae9c9aa5 | p@chr2:40480968..40480972, - |
| 2.41e-66 | FFCP PHASE1:Hg19::chr1:237207955..237207959,+#_e518dd1239e481b9b0ad1a98ae9c9aa5 | p@chr1:237207955..237207959, + |
| 2.41e-66 | FFCP PHASE2:Hg19::chr2:40480968..40480972,-#_e518dd1239e481b9b0ad1a98ae9c9aa5 | p@chr2:40480968..40480972, - |
| 3.01e-66 | FFCP PHASE2:Hg19::chr4:62999501..62999517,+#_f02d43d55d444a98e7dfc7385040ef98 | p@chr4:62999501..62999517, + |
| 3.01e-66 | FFCP PHASE1:Hg19::chr4:62999501..62999517,+#_f02d43d55d444a98e7dfc7385040ef98 | p@chr4:62999501..62999517, + |
| 3.35e-66 | FFCP PHASE2:Hg19::chr7:35253487..35253489,-#_4836ed21a32f81e59839fd6d4142a024 | p@chr7:35253487..35253489, - |
| 3.35e-66 | FFCP PHASE2:Hg19::chr1:11905830..11905839,-#_4836ed21a32f81e59839fd6d4142a024 | p@chr1:11905830..11905839, - |
| 3.35e-66 | FFCP PHASE2:Hg19::chr9:38650254..38650266,+#_4836ed21a32f81e59839fd6d4142a024 | p@chr9:38650254..38650266, + |
| 3.35e-66 | FFCP PHASE1:Hg19::chr7:44179972..44179982,-#_4836ed21a32f81e59839fd6d4142a024 | p2@MYL7 |
| 3.35e-66 | FFCP PHASE2:Hg19::chr7:44178491..44178498,-#_4836ed21a32f81e59839fd6d4142a024 | p@chr7:44178491..44178498, - |
| 3.35e-66 | FFCP PHASE1:Hg19::chr1:11905830..11905839,-#_4836ed21a32f81e59839fd6d4142a024 | p@chr1:11905830..11905839, - |
| 3.35e-66 | FFCP PHASE1:Hg19::chr5:65736120..65736128,-#_4836ed21a32f81e59839fd6d4142a024 | p@chr5:65736120..65736128, - |
| 3.35e-66 | FFCP PHASE1:Hg19::chr7:35253487..35253489,-#_4836ed21a32f81e59839fd6d4142a024 | p@chr7:35253487..35253489, - |
| 3.35e-66 | FFCP PHASE2:Hg19::chr7:44179972..44179982,-#_4836ed21a32f81e59839fd6d4142a024 | p2@MYL7 |
| 3.35e-66 | FFCP PHASE1:Hg19::chr9:38650254..38650266,+#_4836ed21a32f81e59839fd6d4142a024 | p@chr9:38650254..38650266, + |
| 3.35e-66 | FFCP PHASE2:Hg19::chr5:65736120..65736128,-#_4836ed21a32f81e59839fd6d4142a024 | p@chr5:65736120..65736128, - |
| 3.35e-66 | FFCP PHASE1:Hg19::chr7:44178491..44178498,-#_4836ed21a32f81e59839fd6d4142a024 | p@chr7:44178491..44178498, - |
| 4.68e-66 | FFCP PHASE1:Hg19::chr7:44180643..44180652,-#_249ff41200b3af8fe79e238a420c1555 | p3@MYL7 |
| 4.68e-66 | FFCP PHASE1:Hg19::chr10:112524543..112524547,+#_249ff41200b3af8fe79e238a420c1555 | p@chr10:112524543..112524547, + |
| 4.68e-66 | FFCP PHASE2:Hg19::chr10:112524543..112524547,+#_249ff41200b3af8fe79e238a420c1555 | p@chr10:112524543..112524547, + |
| 4.68e-66 | FFCP PHASE2:Hg19::chr7:44180643..44180652,-#_249ff41200b3af8fe79e238a420c1555 | p3@MYL7 |
| 5.88e-66 | FFCP PHASE2:Hg19::chr6:36812225..36812238,-#_bf3c08d74ecb1293eae0f20921407f97 | p@chr6:36812225..36812238, - |
| 5.88e-66 | FFCP PHASE1:Hg19::chr6:36812225..36812238,-#_bf3c08d74ecb1293eae0f20921407f97 | p@chr6:36812225..36812238, - |
| 6.53e-66 | FFCP PHASE2:Hg19::chr2:168104544..168104551,+#_4021f8481e82a7b7b8e489196a8f785f | p52@XIRP2 |
| 6.53e-66 | FFCP PHASE1:Hg19::chr4:62999459..62999462,+#_4021f8481e82a7b7b8e489196a8f785f | p@chr4:62999459..62999462, + |
| 6.53e-66 | FFCP PHASE2:Hg19::chr4:62999459..62999462,+#_4021f8481e82a7b7b8e489196a8f785f | p@chr4:62999459..62999462, + |
| 6.53e-66 | FFCP PHASE1:Hg19::chr2:168104544..168104551,+#_4021f8481e82a7b7b8e489196a8f785f | p52@XIRP2 |
| 1.15e-65 | FFCP PHASE1:Hg19::chrX:121555838..121555874,+#_ff48457c81f4049bade5bfcc9d515635 | p@chrX:121555838..121555874, + |
| 1.15e-65 | FFCP PHASE2:Hg19::chr7:123302841..123302854,+#_ff48457c81f4049bade5bfcc9d515635 | p@chr7:123302841..123302854, + |
| 1.15e-65 | FFCP PHASE1:Hg19::chr10:127569398..127569410,-#_ff48457c81f4049bade5bfcc9d515635 | p5@DHX32 |
| 1.15e-65 | FFCP PHASE2:Hg19::chr10:127569398..127569410,-#_ff48457c81f4049bade5bfcc9d515635 | p5@DHX32 |
