MCL coexpression mm9:3424

Phase1 CAGE Peaks

	Short description
Mm9::chr3:88182662..88182675,-	p1@Bglap2 p3@Bglap-rs1
Mm9::chr9:5345414..5345435,+	p2@Casp12
Mm9::chr9:5345450..5345505,+	p1@Casp12

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0006926	virus-infected cell apoptosis	0.0253095210488937
GO:0030968	unfolded protein response	0.0261331101426934
GO:0030693	caspase activity	0.0261331101426934
GO:0030500	regulation of bone mineralization	0.0261331101426934
GO:0006984	ER-nuclear signaling pathway	0.0261331101426934
GO:0030278	regulation of ossification	0.0261331101426934
GO:0030282	bone mineralization	0.0261331101426934
GO:0046850	regulation of bone remodeling	0.0261331101426934
GO:0006986	response to unfolded protein	0.0261331101426934
GO:0051789	response to protein stimulus	0.0261331101426934

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
autonomic neuron	1.48e-07	9

Uber Anatomy

Ontology term	p-value	n
peripheral nervous system	5.11e-08	11
autonomic nervous system	1.48e-07	9

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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