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Coexpression cluster:C4155: Difference between revisions

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|ontology_enrichment_disease=DOID:8692!1.72e-08!31;DOID:2531!3.30e-08!51;DOID:0060083!3.30e-08!51;DOID:1240!5.52e-08!39
|ontology_enrichment_disease=DOID:8692!1.72e-08!31;DOID:2531!3.30e-08!51;DOID:0060083!3.30e-08!51;DOID:1240!5.52e-08!39
|ontology_enrichment_uberon=UBERON:0002384!6.75e-40!375;UBERON:0002390!1.56e-29!102;UBERON:0003061!1.56e-29!102;UBERON:0002193!1.15e-28!112;UBERON:0002371!6.04e-21!80;UBERON:0001474!6.40e-21!86;UBERON:0002204!7.17e-17!167;UBERON:0004765!1.20e-15!101;UBERON:0001434!1.20e-15!101;UBERON:0002405!2.92e-15!115;UBERON:0003081!4.89e-13!216;UBERON:0000178!1.42e-07!15;UBERON:0000179!1.42e-07!15;UBERON:0000463!1.42e-07!15
|ontology_enrichment_uberon=UBERON:0002384!6.75e-40!375;UBERON:0002390!1.56e-29!102;UBERON:0003061!1.56e-29!102;UBERON:0002193!1.15e-28!112;UBERON:0002371!6.04e-21!80;UBERON:0001474!6.40e-21!86;UBERON:0002204!7.17e-17!167;UBERON:0004765!1.20e-15!101;UBERON:0001434!1.20e-15!101;UBERON:0002405!2.92e-15!115;UBERON:0003081!4.89e-13!216;UBERON:0000178!1.42e-07!15;UBERON:0000179!1.42e-07!15;UBERON:0000463!1.42e-07!15
|tf_chipseq_enrich=BCLAF1#9774;3:21.6526476101218:9.8473954032885e-05:0.0013937554255645!CTCF#10664;3:5.36025637307503:0.006492509252767:0.0280125247397229!EGR1#1958;3:4.98817909481014:0.00805648813738344:0.0321308880200172!ELF1#1997;3:4.25809795880754:0.0129517987505461:0.0463402846765428!GABPB1#2553;3:7.06768383618217:0.00283221282541742:0.0154437150980927!GATA1#2623;3:13.5603081438004:0.000400961596378263:0.00388496411208363!MEF2A#4205;3:18.7432309096441:0.000151824390562247:0.00195155538780683!MYC#4609;3:5.2222818716094:0.00702084375574015:0.0295129764944957!NANOG#79923;3:29.2447784810127:3.99627955670032e-05:0.000738572713895284!NFKB1#4790;3:5.48806342419384:0.00604938181565543:0.0270100204114932!PAX5#5079;3:6.66956553117783:0.00337029099967726:0.0173240388677672!POU2F2#5452;3:9.10612405774252:0.00132416519268213:0.00883445052756669!RAD21#5885;3:10.3550338954563:0.000900491207356542:0.00665579626363127!SMC3#9126;3:15.0449328449328:0.000293582542037187:0.00309711788967896!SRF#6722;3:13.7971782621678:0.000380661502580019:0.00375658193971035!SUZ12#23512;3:50.1157809110629:7.93834897779404e-06:0.000223109049755606!YY1#7528;3:4.91117074985386:0.00844145534180826:0.0330082427063204!ZEB1#6935;3:16.8884320175439:0.000207548691732758:0.00243142768546018!ZNF143#7702;3:13.5008765522279:0.000406280496299717:0.00389744913686471
|tfbs_overrepresentation=0.147255,0.0586687,0.134243,0.0477154,0.199763,0.287811,0.0430074,0.0172144,0.03272,0.0257057,0.139423,0.0275521,0.188771,0.125978,0.148679,0.0619003,0.140982,0.0982016,0.0528514,0.108057,0.188635,0.132577,0.081977,0.0948982,0.0415721,0.215492,0.209392,0.0907212,0.143747,0.0933697,0.204953,0.114046,0.0180314,0.208242,0.0665252,0.0844722,0.688181,0.0429682,0.120351,0.0667043,0.0964797,0.0246116,0.140039,0.184019,0.120917,0.0362416,0.0380166,0.18151,0.111283,0.121201,0.154071,0.0541794,0.0701653,0.0929951,0.198787,0.0384161,0.107455,0.212709,0.00315066,0.105572,0.0294301,0.149417,0.108602,0.0759481