MCL coexpression mm9:1677

Phase1 CAGE Peaks

	Short description
Mm9::chr15:39491058..39491131,+	p1@Rims2
Mm9::chr15:72378118..72378137,-	p@chr15:72378118..72378137 -
Mm9::chr1:75543215..75543229,+	p6@Slc4a3
Mm9::chr4:122878468..122878513,+	p4@Nt5c1a
Mm9::chr4:122878746..122878772,+	p2@Nt5c1a

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008253	5'-nucleotidase activity	0.0242162498772717
GO:0005452	inorganic anion exchanger activity	0.0242162498772717
GO:0008252	nucleotidase activity	0.0242162498772717
GO:0015380	anion exchanger activity	0.0242162498772717
GO:0015106	bicarbonate transmembrane transporter activity	0.0242162498772717
GO:0015301	anion:anion antiporter activity	0.0242162498772717
GO:0015108	chloride transmembrane transporter activity	0.0242162498772717
GO:0017137	Rab GTPase binding	0.0313776749010759
GO:0017156	calcium ion-dependent exocytosis	0.0313776749010759
GO:0030073	insulin secretion	0.0314828234138316
GO:0030072	peptide hormone secretion	0.0314828234138316
GO:0015103	inorganic anion transmembrane transporter activity	0.0314828234138316
GO:0002790	peptide secretion	0.0314828234138316
GO:0015297	antiporter activity	0.035735271435484
GO:0015833	peptide transport	0.035735271435484
GO:0046879	hormone secretion	0.0361407521892148
GO:0006836	neurotransmitter transport	0.0378365687345399
GO:0017016	Ras GTPase binding	0.0378365687345399
GO:0031267	small GTPase binding	0.0378365687345399
GO:0051020	GTPase binding	0.038755433051013
GO:0019933	cAMP-mediated signaling	0.0402543445152911
GO:0019935	cyclic-nucleotide-mediated signaling	0.040339193295129

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
structure with developmental contribution from neural crest	3.71e-23	92
central nervous system	6.97e-19	73
nervous system	1.48e-18	75
regional part of nervous system	3.51e-18	54
neurectoderm	1.35e-16	64
neural plate	1.35e-16	64
presumptive neural plate	1.35e-16	64
neural tube	1.83e-16	52
neural rod	1.83e-16	52
future spinal cord	1.83e-16	52
neural keel	1.83e-16	52
ectoderm-derived structure	5.68e-15	95
ectoderm	5.68e-15	95
presumptive ectoderm	5.68e-15	95
brain	6.05e-15	47
future brain	6.05e-15	47
regional part of brain	4.13e-14	46
ecto-epithelium	1.60e-12	73
anterior neural tube	3.19e-12	40
pre-chordal neural plate	5.25e-12	49
regional part of forebrain	1.60e-11	39
forebrain	1.60e-11	39
future forebrain	1.60e-11	39
gray matter	7.75e-10	34
occipital lobe	8.24e-10	10
visual cortex	8.24e-10	10
neocortex	8.24e-10	10
brain grey matter	2.19e-08	29
regional part of telencephalon	2.19e-08	29
telencephalon	2.19e-08	29
regional part of cerebral cortex	1.97e-07	17

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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