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Coexpression cluster:C3989: Difference between revisions

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|tf_chipseq_enrich=E2F1#1869;3:4.90738921487932:0.00846098534723939:0.0325736084001893!ELF1#1997;3:4.25809795880754:0.0129517987505461:0.046283203644299!ELK4#2005;2:10.823787772312:0.0109128471951648:0.0401977514977538!GABPB1#2553;3:7.06768383618217:0.00283221282541742:0.0154268006296949!MYC#4609;3:5.2222818716094:0.00702084375574015:0.0294856804329156!NFKB1#4790;3:5.48806342419384:0.00604938181565543:0.026982335573147!SIN3A#25942;3:5.40888472681514:0.00631896197799152:0.0277125249861198!SP1#6667;3:5.6983813781409:0.00540396270171217:0.0246811763941102!TFAP2A#7020;2:11.0124229153633:0.0105499065521556:0.0390204940468386!TFAP2C#7022;3:10.8092286098602:0.000791674657575313:0.00616291812481426!USF1#7391;3:6.36149927720796:0.0038840405729056:0.0190515364171373!ZZZ3#26009;1:79.8044041450777:0.012478437908258:0.0451634175457636
|tf_chipseq_enrich=E2F1#1869;3:4.90738921487932:0.00846098534723939:0.0325736084001893!ELF1#1997;3:4.25809795880754:0.0129517987505461:0.046283203644299!ELK4#2005;2:10.823787772312:0.0109128471951648:0.0401977514977538!GABPB1#2553;3:7.06768383618217:0.00283221282541742:0.0154268006296949!MYC#4609;3:5.2222818716094:0.00702084375574015:0.0294856804329156!NFKB1#4790;3:5.48806342419384:0.00604938181565543:0.026982335573147!SIN3A#25942;3:5.40888472681514:0.00631896197799152:0.0277125249861198!SP1#6667;3:5.6983813781409:0.00540396270171217:0.0246811763941102!TFAP2A#7020;2:11.0124229153633:0.0105499065521556:0.0390204940468386!TFAP2C#7022;3:10.8092286098602:0.000791674657575313:0.00616291812481426!USF1#7391;3:6.36149927720796:0.0038840405729056:0.0190515364171373!ZZZ3#26009;1:79.8044041450777:0.012478437908258:0.0451634175457636
|tfbs_overrepresentation=0.147255,0.0586687,0.00948065,0.0477154,0.199763,0.287811,0.0430074,0.414564,0.000541236,0.0257057,0.139423,0.225367,0.188771,0.125978,0.148679,0.0619003,0.140982,0.0982016,0.0528514,0.108057,0.188635,0.132577,0.081977,0.0948982,0.0415721,0.215492,0.209392,0.0907212,0.143747,0.0933697,0.204953,0.114046,0.0180314,0.208242,0.0665252,0.0844722,0.324808,0.0429682,0.120351,0.0667043,0.0964797,0.0246116,0.140039,0.184019,0.120917,0.0362416,0.0380166,0.18151,0.111283,0.121201,0.154071,0.0541794,0.0701653,0.0929951,0.198787,0.0384161,0.107455,0.0244227,0.0783235,0.105572,0.0294301,0.149417,0.108602,0.0759481,0.054569,0.0504887,0.352278,0.00183766,0.0860723,0.167053,0.378921,0.067678,0.089036,0.119383,0.00747605,0.0171177,0.0964936,0.0436945,0.0372495,0.00725252,0.0956287,0.226912,0.0425,0.114846,0.0472875,0.251834,0.064341,0.0235519,0.241734,0.062747,0.0857568,0.0495878,0.0953825,0.0473737,0.0853887,0.115028,0.0594776,0.153631,0.00444039,0.27413,0.0574857,0.276221,0.0105769,0.0370665,0.219088,0.0409286,0.0669887,0.338096,0.144217,0.269326,0.182599,0.0339971,0.149552,0.0176855,0.101221,0.0337525,0.0203386,0.0566549,0.139021,0.0838393,0.16671,0.214708,0.140123,0.0857827,0.102368,0.176912,0.0906875,0.0147934,0.0843604,0.134932,0.0595773,0.0748346,0.0572164,0.0227861,0.125792,0.108101,0.0648644,0.0553359,0.0330399,0.00395526,0.022776,0.127606,0.203923,0.155998,0.596561,0.0693171,0.0988228,0.0842275,0.0389418,0.120833,0.200647,0.143677,0.180712,0.0265818,0.0427088,0.117549,0.0747594,0.228385,0.0516985,0.0337251,0.227719,0.0952829,0.116642,0.0115024,0.273479,0.114283,0.0400322