,0.054569,0.0504887,0.0709764,0.0600088,0.0860723,0.167053,0.378921,0.067678,0.089036,0.119383,0.00747605,0.0171177,0.0964936,0.0436945,0.0372495,0.00725252,0.0956287,0.0279481,0.0425,0.114846,0.291327,0.0347684,0.064341,0.209032,0.608896,0.062747,0.0857568,0.0495878,0.0953825,0.0473737,0.0853887,0.115028,0.21992,0.000682869,0.0927458,0.27413,0.0574857,0.276221,0.141874,0.0370665,0.219088,0.0409286,0.0669887,0.338096,0.144217,0.269326,0.182599,0.0339971,0.149552,0.0176855,0.101221,0.0337525,0.0203386,0.0566549,0.139021,0.0838393,0.16671,0.214708,0.140123,0.0857827,0.102368,0.176912,0.0906875,0.0147934,0.0843604,0.134932,0.0595773,0.0748346,0.0572164,0.0227861,0.125792,0.108101,0.0648644,0.0553359,0.0330399,0.00395526,0.022776,0.127606,0.203923,0.155998,0.596561,0.0693171,0.0988228,0.0842275,0.0389418,0.120833,0.0216297,0.143677,0.180712,0.0265818,0.0427088,0.117549,0.0747594,0.228385,0.0516985,0.0337251,0.227719,0.0952829,0.116642,0.147788,0.273479,0.114283,0.0400322,0.00847953,0.0403542,0.312091,0.179689,0.137725,0.46397,0.0541353,0.0799324,0.090079,0.140334,0.181817,0.178449,0.0356339,0.158844,0.122474,0.0274061,0.115574,0.00278703,0.118847,0.183031,0.0401756,0.0828697,0.173562,0.107145,0.187297,0.122935,0.228812,0.112671,0.0470731,0.0782523,0.0602859,0.0676496,0.109673,0.0893019,0.060398,0.0308319,0.0606036,0.136451,0.259411,0.27358,0.15185,0.206299,0.178359,0.0458667,0.104357,0.121154,0.1129,0.312578,0.169057,0.164202,0.100942,0.062995,0.10299,0.14193,0.37245,0.15606,0.161026,0.0738599,0.126611,0.138852,0.085973,0.060453,0.059896,0.569726,0.0133328,0.0418404,0.0765029,0.0959204,0.0931946,0.0472272,0.263087,0.163502,0.214803,0.182472,0.348993,0.0983991,0.0830921,0.116283,0.136838,0.0815104,0.111647,0.372804,0.117027,0.159052,0.185164,0.185743,0.0980288,0.0980899,0.159674,0.107242,0.201859,0.0695832,0.582402,0.0619218,0.1751,0.163376,0.128096,0.0345133,0.0810678,0.0811639,0.0920653,0.118078,0.0755168,0.278352,0.063292,0.254773,0.446759,0.0865903,0.0380459,0.130174,0.219944,0.131316,0.198118,0.268011,0.051522,0.0986134,0.807281,0.0638737,0.261644,0.261553,0.446302,0.373681,0.309233,0.49143,0.330703,0.395854,0.329568,0.178727,0.615744,0.271958,0.292154,0.405773,0.39729,0.581713,0.00244849,0.187251,0.362792,0.181715,0.423979,0.109988,0.0620388,0.218329,0.107929,0.376924,0.463191,0.00436109,0.528324,0.520763,0.0117562,0.415647,0.484505,0.253571,0.276829,0.301787,0.481778,0.316882,0.223503,0.503224,0.0146955,0.283727,0.314747,0.577664,0.00529148,0.448095,0.0563639,0.416816,0.0478086,0.137839,0.439556,0.0120909,0.57762,0.00280546,0.18237,0.346458,0.248484,0.747852,0.275351,0.236471,0.185661,0.346319,0.0427964,0.270984,0.0772647,0.155555,0.513852,0.522083,0.248634,0.00471332,0.472384,0.163244,0.0670502,0.0730934,0.184794,0.0641718,0.176034,0.581837,0.412837,0.671377,0.188159,0.551561,0.120021,0.218623,0.312808,0.117923,0.0451077,0.0747529,0.229003,0.650179,0.0129683,0.154921,0.294698,0.34331,0.138202,0.0465597,0.000749204,0.0295492,0.278044,0.0263998,0.428671,0.228096,0.336314,0.19763,0.15631,0.20495,0.421464,0.48267,0.420626,0.165111,0.311758,0.335105,0.144809,0.0005766,0.385517,0.376191,0.447325,0.459928,0.252232,0.152681,0.0465712,0.137098,0.259235