MCL coexpression mm9:2068

Phase1 CAGE Peaks

	Short description
Mm9::chr13:38071380..38071398,-	p@chr13:38071380..38071398 -
Mm9::chr3:65185318..65185322,-	p@chr3:65185318..65185322 -
Mm9::chr6:28838574..28838577,+	p@chr6:28838574..28838577 +
Mm9::chr6:88454974..88454978,-	p@chr6:88454974..88454978 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005783	endoplasmic reticulum	0.00347010480930672
GO:0005784	translocon complex	0.0111744080782777
GO:0005791	rough endoplasmic reticulum	0.0111744080782777
GO:0030867	rough endoplasmic reticulum membrane	0.0111744080782777
GO:0006886	intracellular protein transport	0.0159407093075002
GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	0.0159407093075002
GO:0022884	macromolecule transmembrane transporter activity	0.0159407093075002
GO:0046907	intracellular transport	0.0159407093075002
GO:0008320	protein transmembrane transporter activity	0.0159407093075002
GO:0006613	cotranslational protein targeting to membrane	0.0159407093075002
GO:0030176	integral to endoplasmic reticulum membrane	0.0159407093075002
GO:0015031	protein transport	0.0159407093075002
GO:0031227	intrinsic to endoplasmic reticulum membrane	0.0159407093075002
GO:0045184	establishment of protein localization	0.0159407093075002
GO:0008104	protein localization	0.0159407093075002
GO:0051649	establishment of cellular localization	0.0159407093075002
GO:0006612	protein targeting to membrane	0.0159407093075002
GO:0051641	cellular localization	0.0159407093075002
GO:0033036	macromolecule localization	0.0159407093075002
GO:0044444	cytoplasmic part	0.0159407093075002
GO:0009306	protein secretion	0.0159407093075002
GO:0031301	integral to organelle membrane	0.0253324253186313
GO:0065002	intracellular protein transport across a membrane	0.0255365256537682
GO:0031300	intrinsic to organelle membrane	0.0255365256537682
GO:0005789	endoplasmic reticulum membrane	0.0311753307934355
GO:0042175	nuclear envelope-endoplasmic reticulum network	0.0312558327928293
GO:0044432	endoplasmic reticulum part	0.0329716736381077
GO:0015399	primary active transmembrane transporter activity	0.0489871804209735
GO:0015405	P-P-bond-hydrolysis-driven transmembrane transporter activity	0.0489871804209735

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
immaterial anatomical entity	6.57e-15	79
trunk	1.03e-12	90
trunk region element	1.07e-12	79
anatomical space	1.05e-10	57
anatomical cavity	3.02e-10	39
body cavity precursor	3.38e-10	38
body cavity	1.20e-09	37
body cavity or lining	1.20e-09	37
pancreas	1.83e-08	12
viscus	2.10e-07	19
subdivision of trunk	2.28e-07	66

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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