Coexpression cluster:C2093

Full id: C2093_mesenchymal_mucinous_bile_Fibroblast_lung_Smooth_liposarcoma

Phase1 CAGE Peaks

Hg19::chr11:108800197..108800208,+	p6@DDX10
Hg19::chr11:108800225..108800254,+	p4@DDX10
Hg19::chr11:108800264..108800294,+	p3@DDX10
Hg19::chr11:108800302..108800338,+	p2@DDX10

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
animal cell	7.84e-20	679
eukaryotic cell	7.84e-20	679
somatic cell	5.12e-18	588
embryonic cell	3.17e-14	250
native cell	1.10e-13	722
mesodermal cell	1.55e-12	121
muscle precursor cell	5.90e-11	58
myoblast	5.90e-11	58
multi-potent skeletal muscle stem cell	5.90e-11	58
fibroblast	6.87e-11	76
skin fibroblast	1.90e-10	23
muscle cell	1.19e-09	55
contractile cell	1.72e-09	59
non-terminally differentiated cell	2.12e-09	106
smooth muscle cell	1.50e-08	43
smooth muscle myoblast	1.50e-08	43
electrically responsive cell	3.73e-08	61
electrically active cell	3.73e-08	61
vascular associated smooth muscle cell	6.54e-08	32

Uber Anatomy

Ontology term	p-value	n
vasculature	7.14e-12	78
vascular system	7.14e-12	78
unilaminar epithelium	1.56e-11	148
systemic artery	4.94e-11	33
systemic arterial system	4.94e-11	33
artery	1.02e-10	42
arterial blood vessel	1.02e-10	42
arterial system	1.02e-10	42
musculoskeletal system	1.37e-09	167
skeletal muscle tissue	1.94e-09	62
striated muscle tissue	1.94e-09	62
myotome	1.94e-09	62
somite	5.47e-09	71
presomitic mesoderm	5.47e-09	71
presumptive segmental plate	5.47e-09	71
dermomyotome	5.47e-09	71
trunk paraxial mesoderm	5.47e-09	71
epithelial vesicle	7.90e-09	78
muscle tissue	9.10e-09	64
musculature	9.10e-09	64
musculature of body	9.10e-09	64
paraxial mesoderm	1.10e-08	72
presumptive paraxial mesoderm	1.10e-08	72
anatomical system	1.12e-08	624
anatomical group	1.43e-08	625
epithelial tube open at both ends	1.69e-08	59
blood vessel	1.69e-08	59
blood vasculature	1.69e-08	59
vascular cord	1.69e-08	59
dense mesenchyme tissue	2.15e-08	73
vessel	4.50e-08	68
cardiovascular system	6.06e-08	109
circulatory system	2.51e-07	112
epithelial tube	3.00e-07	117
trunk mesenchyme	7.08e-07	122
multilaminar epithelium	8.45e-07	83

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CEBPB#1051	4	7.97114762582482	0.000247638578809083	0.00267485009124437
EP300#2033	4	6.7739417262232	0.000474845982144264	0.00433500345534657
FOS#2353	4	8.9979553088944	0.000152514771116863	0.00194558326379309
FOSL2#2355	4	16.9302006045617	1.2165416097647e-05	0.000303087760453759
GATA2#2624	4	12.744931733554	3.78864877853583e-05	0.000719815699074957
JUN#3725	4	12.5128291923363	4.07770316866756e-05	0.000741806725714111
JUND#3727	4	6.99466394187103	0.00041768421781858	0.00390987918120953
NR3C1#2908	4	14.973023331173	1.98868032687801e-05	0.000441905924805984
RAD21#5885	4	10.3550338954563	8.6948481184721e-05	0.00129062143639157
STAT3#6774	4	10.5194649971542	8.16377768286615e-05	0.00122873148497025
USF1#7391	3	4.77112445790597	0.0137046588718802	0.0482683326449362

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.