Coexpression cluster:C2167

Full id: C2167_Mesenchymal_Renal_Preadipocyte_tenocyte_Adipocyte_mesenchymal_Multipotent

Phase1 CAGE Peaks

Hg19::chr11:76380944..76380989,-	p2@LRRC32
Hg19::chr11:76380996..76381024,-	p3@LRRC32
Hg19::chr11:76381029..76381041,-	p6@LRRC32
Hg19::chr11:76381054..76381072,-	p5@LRRC32

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

---

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
fibroblast	3.85e-12	76
preadipocyte	3.44e-11	12
mesodermal cell	1.51e-10	121
contractile cell	1.20e-09	59
fat cell	1.46e-09	15
endothelial cell of vascular tree	1.57e-09	24
endothelial cell	1.97e-09	36
muscle precursor cell	2.16e-09	58
myoblast	2.16e-09	58
multi-potent skeletal muscle stem cell	2.16e-09	58
muscle cell	4.85e-09	55
mesenchymal stem cell of adipose	1.46e-07	8
electrically responsive cell	2.59e-07	61
electrically active cell	2.59e-07	61
meso-epithelial cell	3.29e-07	45

Uber Anatomy

Ontology term	p-value	n
splanchnic layer of lateral plate mesoderm	1.91e-15	83
circulatory system	4.68e-15	112
vasculature	7.07e-15	78
vascular system	7.07e-15	78
cardiovascular system	3.71e-14	109
vessel	2.05e-13	68
adipose tissue	6.91e-11	14
mesoderm	9.58e-11	315
mesoderm-derived structure	9.58e-11	315
presumptive mesoderm	9.58e-11	315
epithelial vesicle	3.17e-10	78
primary circulatory organ	3.45e-10	27
epithelial tube	3.55e-10	117
epithelial tube open at both ends	9.50e-10	59
blood vessel	9.50e-10	59
blood vasculature	9.50e-10	59
vascular cord	9.50e-10	59
muscle tissue	1.65e-09	64
musculature	1.65e-09	64
musculature of body	1.65e-09	64
heart	3.19e-09	24
primitive heart tube	3.19e-09	24
primary heart field	3.19e-09	24
anterior lateral plate mesoderm	3.19e-09	24
heart tube	3.19e-09	24
heart primordium	3.19e-09	24
cardiac mesoderm	3.19e-09	24
cardiogenic plate	3.19e-09	24
heart rudiment	3.19e-09	24
skeletal muscle tissue	4.16e-09	62
striated muscle tissue	4.16e-09	62
myotome	4.16e-09	62
dense mesenchyme tissue	4.95e-09	73
paraxial mesoderm	6.41e-09	72
presumptive paraxial mesoderm	6.41e-09	72
somite	9.14e-09	71
presomitic mesoderm	9.14e-09	71
presumptive segmental plate	9.14e-09	71
dermomyotome	9.14e-09	71
trunk paraxial mesoderm	9.14e-09	71
trunk mesenchyme	4.05e-08	122
mesenchyme	4.34e-08	160
entire embryonic mesenchyme	4.34e-08	160
unilaminar epithelium	2.36e-07	148
cell layer	2.38e-07	309
lymphoid system	2.88e-07	10
anatomical conduit	3.04e-07	240
multi-cellular organism	4.03e-07	656
lymphatic vessel	6.09e-07	8
lymph vasculature	6.09e-07	8
lymphatic part of lymphoid system	6.09e-07	8
epithelium	8.21e-07	306

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
MAX#4149	4	6.45255550900712	0.000576761319564549	0.00484643780304143

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

---

This analysis result is provided for C0 - C305 clusters.