,0.127369,0.0403542,0.312091,0.179689,0.137725,0.46397,0.0541353,0.0799324,0.090079,0.140334,0.181817,0.178449,0.0356339,0.158844,0.122474,0.0274061,0.115574,0.0737247,0.118847,0.0178773,0.0401756,0.0828697,0.173562,0.107145,0.187297,0.122935,0.228812,0.112671,0.0470731,0.0782523,0.0602859,0.0676496,0.109673,0.0893019,0.060398,0.0308319,0.0606036,0.136451,0.037005,0.27358,0.15185,0.206299,0.178359,0.0458667,0.104357,0.121154,0.00662754,0.312578,0.169057,0.164202,0.100942,0.062995,0.10299,0.14193,0.0800546,0.15606,0.161026,0.0738599,0.00837667,0.138852,0.085973,0.060453,0.059896,0.569726,0.0859236,0.0418404,0.0765029,0.0959204,0.0931946,0.0472272,0.0381183,0.163502,0.214803,0.182472,0.00958651,0.0983991,0.0830921,0.116283,0.136838,0.0815104,0.111647,0.372804,0.117027,0.159052,0.185164,0.185743,0.0980288,0.0980899,0.159674,0.107242,0.201859,0.0695832,0.21774,0.0619218,0.1751,0.163376,0.128096,0.0345133,0.0810678,0.0811639,0.0920653,0.118078,0.0755168,0.278352,0.063292,0.254773,0.119261,0.0865903,0.0380459,0.130174,0.0124596,0.0381789,0.0691572,0.019623,0.20128,0.0319444,0.228731,0.335423,0.261644,0.261553,0.446302,0.373681,0.309233,0.147559,0.330703,0.395854,0.329568,0.178727,0.615744,0.271958,0.292154,0.405773,0.39729,0.581713,0.597171,0.0187414,0.362792,0.181715,0.423979,0.109988,0.330894,0.218329,0.107929,0.0821552,0.463191,0.280025,0.528324,0.520763,0.370782,0.101703,0.484505,0.253571,0.276829,0.301787,0.481778,0.316882,0.223503,0.503224,0.603208,0.283727,0.314747,0.0116619,0.291709,0.448095,0.212757,0.416816,0.292835,0.137839,0.0210941,0.373868,0.213592,0.0154652,0.18237,0.0359955,0.0964442,0.161148,0.275351,0.236471,0.185661,0.346319,0.0427964,0.0405716,0.0179843,0.503058,0.163222,0.169228,0.248634,0.281576,0.472384,0.163244,0.0670502,0.0730934,0.184794,0.0641718,0.176034,0.581837,0.412837,0.102184,0.188159,0.191921,0.120021,0.218623,0.312808,0.333034,0.0451077,0.0747529,0.229003,0.0897888,0.589326,0.154921,0.294698,0.34331,0.477304,0.289204,0.327108,0.0295492,0.278044,0.00692297,0.428671,0.228096,0.336314,0.19763,0.15631,0.20495,0.421464,0.141711,0.420626,0.516462,0.135248,0.335105,0.144809,0.145539,0.385517,0.0818086,0.119597,0.127215,0.252232,0.152681,0.0465712,0.137098,0.259235,0.134788,0.0985856,0.546222,0.293698,0.284593,0.343734,0.306556,0.305777,0.601433,0.503082,0.169823,0.284629,0.262537,0.359455,0.226257,0.0965765,0.102469,0.363685,0.130283,0.0538047,0.206222,0.171685,0.0224921,0.113671,0.269226,0.339277,0.552319,0.281425,0.141758,0.455379,0.168058,0.159617,0.238587,0.372281,0.232251,0.189515,0.0891382,0.0595618,0.171389,0.257493,0.347298,0.182325,0.34988,0.475069,0.404569,0.6408,0.0793778,0.316179,0.0697683,0.0556835,0.192544,0.0779981,0.0575676,0.144322,0.223391,0.203656,0.116981,0.441735,0.191777,0.111931,0.28934,0.0435386,0.303336,0.126478,0.134852,0.10689,0.273326,0.0627924,0.381386,0.0179103,0.303939,0.279795,0.390395,0.0464827,0.169603,0.114583,0.104559,0.0899537,0.0866966,0.15983,0.107111,0.0438639,0.00389058,0.123593,0.129156,0.210369,0.193675,0.346372,0.0499762,0.0828956,0.0666953,0.182185,0.111277,0.219383,0.332809,0.19559,0.132201,0.188694,0.0481795,0.199971,0.0966069,0.127758,0.175785,0.184486,0.169234,0.0876426,0.0952322,0.0112557,0.00220026,0.107043,0.0043762,0.00481323,0.173708,0.141119,0.0241568,0.0300692,0.131551,0.0445237,0.052362,0.208866,0.153187,0.0797897,0.0974211,0.160149,0.123526,0.090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}}
}}

