MCL coexpression mm9:1354

Phase1 CAGE Peaks

	Short description
Mm9::chr14:119498621..119498667,-	p1@Uggt2
Mm9::chr15:77137003..77137037,-	p4@Rbfox2
Mm9::chr15:77137042..77137081,-	p3@Rbfox2
Mm9::chr2:106814540..106814579,-	p1@2700007P21Rik
Mm9::chr6:124706496..124706545,-	p4@Atn1
Mm9::chr6:124706717..124706786,-	p1@Atn1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0009404	toxin metabolic process	0.00136963786774777
GO:0050827	toxin receptor binding	0.00136963786774777
GO:0009636	response to toxin	0.0173487463248051
GO:0019748	secondary metabolic process	0.029447214156577
GO:0003714	transcription corepressor activity	0.03067988823755

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	3.05e-11	23
neuroblast (sensu Vertebrata)	3.05e-11	23
electrically responsive cell	5.62e-11	39
electrically active cell	5.62e-11	39
neuron	2.46e-10	33
neuronal stem cell	2.46e-10	33
neuroblast	2.46e-10	33
electrically signaling cell	2.46e-10	33
non-terminally differentiated cell	4.07e-09	49
ectodermal cell	2.45e-08	44
neurectodermal cell	2.45e-08	44
neural cell	2.48e-08	43

Uber Anatomy

Ontology term	p-value	n
central nervous system	2.32e-22	73
regional part of nervous system	6.83e-22	54
nervous system	7.85e-22	75
neural tube	3.63e-20	52
neural rod	3.63e-20	52
future spinal cord	3.63e-20	52
neural keel	3.63e-20	52
ectoderm-derived structure	6.48e-20	95
ectoderm	6.48e-20	95
presumptive ectoderm	6.48e-20	95
neurectoderm	3.79e-19	64
neural plate	3.79e-19	64
presumptive neural plate	3.79e-19	64
ecto-epithelium	2.15e-18	73
brain	4.63e-18	47
future brain	4.63e-18	47
regional part of brain	1.93e-17	46
anterior neural tube	1.03e-15	40
gray matter	1.16e-15	34
structure with developmental contribution from neural crest	1.35e-15	92
pre-chordal neural plate	2.52e-15	49
regional part of forebrain	3.20e-15	39
forebrain	3.20e-15	39
future forebrain	3.20e-15	39
brain grey matter	2.54e-13	29
regional part of telencephalon	2.54e-13	29
telencephalon	2.54e-13	29
tube	6.70e-10	114
cerebral cortex	8.25e-10	21
cerebral hemisphere	8.25e-10	21
pallium	8.25e-10	21
anatomical conduit	1.33e-09	122
multi-cellular organism	1.68e-09	333
regional part of cerebral cortex	3.70e-08	17
occipital lobe	1.49e-07	10
visual cortex	1.49e-07	10
neocortex	1.49e-07	10
embryo	5.63e-07	320

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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