MCL coexpression mm9:3367

Phase1 CAGE Peaks

	Short description
Mm9::chr2:72817659..72817725,-	p5@Sp3
Mm9::chr5:65827045..65827068,-	p3@Ugdh
Mm9::chrX:71491739..71491777,-	p1@Flna

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0003979	UDP-glucose 6-dehydrogenase activity	0.0179119188313569
GO:0030224	monocyte differentiation	0.0179119188313569
GO:0045022	early endosome to late endosome transport	0.0179119188313569
GO:0001779	natural killer cell differentiation	0.0179119188313569
GO:0030851	granulocyte differentiation	0.0208938037877912
GO:0005080	protein kinase C binding	0.0208938037877912
GO:0030101	natural killer cell activation	0.0306926887979374
GO:0016197	endosome transport	0.0393673692167007
GO:0003690	double-stranded DNA binding	0.0393673692167007
GO:0051287	NAD binding	0.0393673692167007
GO:0001702	gastrulation with mouth forming second	0.0472530987051181
GO:0005802	trans-Golgi network	0.0472530987051181
GO:0030183	B cell differentiation	0.0472530987051181
GO:0030218	erythrocyte differentiation	0.0472530987051181
GO:0002573	myeloid leukocyte differentiation	0.047670960679287
GO:0019901	protein kinase binding	0.0496300293415669
GO:0043566	structure-specific DNA binding	0.0496300293415669
GO:0019900	kinase binding	0.0496300293415669

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
thoracic cavity element	1.12e-08	17
thoracic segment organ	1.12e-08	17
thoracic cavity	1.12e-08	17
thoracic segment of trunk	1.12e-08	17
respiratory primordium	1.12e-08	17
endoderm of foregut	1.12e-08	17
lung	3.71e-08	14
respiratory tube	3.71e-08	14
respiration organ	3.71e-08	14
pair of lungs	3.71e-08	14
lung primordium	3.71e-08	14
lung bud	3.71e-08	14

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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