Revision as of 16:28, 26 November 2012


Full id: C3989_pineal_pituitary_optic_spinal_corpus_substantia_thalamus



Phase1 CAGE Peaks

Hg19::chr1:61542891..61542920,+p12@NFIA
Hg19::chr3:101405675..101405733,+p@chr3:101405675..101405733
+
Hg19::chr7:7606626..7606650,-p@chr7:7606626..7606650
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism1.58e-41114
neural tube8.73e-2856
neural rod8.73e-2856
future spinal cord8.73e-2856
neural keel8.73e-2856
nervous system1.83e-2789
central nervous system2.01e-2681
regional part of nervous system5.50e-2653
regional part of brain5.50e-2653
brain6.97e-2468
future brain6.97e-2468
regional part of forebrain1.52e-2341
forebrain1.52e-2341
anterior neural tube1.52e-2341
future forebrain1.52e-2341
telencephalon3.52e-1934
brain grey matter3.65e-1934
gray matter3.65e-1934
neural plate5.72e-1882
presumptive neural plate5.72e-1882
regional part of telencephalon6.77e-1832
neurectoderm7.80e-1886
cerebral hemisphere8.05e-1832
pre-chordal neural plate3.34e-1461
regional part of cerebral cortex8.92e-1422
cerebral cortex1.55e-1325
pallium1.55e-1325
neocortex8.86e-1320
organ system subdivision9.40e-13223
ecto-epithelium5.28e-11104
ectoderm-derived structure6.84e-10171
ectoderm6.84e-10171
presumptive ectoderm6.84e-10171
neural nucleus3.51e-079
nucleus of brain3.51e-079
basal ganglion3.80e-079
nuclear complex of neuraxis3.80e-079
aggregate regional part of brain3.80e-079
collection of basal ganglia3.80e-079
cerebral subcortex3.80e-079


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F1#186934.907389214879320.008460985347239390.0325736084001893
ELF1#199734.258097958807540.01295179875054610.046283203644299
ELK4#2005210.8237877723120.01091284719516480.0401977514977538
GABPB1#255337.067683836182170.002832212825417420.0154268006296949
MYC#460935.22228187160940.007020843755740150.0294856804329156
NFKB1#479035.488063424193840.006049381815655430.026982335573147
SIN3A#2594235.408884726815140.006318961977991520.0277125249861198
SP1#666735.69838137814090.005403962701712170.0246811763941102
TFAP2A#7020211.01242291536330.01054990655215560.0390204940468386
TFAP2C#7022310.80922860986020.0007916746575753130.00616291812481426
USF1#739136.361499277207960.00388404057290560.0190515364171373
ZZZ3#26009179.80440414507770.0124784379082580.0451634175457636



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.