,0.134788,0.0985856,0.18767,0.293698,0.284593,0.343734,0.306556,0.305777,0.601433,0.155572,0.522888,0.284629,0.0379506,0.359455,0.226257,0.405955,0.41707,0.0110128,0.464871,0.166672,0.206222,0.525396,0.0224921,0.437176,0.269226,0.339277,0.552319,0.281425,0.141758,0.455379,0.520495,0.159617,0.238587,0.372281,0.232251,0.189515,0.0891382,0.0595618,0.524997,0.0769581,0.347298,0.539392,0.34988,0.475069,0.404569,0.6408,0.630264,0.000642687,0.0697683,0.0556835,0.192544,0.0779981,0.0575676,0.144322,0.223391,0.00166084,0.116981,0.11631,0.191777,0.111931,0.28934,0.0435386,0.303336,0.126478,0.134852,0.10689,0.273326,0.0627924,0.381386,0.0179103,0.303939,0.279795,0.390395,0.0464827,0.169603,0.114583,0.104559,0.0899537,0.0866966,0.15983,0.107111,0.0438639,0.00389058,0.123593,0.129156,0.210369,0.193675,0.346372,0.0499762,0.0828956,0.0666953,0.182185,0.111277,0.219383,0.332809,0.19559,0.132201,0.188694,0.0481795,0.199971,0.016022,0.127758,0.175785,0.184486,0.015204,0.0876426,0.0952322,0.0112557,0.222432,0.107043,0.275244,0.00481323,0.173708,0.141119,0.00187586,0.0300692,0.131551,0.0445237,0.052362,0.208866,0.153187,0.0797897,0.0974211,0.160149,0.123526,0.0906475,0.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0558058,0.28262,0.517717,0.137332,0.0145999,0.0656973,0.211746,0.220538,0.0801488,0.0757897,0.161801,0.193215,0.0549034,0.0779715,0.0561838,0.0417636,0.0345419,0.0388736,0.0355977,0.170307,0.201033,0.0488949,0.174921,0.370421,0.0330727,5.99252e-06,0.02609,0.0394698,0.0596469,0.419264,0.122476,0.108872,0.11002,0.26144,0.0286025,0.0470027,0.144567,0.038848,0.0874516,0.0550279,0.144067,0.253693,0.217069,0.190048,0.131088,0.394069,0.237101,0.286988,0.0761239,0.172491,0.0818785,0.182701,0.00836526,0.147698,0.141463,0.167267,0.140622,0.0889592,0.309588,0.28711,0.0473033,0.094881,0.445524,0.132886,0.0774373,0.109194,0.128564,0.131452,0.0306206,0.448776,0.051838,0.0993999,0.0500365,0.061829,0.0755121,0.0936516,0.144075,0.0340203,0.0741807,0.277091,0.153605,0.0926491,0.21727,0.289306,0.119215,0.192475,0.177967,0.547859,0.057571,0.047591,0.392974,0.0608699,0.175319,0.300597,0.0713214,0.223874,0.291114,0.0355833,0.125606,0.175094,0.0370461,0.0611073,0.206454,0.218192,0.108277,0.0673484,0.108748,0.0494066,0.0958493,0.205732,0.0755808,0.045654,0.110216,0.070276,0.226171,0.153469,0.0376916,0.13262,0.0450031,0.0539144,0.114242,0.0929549,0.172425,0.104948,0.221645,0.057168,0.234298,0.0759837,0.286863,0.152372,0.194941,0.218271,0.101607,0.327067,0.172982,0.340936,0.151597,0.0626744,0.191335,0.148574,0.504592,0.155821,0.0718905,0.0919008,0.0602373,0.144304,0.15063,0.0973823,0.0126914,0.170295,0.193653,0.137219,0.228144,0.251466,0.288096,0.11903,0.0838874,0.00806892,0.113145,0.112651,0.186638,0.174776,0.0948451,0.264079,0.249049,0.140533,0.0997756,0.257598,0.103667,0.113069,0.025556,0.16791,0.09066,0.220462,0.166967,0.188651,0.0813902,0.184948,0.156261,0.311847,0.161789,0.0590944,0.247324,0.178389,0.218229,0.231073,0.407281,0.252227,0.0360851,0.412187,0.131093,0.0434602,0.133616,0.0177337,0.36927,0.449036,0.407369,0.231447,0.544776,0.43956,0.0789454,0.42622,0.448797,0.197484,0.396996,0.36145,0.00202987,0.381071,0.580441,0.276075,0.11074,0.366326,0.390366,0.48809,0.