CL:0000129: Difference between revisions
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|located_in= | |located_in= | ||
|name=microglial cell | |name=microglial cell | ||
|namespace= | |namespace=FANTOM | ||
|obo_creation_date= | |obo_creation_date= | ||
|part_of=UBERON:0001017 | |part_of=UBERON:0001017 | ||
Latest revision as of 16:30, 12 September 2014
| Name: | microglial cell | ||
|---|---|---|---|
| Namespace: | FANTOM | ||
| Definition: | "A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0721601464, MESH:D017628, PMID:11517395, PMID:12430718, PMID:14561199, PMID:14612429, PMID:16177057, PMID:19461673, PMID:2089275] | ||
| Xrefs: |
| ||
| Synonyms: |
"brain macrophage" BROAD [] "brain-resident macrophage" EXACT [] "hortega cells" EXACT [1] "MF.microglia.CNS" RELATED [] "microglia" EXACT [] "microgliocyte" EXACT [2] | ||
| Comments: | Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD19-negative, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive. |
Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data
Parents
| is_a: | CL:0000243(glial cell (sensu Vertebrata)),CL:0000878(central nervous system macrophage) |
|---|---|
| develops_from: | CL:0002453(oligodendrocyte precursor cell) |
| part_of: | UBERON:0001017(central nervous system) |
Children
| is a: | FF:0000100 (microglial cell) |
|---|---|
| derives from: | FF:0000113 (mouse microglial cell sample) |
Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.
Human (Homo sapiens)
- 11501-119F7
- 11641-122D3 (Mouse Microglia, donor3)
- 11662-122F6
- 11718-123C8 (Mouse Microglia, donor1)
- 11736-123E8 (Mouse Microglia, donor2)
Mouse (Mus musculus)
- 11501-119F7
- 11641-122D3 (Mouse Microglia, donor3)
- 11662-122F6
- 11718-123C8 (Mouse Microglia, donor1)
- 11736-123E8 (Mouse Microglia, donor2)
Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000129 (microglial cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data
| P-value | FFCP | Short description |
|---|---|---|
| 1.87e-86 | FFCP PHASE2:Mm9::chr12:112646729..112646768,+#_830011477e36205b441e1057fa5cfac0 | p@chr12:112646729..112646768, + |
| 1.87e-86 | FFCP PHASE2:Mm9::chr8:113227136..113227143,+#_830011477e36205b441e1057fa5cfac0 | p@chr8:113227136..113227143, + |
| 1.87e-86 | FFCP PHASE1:Mm9::chr12:112646729..112646768,+#_830011477e36205b441e1057fa5cfac0 | p@chr12:112646729..112646768, + |
| 1.87e-86 | FFCP PHASE1:Mm9::chr8:113227136..113227143,+#_830011477e36205b441e1057fa5cfac0 | p@chr8:113227136..113227143, + |
| 1.68e-58 | FFCP PHASE1:Mm9::chr10:75403311..75403323,-#_28ea8393181c10719994f4a75930ce42 | p3@ENSMUST00000059658, p3@uc007fts.1 |
| 1.68e-58 | FFCP PHASE2:Mm9::chr10:75403311..75403323,-#_28ea8393181c10719994f4a75930ce42 | p3@ENSMUST00000059658, p3@uc007fts.1 |
