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Coexpression cluster:C3475: Difference between revisions

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|ontology_enrichment_disease=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0000475!9.60e-18!365;UBERON:0003075!6.95e-17!86;UBERON:0007284!6.95e-17!86;UBERON:0002346!2.96e-16!90;UBERON:0000119!3.54e-16!312;UBERON:0000483!2.18e-15!309;UBERON:0003056!1.69e-13!61;UBERON:0000468!2.09e-13!659;UBERON:0005743!3.11e-13!86;UBERON:0000033!3.15e-12!123;UBERON:0001017!5.38e-12!82;UBERON:0000073!7.18e-12!94;UBERON:0001016!7.18e-12!94;UBERON:0000153!9.99e-12!129;UBERON:0007811!9.99e-12!129;UBERON:0004121!1.35e-11!169;UBERON:0000924!2.12e-11!173;UBERON:0006601!2.12e-11!173;UBERON:0000025!3.42e-11!194;UBERON:0001049!1.38e-10!57;UBERON:0005068!1.38e-10!57;UBERON:0006241!1.38e-10!57;UBERON:0007135!1.38e-10!57;UBERON:0002616!1.66e-10!59;UBERON:0007023!1.96e-10!115;UBERON:0000481!2.02e-10!347;UBERON:0004111!1.01e-09!241;UBERON:0000477!1.88e-09!286;UBERON:0000467!2.26e-09!625;UBERON:0000480!3.82e-09!626;UBERON:0000064!4.37e-09!219;UBERON:0000955!4.95e-09!69;UBERON:0006238!4.95e-09!69;UBERON:0003080!1.75e-08!42;UBERON:0000922!1.98e-08!612;UBERON:0002780!2.34e-08!41;UBERON:0001890!2.34e-08!41;UBERON:0006240!2.34e-08!41;UBERON:0002385!2.51e-08!63;UBERON:0001015!2.51e-08!63;UBERON:0000383!2.51e-08!63;UBERON:0000914!2.75e-08!83;UBERON:0002329!2.75e-08!83;UBERON:0003077!2.75e-08!83;UBERON:0003059!2.75e-08!83;UBERON:0007282!2.75e-08!83;UBERON:0009618!2.75e-08!83;UBERON:0007285!2.75e-08!83;UBERON:0001134!3.65e-08!61;UBERON:0002036!3.65e-08!61;UBERON:0003082!3.65e-08!61;UBERON:0005256!1.21e-07!143;UBERON:0002050!1.42e-07!605;UBERON:0005423!1.42e-07!605;UBERON:0004290!1.99e-07!70;UBERON:0001013!2.13e-07!14;UBERON:0000923!2.72e-07!604;UBERON:0005291!2.72e-07!604;UBERON:0006598!2.72e-07!604;UBERON:0002532!2.72e-07!604;UBERON:0002104!2.96e-07!21;UBERON:0001893!4.36e-07!34;UBERON:0001869!4.46e-07!32;UBERON:0000486!4.53e-07!82;UBERON:0001032!5.85e-07!24;UBERON:0004456!5.85e-07!24;UBERON:0002020!6.55e-07!34;UBERON:0003528!6.55e-07!34;UBERON:0000970!6.97e-07!20;UBERON:0002049!7.86e-07!79;UBERON:0007798!7.86e-07!79;UBERON:0002791!8.18e-07!33
|ontology_enrichment_uberon=UBERON:0000475!9.60e-18!365;UBERON:0003075!6.95e-17!86;UBERON:0007284!6.95e-17!86;UBERON:0002346!2.96e-16!90;UBERON:0000119!3.54e-16!312;UBERON:0000483!2.18e-15!309;UBERON:0003056!1.69e-13!61;UBERON:0000468!2.09e-13!659;UBERON:0005743!3.11e-13!86;UBERON:0000033!3.15e-12!123;UBERON:0001017!5.38e-12!82;UBERON:0000073!7.18e-12!94;UBERON:0001016!7.18e-12!94;UBERON:0000153!9.99e-12!129;UBERON:0007811!9.99e-12!129;UBERON:0004121!1.35e-11!169;UBERON:0000924!2.12e-11!173;UBERON:0006601!2.12e-11!173;UBERON:0000025!3.42e-11!194;UBERON:0001049!1.38e-10!57;UBERON:0005068!1.38e-10!57;UBERON:0006241!1.38e-10!57;UBERON:0007135!1.38e-10!57;UBERON:0002616!1.66e-10!59;UBERON:0007023!1.96e-10!115;UBERON:0000481!2.02e-10!347;UBERON:0004111!1.01e-09!241;UBERON:0000477!1.88e-09!286;UBERON:0000467!2.26e-09!625;UBERON:0000480!3.82e-09!626;UBERON:0000064!4.37e-09!219;UBERON:0000955!4.95e-09!69;UBERON:0006238!4.95e-09!69;UBERON:0003080!1.75e-08!42;UBERON:0000922!1.98e-08!612;UBERON:0002780!2.34e-08!41;UBERON:0001890!2.34e-08!41;UBERON:0006240!2.34e-08!41;UBERON:0002385!2.51e-08!63;UBERON:0001015!2.51e-08!63;UBERON:0000383!2.51e-08!63;UBERON:0000914!2.75e-08!83;UBERON:0002329!2.75e-08!83;UBERON:0003077!2.75e-08!83;UBERON:0003059!2.75e-08!83;UBERON:0007282!2.75e-08!83;UBERON:0009618!2.75e-08!83;UBERON:0007285!2.75e-08!83;UBERON:0001134!3.65e-08!61;UBERON:0002036!3.65e-08!61;UBERON:0003082!3.65e-08!61;UBERON:0005256!1.21e-07!143;UBERON:0002050!1.42e-07!605;UBERON:0005423!1.42e-07!605;UBERON:0004290!1.99e-07!70;UBERON:0001013!2.13e-07!14;UBERON:0000923!2.72e-07!604;UBERON:0005291!2.72e-07!604;UBERON:0006598!2.72e-07!604;UBERON:0002532!2.72e-07!604;UBERON:0002104!2.96e-07!21;UBERON:0001893!4.36e-07!34;UBERON:0001869!4.46e-07!32;UBERON:0000486!4.53e-07!82;UBERON:0001032!5.85e-07!24;UBERON:0004456!5.85e-07!24;UBERON:0002020!6.55e-07!34;UBERON:0003528!6.55e-07!34;UBERON:0000970!6.97e-07!20;UBERON:0002049!7.86e-07!79;UBERON:0007798!7.86e-07!79;UBERON:0002791!8.18e-07!33
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}}
}}

