Coexpression cluster:C1797

Full id: C1797_optic_vagina_paracentral_parietal_mature_frontal_occipital

Phase1 CAGE Peaks

Hg19::chr18:21851643..21851662,-	p5@OSBPL1A
Hg19::chr18:21851868..21851939,-	p4@OSBPL1A
Hg19::chr18:21851955..21851971,-	p7@OSBPL1A
Hg19::chr18:21851975..21851992,-	p6@OSBPL1A
Hg19::chr18:21852143..21852205,-	p2@OSBPL1A

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
adult organism	6.50e-38	115
ectoderm-derived structure	1.76e-28	169
organism subdivision	2.70e-28	365
head	2.72e-27	123
ectoderm	5.97e-27	173
presumptive ectoderm	5.97e-27	173
organ	4.05e-26	511
anterior region of body	7.97e-26	129
craniocervical region	7.97e-26	129
multi-tissue structure	8.20e-26	347
neural tube	1.02e-25	57
neural rod	1.02e-25	57
future spinal cord	1.02e-25	57
neural keel	1.02e-25	57
neural plate	1.25e-25	86
presumptive neural plate	1.25e-25	86
multi-cellular organism	2.44e-25	659
regional part of brain	6.11e-24	59
neurectoderm	2.18e-23	90
brain	2.76e-23	69
future brain	2.76e-23	69
anatomical system	1.62e-22	625
regional part of nervous system	2.56e-22	94
nervous system	2.56e-22	94
anatomical group	4.28e-22	626
central nervous system	4.48e-22	82
embryo	3.76e-21	612
anterior neural tube	4.49e-21	42
regional part of forebrain	1.85e-20	41
forebrain	1.85e-20	41
future forebrain	1.85e-20	41
embryonic structure	3.65e-20	605
developing anatomical structure	3.65e-20	605
germ layer	1.02e-19	604
embryonic tissue	1.02e-19	604
presumptive structure	1.02e-19	604
epiblast (generic)	1.02e-19	604
pre-chordal neural plate	2.91e-18	61
telencephalon	2.64e-17	34
organ part	2.77e-17	219
gray matter	3.62e-17	34
brain grey matter	3.62e-17	34
regional part of telencephalon	1.26e-16	33
cerebral hemisphere	4.30e-16	32
anatomical cluster	7.68e-15	286
cell layer	3.56e-14	312
regional part of cerebral cortex	4.14e-14	22
epithelium	6.01e-14	309
neocortex	5.09e-13	20
cerebral cortex	2.77e-12	25
pallium	2.77e-12	25
anatomical conduit	1.31e-11	241
endoderm-derived structure	9.33e-08	169
endoderm	9.33e-08	169
presumptive endoderm	9.33e-08	169
tube	1.40e-07	194
orifice	2.67e-07	35
digestive system	2.89e-07	155
digestive tract	2.89e-07	155
primitive gut	2.89e-07	155

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CTCF#10664	4	4.28820509846002	0.00515201558824328	0.0239355585418389
E2F1#1869	5	4.90738921487932	0.000351281809925646	0.00352764624488697
RAD21#5885	4	8.28402711636506	0.000401162263912245	0.00386681916758015
SP1#6667	4	4.55870510251272	0.0040757356578168	0.0194857292912213
TAF1#6872	5	3.34304628574529	0.00239460009087031	0.013535918970037
TBP#6908	5	3.70677068709639	0.00142875510672112	0.0091882853812098
ZNF263#10127	4	6.57747330960854	0.000987510323790016	0.00709218750559108

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.