MCL coexpression mm9:1358

Phase1 CAGE Peaks

	Short description
Mm9::chr14:26588519..26588569,-	p1@Zcchc24
Mm9::chr15:78004386..78004418,-	p2@Ift27
Mm9::chr5:116102983..116103001,-	p1@Ccdc64
Mm9::chr5:137463227..137463253,+	p3@Plod3
Mm9::chr5:34000486..34000536,-	p2@Tmem129
Mm9::chr7:150238681..150238702,+	p1@Cd81

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008475	procollagen-lysine 5-dioxygenase activity	0.0207066553792883
GO:0030307	positive regulation of cell growth	0.0207066553792883
GO:0045793	positive regulation of cell size	0.0230048737377879
GO:0030890	positive regulation of B cell proliferation	0.037222988647217
GO:0031418	L-ascorbic acid binding	0.037222988647217
GO:0030888	regulation of B cell proliferation	0.037222988647217
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	0.037222988647217
GO:0050871	positive regulation of B cell activation	0.037222988647217
GO:0045927	positive regulation of growth	0.037222988647217
GO:0042100	B cell proliferation	0.037222988647217
GO:0032946	positive regulation of mononuclear cell proliferation	0.0392164037242194
GO:0050671	positive regulation of lymphocyte proliferation	0.0392164037242194
GO:0050864	regulation of B cell activation	0.0392164037242194
GO:0032944	regulation of mononuclear cell proliferation	0.0441788138872621
GO:0050670	regulation of lymphocyte proliferation	0.0441788138872621
GO:0051213	dioxygenase activity	0.0441788138872621
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	0.0441788138872621
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	0.0441788138872621
GO:0051251	positive regulation of lymphocyte activation	0.0441788138872621
GO:0032943	mononuclear cell proliferation	0.0472716327546309
GO:0046651	lymphocyte proliferation	0.0472716327546309
GO:0001558	regulation of cell growth	0.0472716327546309
GO:0051249	regulation of lymphocyte activation	0.0472716327546309
GO:0042113	B cell activation	0.0472716327546309
GO:0050865	regulation of cell activation	0.0472716327546309
GO:0016049	cell growth	0.0496599180348516

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
non-terminally differentiated cell	3.25e-07	49
oligodendrocyte precursor cell	6.68e-07	8

Uber Anatomy

Ontology term	p-value	n
tube	4.86e-15	114
anatomical conduit	1.97e-14	122
central nervous system	9.91e-09	73
nervous system	1.49e-08	75
structure with developmental contribution from neural crest	3.36e-08	92
cardiovascular system	3.32e-07	23
circulatory system	3.32e-07	23
epithelial tube	3.93e-07	47

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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