Revision as of 13:11, 5 September 2012


Full id: C3475_skeletal_Mesenchymal_Alveolar_brain_Hepatic_Adipocyte_mature



Phase1 CAGE Peaks

Hg19::chr15:23932389..23932401,-p3@NDN
Hg19::chr15:23932412..23932434,-p2@NDN
Hg19::chr15:23932437..23932459,-p1@NDN


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
organism subdivision9.60e-18365
neural plate6.95e-1786
presumptive neural plate6.95e-1786
neurectoderm2.96e-1690
cell layer3.54e-16312
epithelium2.18e-15309
pre-chordal neural plate1.69e-1361
multi-cellular organism2.09e-13659
head3.15e-12123
central nervous system5.38e-1282
regional part of nervous system7.18e-1294
nervous system7.18e-1294
anterior region of body9.99e-12129
craniocervical region9.99e-12129
ectoderm-derived structure1.35e-11169
ectoderm2.12e-11173
presumptive ectoderm2.12e-11173
tube3.42e-11194
neural tube1.38e-1057
neural rod1.38e-1057
future spinal cord1.38e-1057
neural keel1.38e-1057
regional part of brain1.66e-1059
adult organism1.96e-10115
multi-tissue structure2.02e-10347
anatomical conduit1.01e-09241
anatomical cluster1.88e-09286
anatomical system2.26e-09625
anatomical group3.82e-09626
organ part4.37e-09219
brain4.95e-0969
future brain4.95e-0969
anterior neural tube1.75e-0842
embryo1.98e-08612
regional part of forebrain2.34e-0841
forebrain2.34e-0841
future forebrain2.34e-0841
muscle tissue2.51e-0863
musculature2.51e-0863
musculature of body2.51e-0863
somite2.75e-0883
paraxial mesoderm2.75e-0883
presomitic mesoderm2.75e-0883
presumptive segmental plate2.75e-0883
trunk paraxial mesoderm2.75e-0883
presumptive paraxial mesoderm2.75e-0883
skeletal muscle tissue3.65e-0861
striated muscle tissue3.65e-0861
myotome3.65e-0861
trunk mesenchyme1.21e-07143
embryonic structure1.42e-07605
developing anatomical structure1.42e-07605
dermomyotome1.99e-0770
adipose tissue2.13e-0714
germ layer2.72e-07604
embryonic tissue2.72e-07604
presumptive structure2.72e-07604
epiblast (generic)2.72e-07604
visual system2.96e-0721
telencephalon4.36e-0734
cerebral hemisphere4.46e-0732
multilaminar epithelium4.53e-0782
sensory system5.85e-0724
entire sense organ system5.85e-0724
gray matter6.55e-0734
brain grey matter6.55e-0734
eye6.97e-0720
vasculature7.86e-0779
vascular system7.86e-0779
regional part of telencephalon8.18e-0733


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F6#187635.017155731697390.00791769806886330.0321357247246236
NRF1#4899312.21027944771090.0005492172401020010.00470354238122287
SPI1#668838.204323508522730.001810593189410520.0108951683630356



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.