50058,0.443185,0.522904,0.000322406,0.60734,0.227104,0.166658,0.000486104,0.38649,0.284625,0.504757,0.04783,0.144318,0.0465139,0.164197,0.462688,0.287881,0.0556235,0.478174,0.336276,0.132529,0.258219,0.119142,0.243383,0.191695,0.390974,0.149257,0.683217,0.161598,0.00310283,0.0868402,0.150692,0.00136122,0.37357,0.200632,0.00442036,0.0201095,0.399222,0.771991,0.20342,0.200493,0.20558,0.300504,0.25656,0.107337,0.349197,0.383291,0.156104,0.0104921,0.411941,0.0961477,0.314438,0.0101316,0.000835245,0.230581,0.120226,0.28424,0.20075,0.314429,0.181415,0.00475227,0.194707,0.0727621,0.408413,0.516511,0.322213,0.28903,0.33942,0.61031,0.387276,0.522605,0.0248202,0.537348,0.222037,0.0175112,0.416292,0.462712,0.382478,0.215157,0.204817,0.452428,0.138871,0.673493,0.166905,0.19783,0.0833851,0.316453,0.48065,0.175199,0.332919,0.373557,0.523625,0.408861,0.365487,0.534741,0.0140668,0.363192,0.236011,0.203486,0.273398,0.375787,0.4466,0.351067,0.275347,0.269604,0.305885,0.0317395,0.00133934,0.30666,0.303709,0.0323359,0.386538,0.508064,0.250964,0.383276,0.000432158,0.504711,0.220231,0.0355483,0.196976,0.191517,0.463751,0.0663581,0.307334,0.459728,0.283463,0.0517073,0.472935,0.399569,0.273281,0.368095,0.275089,0.384593,0.47795,0.359231,0.339729,0.197805,0.608187,0.387069,0.332774,0.52832,0.299887,0.0814305,0.205413,0.17639,0.0779009,0.276869,0.205298,0.0337138,0.18966,0.258854,0.188263,0.0719199,0.264884,0.162568,0.19104,0.163057,0.219428,0.208013,0.0900729,0.0953646,0.166124,0.252184,0.378361,0.00343724,0.20753,0.447185,0.179412,0.193601,0.220904,0.222977,0.341681,0.310674,0.21801,0.198614,0.186804,0.123324,0.199468,0.0325925,0.0933115,0.12405,0.179889,0.226869,0.27872,0.0855609,0.131118,0.20837,0.247588,0.222339,0.0673329,0.20847,0.266544,0.113092,0.145701,0.229428,0.162145,0.0284767,0.168748,0.0384949,0.0660995,0.0521984,0.0455518,0.268741,0.201602,0.350452,0.154941,0.120196,0.0986735,0.108462,0.0595618,0.21593,0.158479,0.220319,0.195218,0.000352159,0.259632,0.30793,0.180606,0.159884,0.257294,0.150733,0.217112,0.123917,0.184317,0.0183464,0.0723291,0.258496,0.261744,9.3702e-05,0.21382,0.207559,0.141867,0.193031,0.0339803,0.115972,0.0273485,0.246105,0.173026,0.200432,0.139785,0.197112,0.240478,0.156465,0.00899301,0.256963,0.222798,4.56383e-05,0.176789,0.0969345,0.202137,0.310405,0.280943,0.218161,0.0822373,0.202065,0.106739,0.0536053,0.0537737,0.15113,0.078016,0.0407233,0.0537355,0.319922,0.261724,0.211332,0.187731,0.233626,0.189559,0.0812887,0.0981146,0.064145,0.121913,0.0638699,0.104603,0.0663259,0.0762523,0.128736,0.109171,0.04411,0.066952,0.089609,0.0367455,0.13497,0.204393,0.295769,0.286691,0.347036,0.141729,0.263159,0.255956,0.200105,0.227491,0.29837,0.253509,0.177664,0.28365,0.264413,0.131761,0.160658,0.206239,0.19924,0.28689,0.236464,0.325148,0.115817,0.0257187,0.223831,0.11528,0.194982,0.190993,0.281727,0.283218,0.249955,0.164638,0.224257,0.0935776,0.327622,0.225752,0.207791,0.0958756,0.0859274,0.316866,0.171683,0.158847,0.271275,0.071111,0.270604,0.101021,0.222548,0.175934,0.15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}}
}}

Revision as of 12:53, 5 September 2012


Full id: C4155_granulocyte_CD14_CD14CD16_acute_CD4_Preadipocyte_CD133



