MCL coexpression mm9:591

Phase1 CAGE Peaks

	Short description
Mm9::chr10:22063208..22063220,+	p@chr10:22063208..22063220 +
Mm9::chr11:6192633..6192653,+	p8@Ogdh
Mm9::chr11:6192671..6192695,+	p4@Ogdh
Mm9::chr11:6192857..6192873,+	p@chr11:6192857..6192873 +
Mm9::chr11:6192879..6192901,+	p@chr11:6192879..6192901 +
Mm9::chr11:95686449..95686463,+	p@chr11:95686449..95686463 +
Mm9::chr1:74063293..74063302,-	p@chr1:74063293..74063302 -
Mm9::chr1:74063339..74063352,-	p@chr1:74063339..74063352 -
Mm9::chr1:74154930..74154944,-	p@chr1:74154930..74154944 -
Mm9::chr2:30270958..30270969,-	p9@Crat
Mm9::chr8:42102103..42102121,-	p7@Mtus1
Mm9::chrX:156576256..156576268,-	p3@Pdha1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	5.29291857872747e-05
GO:0005739	mitochondrion	0.000224485943461562
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	0.00048344881914575
GO:0006096	glycolysis	0.00048344881914575
GO:0006007	glucose catabolic process	0.00048344881914575
GO:0046365	monosaccharide catabolic process	0.00048344881914575
GO:0019320	hexose catabolic process	0.00048344881914575
GO:0046164	alcohol catabolic process	0.00048344881914575
GO:0044275	cellular carbohydrate catabolic process	0.000598117729282579
GO:0016052	carbohydrate catabolic process	0.000641168179667001
GO:0006006	glucose metabolic process	0.00105982972717645
GO:0004092	carnitine O-acetyltransferase activity	0.00117999570144423
GO:0050164	oxoglutarate dehydrogenase (NADP+) activity	0.00117999570144423
GO:0019318	hexose metabolic process	0.00148344954783774
GO:0005996	monosaccharide metabolic process	0.00148344954783774
GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity	0.00191733542995084
GO:0004738	pyruvate dehydrogenase activity	0.00242169834513759
GO:0030976	thiamin pyrophosphate binding	0.00242169834513759
GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity	0.00242169834513759
GO:0044444	cytoplasmic part	0.00275277858356794
GO:0016413	O-acetyltransferase activity	0.00284126494223344
GO:0044265	cellular macromolecule catabolic process	0.00284126494223344
GO:0044262	cellular carbohydrate metabolic process	0.00329753507447477
GO:0006066	alcohol metabolic process	0.00331374989964021
GO:0016406	carnitine O-acyltransferase activity	0.00368007399453356
GO:0009057	macromolecule catabolic process	0.00403332330099428
GO:0005975	carbohydrate metabolic process	0.00546562014632149
GO:0044248	cellular catabolic process	0.00725663534467636
GO:0009056	catabolic process	0.0115500949709336
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	0.0147945239064525
GO:0008374	O-acyltransferase activity	0.0148097630336227
GO:0005737	cytoplasm	0.0157018038464137
GO:0016491	oxidoreductase activity	0.0206757213662636
GO:0016407	acetyltransferase activity	0.0255988472166892
GO:0043231	intracellular membrane-bound organelle	0.0260679889230526
GO:0043227	membrane-bound organelle	0.0260679889230526
GO:0042579	microbody	0.0352708844022384
GO:0005777	peroxisome	0.0352708844022384
GO:0043229	intracellular organelle	0.0385290791314264
GO:0043226	organelle	0.0385290791314264
GO:0019842	vitamin binding	0.038950713132341
GO:0050662	coenzyme binding	0.041968713804469

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
primary circulatory organ	4.67e-08	18
heart	4.67e-08	18
primitive heart tube	4.67e-08	18
primary heart field	4.67e-08	18
anterior lateral plate mesoderm	4.67e-08	18
heart tube	4.67e-08	18
heart primordium	4.67e-08	18
cardiac mesoderm	4.67e-08	18
cardiogenic plate	4.67e-08	18
heart rudiment	4.67e-08	18
cardiovascular system	6.38e-07	23
circulatory system	6.38e-07	23

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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