| 1.66e-44 | FFCP PHASE2:Mm9::chr11:102749101..102749112,-#_d7d647ed8914ba0368313c83290ea8f2 | p@chr11:102749101..102749112, - |
| 1.66e-44 | FFCP PHASE2:Mm9::chr15:88808274..88808289,-#_d7d647ed8914ba0368313c83290ea8f2 | p@chr15:88808274..88808289, - |
| 1.66e-44 | FFCP PHASE1:Mm9::chr10:59862550..59862553,+#_d7d647ed8914ba0368313c83290ea8f2 | p3@Gm17455 |
| 1.66e-44 | FFCP PHASE1:Mm9::chr15:88808274..88808289,-#_d7d647ed8914ba0368313c83290ea8f2 | p@chr15:88808274..88808289, - |
| 1.66e-44 | FFCP PHASE1:Mm9::chr11:102749101..102749112,-#_d7d647ed8914ba0368313c83290ea8f2 | p@chr11:102749101..102749112, - |
| 1.66e-44 | FFCP PHASE2:Mm9::chr10:59862550..59862553,+#_d7d647ed8914ba0368313c83290ea8f2 | p3@Gm17455 |
| 2.75e-44 | FFCP PHASE1:Mm9::chr4:135525988..135526004,-#_789dc8a1cafa9b3433ad6ae1881dbe8b | p@chr4:135525988..135526004, - |
| 2.75e-44 | FFCP PHASE2:Mm9::chr4:135525988..135526004,-#_789dc8a1cafa9b3433ad6ae1881dbe8b | p@chr4:135525988..135526004, - |
| 4.55e-44 | FFCP PHASE2:Mm9::chr17:48934179..48934192,-#_c223dd1033647d17eb528d81bc0add21 | p@chr17:48934179..48934192, - |
| 4.55e-44 | FFCP PHASE1:Mm9::chr17:48934179..48934192,-#_c223dd1033647d17eb528d81bc0add21 | p@chr17:48934179..48934192, - |
| 7.52e-44 | FFCP PHASE2:Mm9::chr11:94506584..94506586,+#_5b9440d6aab0e4294ad2b8cdf5a9f300 | p@chr11:94506584..94506586, + |
| 7.52e-44 | FFCP PHASE1:Mm9::chr11:94506584..94506586,+#_5b9440d6aab0e4294ad2b8cdf5a9f300 | p@chr11:94506584..94506586, + |
| 4.23e-36 | FFCP PHASE1:Mm9::chr11:102749254..102749263,-#_84e5c698051da5e29039fbea880bf1a2 | p@chr11:102749254..102749263, - |
| 4.23e-36 | FFCP PHASE2:Mm9::chr11:102749254..102749263,-#_84e5c698051da5e29039fbea880bf1a2 | p@chr11:102749254..102749263, - |
| 2.13e-35 | FFCP PHASE2:Mm9::chr16:15895800..15895814,-#_597f78a11b1bcb98437d407aa61c274c | p@chr16:15895800..15895814, - |
| 2.13e-35 | FFCP PHASE1:Mm9::chr16:15895800..15895814,-#_597f78a11b1bcb98437d407aa61c274c | p@chr16:15895800..15895814, - |
| 4.75e-35 | FFCP PHASE2:Mm9::chr11:75244815..75244826,-#_a747405c4367765b2716e96e6c2870ca | p@chr11:75244815..75244826, - |
| 4.75e-35 | FFCP PHASE1:Mm9::chr11:75244815..75244826,-#_a747405c4367765b2716e96e6c2870ca | p@chr11:75244815..75244826, - |
| 1.73e-30 | FFCP PHASE2:Mm9::chr11:45567111..45567116,-#_15eeb93f8b2c3b8fd2ed55553b7b2e21 | p@chr11:45567111..45567116, - |
| 1.73e-30 | FFCP PHASE1:Mm9::chr11:45567111..45567116,-#_15eeb93f8b2c3b8fd2ed55553b7b2e21 | p@chr11:45567111..45567116, - |
| 3.41e-30 | FFCP PHASE2:Mm9::chr17:35822365..35822376,-#_ac5d173e60a8dd4e71f23e36522464a8 | p@chr17:35822365..35822376, - |
| 3.41e-30 | FFCP PHASE2:Mm9::chr9:103595089..103595100,-#_ac5d173e60a8dd4e71f23e36522464a8 | p4@Tmem108 |
| 3.41e-30 | FFCP PHASE1:Mm9::chr9:103595089..103595100,-#_ac5d173e60a8dd4e71f23e36522464a8 | p4@Tmem108 |
