MCL coexpression mm9:1310

Phase1 CAGE Peaks

	Short description
Mm9::chr11:94426729..94426757,+	p@chr11:94426729..94426757 +
Mm9::chr18:10920920..10920940,+	p@chr18:10920920..10920940 +
Mm9::chr19:10751736..10751740,-	p@chr19:10751736..10751740 -
Mm9::chr1:133640588..133640606,+	p1@Slc26a9
Mm9::chr1:133640755..133640772,+	p@chr1:133640755..133640772 +
Mm9::chr4:134954228..134954250,+	p@chr4:134954228..134954250 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0015701	bicarbonate transport	0.0156643648946284
GO:0015301	anion:anion antiporter activity	0.0156643648946284
GO:0015106	bicarbonate transmembrane transporter activity	0.0156643648946284
GO:0006885	regulation of pH	0.0192207603386587
GO:0015103	inorganic anion transmembrane transporter activity	0.0239126128897673
GO:0015297	antiporter activity	0.027036612488319
GO:0016324	apical plasma membrane	0.029873557841563
GO:0006821	chloride transport	0.0314652936105574
GO:0045177	apical part of cell	0.0364840831430798
GO:0008509	anion transmembrane transporter activity	0.0477150928473999

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
stomach	1.45e-07	16
food storage organ	1.45e-07	16
lung	3.09e-07	14
respiratory tube	3.09e-07	14
respiration organ	3.09e-07	14
pair of lungs	3.09e-07	14
lung primordium	3.09e-07	14
lung bud	3.09e-07	14
thoracic cavity element	4.52e-07	17
thoracic segment organ	4.52e-07	17
thoracic cavity	4.52e-07	17
thoracic segment of trunk	4.52e-07	17
respiratory primordium	4.52e-07	17
endoderm of foregut	4.52e-07	17

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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