MCL coexpression mm9:776

Phase1 CAGE Peaks

	Short description
Mm9::chr11:114529884..114529921,+	p1@Rpl38
Mm9::chr15:76734500..76734522,+	p1@Rpl8
Mm9::chr17:34092603..34092631,-	p1@Gm10260 p1@Rps18
Mm9::chr1:72757833..72757870,+	p1@Gm14173 p1@Rpl37a
Mm9::chr2:179992110..179992133,+	p1@Gm5963 p1@Rps21
Mm9::chr4:3762742..3762749,-	p1@Rps20
Mm9::chr7:148633544..148633554,+	p1@Rplp2
Mm9::chr8:105389768..105389776,-	p1@Gm8730
Mm9::chr9:120480615..120480639,+	p1@Rpl14

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0003735	structural constituent of ribosome	1.12158341245474e-09
GO:0005840	ribosome	1.12158341245474e-09
GO:0006412	translation	8.64843970314163e-08
GO:0030529	ribonucleoprotein complex	8.64843970314163e-08
GO:0009059	macromolecule biosynthetic process	4.38474181368054e-07
GO:0044249	cellular biosynthetic process	1.43704854847439e-06
GO:0009058	biosynthetic process	5.6054167329473e-06
GO:0043232	intracellular non-membrane-bound organelle	1.53399351754213e-05
GO:0043228	non-membrane-bound organelle	1.53399351754213e-05
GO:0032991	macromolecular complex	6.01455326125107e-05
GO:0044267	cellular protein metabolic process	0.000202127295949223
GO:0044260	cellular macromolecule metabolic process	0.000202127295949223
GO:0010467	gene expression	0.000202127295949223
GO:0005830	cytosolic ribosome (sensu Eukaryota)	0.000202127295949223
GO:0019538	protein metabolic process	0.000202848986937148
GO:0033279	ribosomal subunit	0.000296038486067175
GO:0044444	cytoplasmic part	0.000325187293197688
GO:0044445	cytosolic part	0.000606120219334295
GO:0005737	cytoplasm	0.00444001011736896
GO:0043170	macromolecule metabolic process	0.00444001011736896
GO:0005842	cytosolic large ribosomal subunit (sensu Eukaryota)	0.00492637565283138
GO:0005829	cytosol	0.00625365607878693
GO:0005843	cytosolic small ribosomal subunit (sensu Eukaryota)	0.00699304871529693
GO:0044238	primary metabolic process	0.00740623914031388
GO:0044237	cellular metabolic process	0.00740623914031388
GO:0019843	rRNA binding	0.0101529563835987
GO:0003723	RNA binding	0.0118358102948665
GO:0015935	small ribosomal subunit	0.0118358102948665
GO:0043229	intracellular organelle	0.0118358102948665
GO:0043226	organelle	0.0118358102948665
GO:0015934	large ribosomal subunit	0.0118358102948665
GO:0006414	translational elongation	0.0164570234412212
GO:0043284	biopolymer biosynthetic process	0.0225029067506786
GO:0044424	intracellular part	0.0257399456334986
GO:0005622	intracellular	0.0296374758110184

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
animal cell	7.11e-29	115
eukaryotic cell	7.11e-29	115
somatic cell	3.08e-27	118
stem cell	8.20e-27	97
somatic stem cell	4.56e-24	91
multi fate stem cell	4.56e-24	91
motile cell	7.45e-23	54
connective tissue cell	4.51e-20	46
mesenchymal cell	4.51e-20	46
hematopoietic cell	4.14e-18	32
hematopoietic oligopotent progenitor cell	4.14e-18	32
hematopoietic stem cell	4.14e-18	32
angioblastic mesenchymal cell	4.14e-18	32
hematopoietic multipotent progenitor cell	4.14e-18	32
hematopoietic lineage restricted progenitor cell	7.00e-15	25
common myeloid progenitor	6.29e-11	19
leukocyte	4.37e-10	17
nongranular leukocyte	4.37e-10	17
nucleate cell	7.88e-10	16
myeloid cell	2.63e-09	16
lymphoid lineage restricted progenitor cell	1.55e-08	12
non-terminally differentiated cell	2.19e-08	49
lymphocyte	2.89e-08	13
common lymphoid progenitor	2.89e-08	13
T cell	6.70e-08	11
pro-T cell	6.70e-08	11
myeloid lineage restricted progenitor cell	1.14e-07	13
embryonic cell	1.65e-07	70
mature alpha-beta T cell	5.59e-07	9
alpha-beta T cell	5.59e-07	9
immature T cell	5.59e-07	9
mature T cell	5.59e-07	9
immature alpha-beta T cell	5.59e-07	9

Uber Anatomy

Ontology term	p-value	n
connective tissue	4.51e-20	46
bone marrow	2.59e-09	16
hemolymphoid system	9.40e-08	48
immune system	9.40e-08	48
hematopoietic system	9.65e-08	45
blood island	9.65e-08	45

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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