| 3.41e-30 | FFCP PHASE1:Mm9::chr17:35822365..35822376,-#_ac5d173e60a8dd4e71f23e36522464a8 | p@chr17:35822365..35822376, - |
| 4.77e-30 | FFCP PHASE1:Mm9::chr11:102754448..102754459,-#_d07d88075d714adae8b5a562bc7e142d | p@chr11:102754448..102754459, - |
| 4.77e-30 | FFCP PHASE2:Mm9::chr11:102754448..102754459,-#_d07d88075d714adae8b5a562bc7e142d | p@chr11:102754448..102754459, - |
| 6.69e-30 | FFCP PHASE1:Mm9::chr7:56865136..56865147,+#_2fdb027034483b4be917c37eb2f5673b | p@chr7:56865136..56865147, + |
| 6.69e-30 | FFCP PHASE2:Mm9::chr7:56865136..56865147,+#_2fdb027034483b4be917c37eb2f5673b | p@chr7:56865136..56865147, + |
| 1.31e-29 | FFCP PHASE1:Mm9::chr4:136452258..136452269,-#_7510679e9b1beeb9c5564a2fad398056 | p@chr4:136452258..136452269, - |
| 1.31e-29 | FFCP PHASE2:Mm9::chr4:136452258..136452269,-#_7510679e9b1beeb9c5564a2fad398056 | p@chr4:136452258..136452269, - |
| 1.78e-26 | FFCP PHASE1:Mm9::chr11:102754827..102754845,-#_cb16ab5f71908387d8318199614e5b94 | p@chr11:102754827..102754845, - |
| 1.78e-26 | FFCP PHASE2:Mm9::chr11:102754827..102754845,-#_cb16ab5f71908387d8318199614e5b94 | p@chr11:102754827..102754845, - |
| 2.38e-26 | FFCP PHASE1:Mm9::chr11:102750776..102750792,-#_40ff247d9f82cfbbdd1273d2e4299277 | p@chr11:102750776..102750792, - |
| 2.38e-26 | FFCP PHASE2:Mm9::chr11:102750776..102750792,-#_40ff247d9f82cfbbdd1273d2e4299277 | p@chr11:102750776..102750792, - |
| 4.27e-26 | FFCP PHASE1:Mm9::chr11:102807862..102807882,-#_92cb1c5120b11059ddf717e0dac5b08b | p4@C1ql1 |
| 4.27e-26 | FFCP PHASE2:Mm9::chr11:102807862..102807882,-#_92cb1c5120b11059ddf717e0dac5b08b | p4@C1ql1 |
| 7.61e-26 | FFCP PHASE1:Mm9::chr11:32036107..32036145,-#_36042962e11a2cb1dccb6c25798cf3bb | p@chr11:32036107..32036145, - |
| 7.61e-26 | FFCP PHASE2:Mm9::chr11:32036107..32036145,-#_36042962e11a2cb1dccb6c25798cf3bb | p@chr11:32036107..32036145, - |
| 1.02e-25 | FFCP PHASE2:Mm9::chr7:31844871..31844895,+#_a0bd3a20f343bfbf9ce9f59bc6268723 | p9@Lgi4 |
| 1.02e-25 | FFCP PHASE1:Mm9::chr7:31844871..31844895,+#_a0bd3a20f343bfbf9ce9f59bc6268723 | p9@Lgi4 |
| 1.35e-25 | FFCP PHASE1:Mm9::chr8:125951458..125951466,-#_5512d0cfe5fd816038f4b4cf5812cd17 | p@chr8:125951458..125951466, - |
| 1.35e-25 | FFCP PHASE2:Mm9::chr8:125951458..125951466,-#_5512d0cfe5fd816038f4b4cf5812cd17 | p@chr8:125951458..125951466, - |
| 1.35e-25 | FFCP PHASE2:Mm9::chr8:28132545..28132551,+#_5512d0cfe5fd816038f4b4cf5812cd17 | p@chr8:28132545..28132551, + |
| 1.35e-25 | FFCP PHASE2:Mm9::chr1:72873192..72873206,+#_5512d0cfe5fd816038f4b4cf5812cd17 | p@chr1:72873192..72873206, + |
| 1.35e-25 | FFCP PHASE1:Mm9::chr8:28132545..28132551,+#_5512d0cfe5fd816038f4b4cf5812cd17 | p@chr8:28132545..28132551, + |
| 1.35e-25 | FFCP PHASE1:Mm9::chr1:72873192..72873206,+#_5512d0cfe5fd816038f4b4cf5812cd17 | p@chr1:72873192..72873206, + |
