Coexpression cluster:C491

Full id: C491_Adipocyte_dura_aorta_Preadipocyte_heart_Fibroblast_epididymis

Phase1 CAGE Peaks

Hg19::chr10:22002796..22002833,+	p@chr10:22002796..22002833 +
Hg19::chr10:85462978..85462980,-	p@chr10:85462978..85462980 -
Hg19::chr12:15034824..15034835,+	p@chr12:15034824..15034835 +
Hg19::chr12:15034857..15034886,-	p@chr12:15034857..15034886 -
Hg19::chr12:15034903..15034944,-	p@chr12:15034903..15034944 -
Hg19::chr12:15034956..15034967,-	p@chr12:15034956..15034967 -
Hg19::chr12:15034968..15034990,-	p@chr12:15034968..15034990 -
Hg19::chr12:15035012..15035043,-	p@chr12:15035012..15035043 -
Hg19::chr12:15035058..15035069,+	p@chr12:15035058..15035069 +
Hg19::chr12:15035074..15035085,-	p@chr12:15035074..15035085 -
Hg19::chr12:15035100..15035219,-	p@chr12:15035100..15035219 -
Hg19::chr12:15035939..15035972,-	p@chr12:15035939..15035972 -
Hg19::chr12:15038779..15038798,-	p1@MGP
Hg19::chr12:15154767..15154778,+	p1@ENST00000542689
Hg19::chr1:231005253..231005263,-	p15@C1orf198
Hg19::chr4:84114490..84114492,-	p@chr4:84114490..84114492 -
Hg19::chr5:150407833..150407850,-	p8@CU690655
Hg19::chr9:93101022..93101028,+	p@chr9:93101022..93101028 +
Hg19::chrX:102757802..102757810,-	p1@RAB40A

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008147	structural constituent of bone	0.012949936385265
GO:0051592	response to calcium ion	0.012949936385265
GO:0048306	calcium-dependent protein binding	0.012949936385265
GO:0001502	cartilage condensation	0.012949936385265
GO:0030500	regulation of bone mineralization	0.012949936385265
GO:0009612	response to mechanical stimulus	0.014713887167521
GO:0030278	regulation of ossification	0.014713887167521
GO:0030282	bone mineralization	0.014713887167521
GO:0046850	regulation of bone remodeling	0.0156938887077954
GO:0010038	response to metal ion	0.0168662108026289
GO:0051216	cartilage development	0.0168662108026289
GO:0007584	response to nutrient	0.0168662108026289
GO:0030324	lung development	0.0168662108026289
GO:0010035	response to inorganic substance	0.0168662108026289
GO:0030323	respiratory tube development	0.0168662108026289
GO:0031667	response to nutrient levels	0.0220578331918385
GO:0009991	response to extracellular stimulus	0.0228343265070251
GO:0009725	response to hormone stimulus	0.0248296325447801
GO:0031214	biomineral formation	0.0258705156162679
GO:0001503	ossification	0.0258705156162679
GO:0046849	bone remodeling	0.026875288854357
GO:0048771	tissue remodeling	0.0280549957385919
GO:0035295	tube development	0.0298312385764
GO:0005201	extracellular matrix structural constituent	0.0298312385764
GO:0050954	sensory perception of mechanical stimulus	0.0298312385764
GO:0007605	sensory perception of sound	0.0298312385764
GO:0009628	response to abiotic stimulus	0.0358904978638971
GO:0001501	skeletal development	0.0438092210678937

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
adipocyte of omentum tissue	2.77e-13	3
fat cell	2.02e-09	15
adipocyte of breast	2.88e-09	2

Uber Anatomy

Ontology term	p-value	n
adult organism	3.61e-17	114
omentum	8.56e-17	6
peritoneum	8.56e-17	6
abdominal cavity	8.56e-17	6
visceral peritoneum	8.56e-17	6
perirenal fat	2.09e-09	2
heart	1.17e-08	24
primitive heart tube	1.17e-08	24
primary heart field	1.17e-08	24
anterior lateral plate mesoderm	1.17e-08	24
heart tube	1.17e-08	24
heart primordium	1.17e-08	24
cardiac mesoderm	1.17e-08	24
cardiogenic plate	1.17e-08	24
heart rudiment	1.17e-08	24
open tracheal system trachea	2.81e-08	2
cavity lining	3.26e-08	12
serous membrane	3.26e-08	12
body cavity	6.58e-08	46
subdivision of trunk	7.08e-08	112
body cavity precursor	8.97e-08	54
anatomical space	1.31e-07	95
primary circulatory organ	1.49e-07	27
compound organ	1.49e-07	68
body cavity or lining	2.73e-07	49

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.