Phase1 CAGE Peaks

Hg19::chr2:182322231..182322262,+p2@ITGA4
Hg19::chr2:182322274..182322290,+p8@ITGA4
Hg19::chr2:182322344..182322359,+p6@ITGA4


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell5.89e-48172
angioblastic mesenchymal cell5.89e-48172
hematopoietic cell2.04e-45182
multi fate stem cell2.76e-45430
hematopoietic oligopotent progenitor cell1.78e-44165
hematopoietic multipotent progenitor cell1.78e-44165
stem cell8.39e-44444
somatic stem cell1.91e-43436
connective tissue cell5.85e-41365
mesenchymal cell6.34e-41358
leukocyte5.62e-39140
motile cell6.60e-35390
nongranular leukocyte4.26e-33119
hematopoietic lineage restricted progenitor cell1.18e-31124
myeloid cell1.66e-31112
common myeloid progenitor1.66e-31112
myeloid leukocyte7.26e-2576
CD14-positive, CD16-negative classical monocyte5.59e-2342
granulocyte monocyte progenitor cell2.87e-2171
myeloid lineage restricted progenitor cell6.97e-2170
monopoietic cell3.41e-2063
monocyte3.41e-2063
monoblast3.41e-2063
promonocyte3.41e-2063
macrophage dendritic cell progenitor2.30e-1965
classical monocyte4.99e-1945
somatic cell4.58e-16591
lymphocyte2.06e-1153
common lymphoid progenitor2.06e-1153
lymphoid lineage restricted progenitor cell2.07e-1152
intermediate monocyte2.88e-079
CD14-positive, CD16-positive monocyte2.88e-079
Uber Anatomy
Ontology termp-valuen
connective tissue6.75e-40375
hematopoietic system1.56e-29102
blood island1.56e-29102
hemolymphoid system1.15e-28112
bone marrow6.04e-2180
bone element6.40e-2186
musculoskeletal system7.17e-17167
skeletal element1.20e-15101
skeletal system1.20e-15101
immune system2.92e-15115
lateral plate mesoderm4.89e-13216
blood1.42e-0715
haemolymphatic fluid1.42e-0715
organism substance1.42e-0715
Disease
Ontology termp-valuen
myeloid leukemia1.72e-0831
hematologic cancer3.30e-0851
immune system cancer3.30e-0851
leukemia5.52e-0839


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCLAF1#9774321.65264761012189.8473954032885e-050.0013937554255645
CTCF#1066435.360256373075030.0064925092527670.0280125247397229
EGR1#195834.988179094810140.008056488137383440.0321308880200172
ELF1#199734.258097958807540.01295179875054610.0463402846765428
GABPB1#255337.067683836182170.002832212825417420.0154437150980927
GATA1#2623313.56030814380040.0004009615963782630.00388496411208363
MEF2A#4205318.74323090964410.0001518243905622470.00195155538780683
MYC#460935.22228187160940.007020843755740150.0295129764944957
NANOG#79923329.24477848101273.99627955670032e-050.000738572713895284
NFKB1#479035.488063424193840.006049381815655430.0270100204114932
PAX5#507936.669565531177830.003370290999677260.0173240388677672
POU2F2#545239.106124057742520.001324165192682130.00883445052756669
RAD21#5885310.35503389545630.0009004912073565420.00665579626363127
SMC3#9126315.04493284493280.0002935825420371870.00309711788967896
SRF#6722313.79717826216780.0003806615025800190.00375658193971035
SUZ12#23512350.11578091106297.93834897779404e-060.000223109049755606
YY1#752834.911170749853860.008441455341808260.0330082427063204
ZEB1#6935316.88843201754390.0002075486917327580.00243142768546018
ZNF143#7702313.50087655222790.0004062804962997170.00389744913686471



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.