| 1.8e-25 | FFCP PHASE2:Mm9::chr1:174128785..174128802,+#_e07a33bc9870f15df3e7295ff29219d3 | p@chr1:174128785..174128802, + |
| 1.8e-25 | FFCP PHASE1:Mm9::chr1:174128785..174128802,+#_e07a33bc9870f15df3e7295ff29219d3 | p@chr1:174128785..174128802, + |
| 1.8e-25 | FFCP PHASE2:Mm9::chr1:34754390..34754396,+#_e07a33bc9870f15df3e7295ff29219d3 | p@chr1:34754390..34754396, + |
| 1.8e-25 | FFCP PHASE1:Mm9::chr1:34754390..34754396,+#_e07a33bc9870f15df3e7295ff29219d3 | p@chr1:34754390..34754396, + |
| 3.19e-25 | FFCP PHASE1:Mm9::chr8:125952002..125952012,-#_0ae253533b8a3b95bec135e8925edee9 | p@chr8:125952002..125952012, - |
| 3.19e-25 | FFCP PHASE1:Mm9::chr8:125952310..125952320,+#_0ae253533b8a3b95bec135e8925edee9 | p@chr8:125952310..125952320, + |
| 3.19e-25 | FFCP PHASE1:Mm9::chr8:125956332..125956339,-#_0ae253533b8a3b95bec135e8925edee9 | p@chr8:125956332..125956339, - |
| 3.19e-25 | FFCP PHASE1:Mm9::chr8:125951545..125951559,-#_0ae253533b8a3b95bec135e8925edee9 | p@chr8:125951545..125951559, - |
| 3.19e-25 | FFCP PHASE2:Mm9::chr8:125952002..125952012,-#_0ae253533b8a3b95bec135e8925edee9 | p@chr8:125952002..125952012, - |
| 3.19e-25 | FFCP PHASE2:Mm9::chr8:125952310..125952320,+#_0ae253533b8a3b95bec135e8925edee9 | p@chr8:125952310..125952320, + |
| 3.19e-25 | FFCP PHASE2:Mm9::chr8:125956332..125956339,-#_0ae253533b8a3b95bec135e8925edee9 | p@chr8:125956332..125956339, - |
| 3.19e-25 | FFCP PHASE2:Mm9::chr8:125951545..125951559,-#_0ae253533b8a3b95bec135e8925edee9 | p@chr8:125951545..125951559, - |
| 5.1e-23 | FFCP PHASE2:Mm9::chr11:69414608..69414617,-#_3c22ef516fd677815646f6cf8d91a1a9 | p@chr11:69414608..69414617, - |
| 5.1e-23 | FFCP PHASE1:Mm9::chr11:69414608..69414617,-#_3c22ef516fd677815646f6cf8d91a1a9 | p@chr11:69414608..69414617, - |
| 8.47e-23 | FFCP PHASE2:Mm9::chr3:87067576..87067584,-#_98615a4c24dcb3f5a76f622bddd00996 | p3@Fcrls |
| 8.47e-23 | FFCP PHASE1:Mm9::chr3:87067625..87067636,-#_98615a4c24dcb3f5a76f622bddd00996 | p2@Fcrls |
| 8.47e-23 | FFCP PHASE1:Mm9::chr4:136452194..136452198,-#_98615a4c24dcb3f5a76f622bddd00996 | p@chr4:136452194..136452198, - |
| 8.47e-23 | FFCP PHASE2:Mm9::chr4:136452194..136452198,-#_98615a4c24dcb3f5a76f622bddd00996 | p@chr4:136452194..136452198, - |
| 8.47e-23 | FFCP PHASE1:Mm9::chr4:136436677..136436688,-#_98615a4c24dcb3f5a76f622bddd00996 | p@chr4:136436677..136436688, - |
| 8.47e-23 | FFCP PHASE2:Mm9::chr4:136436677..136436688,-#_98615a4c24dcb3f5a76f622bddd00996 | p@chr4:136436677..136436688, - |
| 8.47e-23 | FFCP PHASE2:Mm9::chr3:87067625..87067636,-#_98615a4c24dcb3f5a76f622bddd00996 | p2@Fcrls |
| 8.47e-23 | FFCP PHASE1:Mm9::chr3:87067576..87067584,-#_98615a4c24dcb3f5a76f622bddd00996 | p3@Fcrls |
| 9.5e-23 | FFCP PHASE2:Mm9::chr9:106363021..106363029,+#_9f0301db9f49f031e6f463c0207de1d8 | p11@Pcbp4 |
| 9.5e-23 | FFCP PHASE2:Mm9::chr5:123689685..123689727,+#_9f0301db9f49f031e6f463c0207de1d8 | p@chr5:123689685..123689727, + |
| 9.5e-23 | FFCP PHASE2:Mm9::chr19:6497758..6497764,+#_9f0301db9f49f031e6f463c0207de1d8 | p17@Nrxn2 |
| 9.5e-23 | FFCP PHASE2:Mm9::chr17:24856898..24856901,+#_9f0301db9f49f031e6f463c0207de1d8 | p3@Gm10420, p3@Gm5786, p3@Gm8842, p3@Rps2 |
| 9.5e-23 | FFCP PHASE1:Mm9::chr19:6497758..6497764,+#_9f0301db9f49f031e6f463c0207de1d8 | p17@Nrxn2 |
| 9.5e-23 | FFCP PHASE2:Mm9::chr15:103345675..103345685,+#_9f0301db9f49f031e6f463c0207de1d8 | p10@Pde1b |
| 9.5e-23 | FFCP PHASE1:Mm9::chr8:96678044..96678046,-#_9f0301db9f49f031e6f463c0207de1d8 | p@chr8:96678044..96678046, - |
| 9.5e-23 | FFCP PHASE1:Mm9::chr5:123689685..123689727,+#_9f0301db9f49f031e6f463c0207de1d8 | p@chr5:123689685..123689727, + |
| 9.5e-23 | FFCP PHASE1:Mm9::chr9:106363021..106363029,+#_9f0301db9f49f031e6f463c0207de1d8 | p11@Pcbp4 |
| 9.5e-23 | FFCP PHASE1:Mm9::chr8:87232404..87232415,-#_9f0301db9f49f031e6f463c0207de1d8 | p22@Nfix |
| 9.5e-23 | FFCP PHASE2:Mm9::chr8:87232404..87232415,-#_9f0301db9f49f031e6f463c0207de1d8 | p22@Nfix |
| 9.5e-23 | FFCP PHASE1:Mm9::chr15:103345675..103345685,+#_9f0301db9f49f031e6f463c0207de1d8 | p10@Pde1b |
| 9.5e-23 | FFCP PHASE1:Mm9::chr17:24856898..24856901,+#_9f0301db9f49f031e6f463c0207de1d8 | p3@Gm10420, p3@Gm5786, p3@Gm8842, p3@Rps2 |
| 9.5e-23 | FFCP PHASE2:Mm9::chr8:96678044..96678046,-#_9f0301db9f49f031e6f463c0207de1d8 | p@chr8:96678044..96678046, - |
| 1.4e-22 | FFCP PHASE1:Mm9::chr8:11006242..11006246,-#_e143c7b16aeaaa9a7892ef783d7f18ec | p@chr8:11006242..11006246, - |
| 1.4e-22 | FFCP PHASE2:Mm9::chr8:11006242..11006246,-#_e143c7b16aeaaa9a7892ef783d7f18ec | p@chr8:11006242..11006246, - |
| 1.8e-22 | FFCP PHASE2:Mm9::chr19:8788816..8788826,-#_4921b90938d728205d57b23d6acc96c4 | p14@Slc3a2 |
| 1.8e-22 | FFCP PHASE1:Mm9::chr19:8788816..8788826,-#_4921b90938d728205d57b23d6acc96c4 | p14@Slc3a2 |
| 2.32e-22 | FFCP PHASE2:Mm9::chr11:69478859..69478867,-#_6df47730ba1dce20c41605653c38d7db | p@chr11:69478859..69478867, - |
| 2.32e-22 | FFCP PHASE2:Mm9::chr6:48997958..48997979,-#_6df47730ba1dce20c41605653c38d7db | p@chr6:48997958..48997979, - |
| 2.32e-22 | FFCP PHASE1:Mm9::chr11:69478859..69478867,-#_6df47730ba1dce20c41605653c38d7db | p@chr11:69478859..69478867, - |
| 2.32e-22 | FFCP PHASE1:Mm9::chr6:48997958..48997979,-#_6df47730ba1dce20c41605653c38d7db | p@chr6:48997958..48997979, - |
| 2.97e-22 | FFCP PHASE1:Mm9::chr1:173164773..173164781,-#_5431e08ccc95008716559dc8eb96b4cf | p3@Fcer1g |
| 2.97e-22 | FFCP PHASE2:Mm9::chr1:173164773..173164781,-#_5431e08ccc95008716559dc8eb96b4cf | p3@Fcer1g |
| 4.07e-21 | FFCP PHASE2:Mm9::chr11:102749020..102749031,-#_b9dcf1da762ed0fb51bbab08c109366d | p@chr11:102749020..102749031, - |
| 4.07e-21 | FFCP PHASE1:Mm9::chr11:102749020..102749031,-#_b9dcf1da762ed0fb51bbab08c109366d | p@chr11:102749020..102749031, - |
