Coexpression cluster:C1210

Full id: C1210_CD14_Mast_immature_Eosinophils_Basophils_Neutrophils_CD34

Phase1 CAGE Peaks

Hg19::chr15:52311403..52311461,+	p1@MAPK6
Hg19::chr17:30677160..30677200,+	p1@ZNF207
Hg19::chr1:94344686..94344748,-	p1@DNTTIP2
Hg19::chr1:94344754..94344768,-	p2@DNTTIP2
Hg19::chr2:178129358..178129403,-	p5@NFE2L2
Hg19::chr5:131132637..131132648,-	p2@FNIP1
Hg19::chr5:133561752..133561791,-	p1@PPP2CA p2@SKP1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	0.0370566280032591
GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein	0.0370566280032591
GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	0.0370566280032591
GO:0046426	negative regulation of JAK-STAT cascade	0.0370566280032591
GO:0033239	negative regulation of amine metabolic process	0.0370566280032591
GO:0001933	negative regulation of protein amino acid phosphorylation	0.0370566280032591
GO:0045763	negative regulation of amino acid metabolic process	0.0370566280032591
GO:0042516	regulation of tyrosine phosphorylation of Stat3 protein	0.0370566280032591
GO:0046983	protein dimerization activity	0.0370566280032591
GO:0042503	tyrosine phosphorylation of Stat3 protein	0.0370566280032591
GO:0042326	negative regulation of phosphorylation	0.0370566280032591
GO:0042509	regulation of tyrosine phosphorylation of STAT protein	0.0370566280032591
GO:0045936	negative regulation of phosphate metabolic process	0.0370566280032591
GO:0046425	regulation of JAK-STAT cascade	0.039697686838835
GO:0007260	tyrosine phosphorylation of STAT protein	0.0416733700027195
GO:0000188	inactivation of MAPK activity	0.0416733700027195

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
leukocyte	9.54e-34	140
myeloid leukocyte	1.76e-33	76
granulocyte monocyte progenitor cell	2.77e-30	71
myeloid lineage restricted progenitor cell	3.00e-29	70
hematopoietic stem cell	1.05e-28	172
angioblastic mesenchymal cell	1.05e-28	172
macrophage dendritic cell progenitor	2.29e-27	65
hematopoietic lineage restricted progenitor cell	4.99e-27	124
classical monocyte	9.59e-27	45
CD14-positive, CD16-negative classical monocyte	1.33e-26	42
hematopoietic oligopotent progenitor cell	2.13e-26	165
hematopoietic multipotent progenitor cell	2.13e-26	165
monopoietic cell	3.45e-26	63
monocyte	3.45e-26	63
monoblast	3.45e-26	63
promonocyte	3.45e-26	63
myeloid cell	3.81e-26	112
common myeloid progenitor	3.81e-26	112
hematopoietic cell	1.59e-25	182
nongranular leukocyte	1.13e-24	119
mesenchymal cell	2.42e-10	358
motile cell	1.42e-09	390
connective tissue cell	2.60e-09	365

Uber Anatomy

Ontology term	p-value	n
bone marrow	3.32e-25	80
bone element	3.63e-25	86
skeletal element	8.40e-22	101
skeletal system	8.40e-22	101
hematopoietic system	1.56e-21	102
blood island	1.56e-21	102
hemolymphoid system	4.93e-16	112
immune system	4.27e-14	115
connective tissue	7.10e-09	375

Disease

Ontology term	p-value	n
carcinoma	2.08e-08	106
cell type cancer	4.04e-07	143

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
ATF3#467	5	16.0451246614348	3.40064550879441e-06	0.000113469653767725
BHLHE40#8553	2	12.8205181562793	0.00967841018373383	0.0364201009288383
BRCA1#672	4	11.5338460818421	0.000186712149569376	0.00225956317368205
CCNT2#905	6	5.43102992311083	9.35028339706757e-05	0.00135837285812539
CHD2#1106	5	7.3885877386549	0.000149868960082067	0.00193236596568037
E2F1#1869	6	4.20633361275371	0.000413523201700764	0.00393763217199363
E2F4#1874	4	7.23889160873397	0.00111774143052487	0.00766586533113914
E2F6#1876	5	3.58368266549813	0.00459810189782724	0.0217255322162133
EGR1#1958	5	3.56298506772153	0.00472235121105893	0.0222592245399551
ELF1#1997	6	3.64979825040646	0.000937747978262069	0.00679036685167525
ETS1#2113	4	5.55929195554419	0.00302256447530346	0.0160501124281177
GTF2B#2959	3	13.6902128289961	0.000976196317024572	0.00701575606618011
GTF2F1#2962	3	5.45985466146756	0.013298821684157	0.0470260923606458
HEY1#23462	7	4.04011104310571	5.68979821988558e-05	0.000950170828728223
HMGN3#9324	4	4.67345584191462	0.00575188109993887	0.0259087686619734
IRF1#3659	7	7.6371637535639	6.59398174986938e-07	2.98771739685296e-05
JUND#3727	5	4.99618852990788	0.000973430860007092	0.00699684415611017
MAX#4149	5	4.60896822071937	0.00142433701403361	0.0091796564892722
MEF2A#4205	3	8.03281324699031	0.00451639783467502	0.0213539804181097
MXI1#4601	5	7.11540830625664	0.000179725622524823	0.00217930619887031
MYC#4609	5	3.73020133686386	0.00382194422230669	0.0188701381663825
NFKB1#4790	6	4.70405436359472	0.00021611506140197	0.00247731762679841
NR3C1#2908	3	6.41700999907416	0.00849722801565155	0.0324321893332833
NRF1#4899	4	6.97730254154909	0.0012853142886222	0.00861929748230472
POLR2A#5430	7	2.14745317655807	0.00474763644761028	0.022340094748906
REST#5978	6	8.27145318525259	7.89289295030691e-06	0.000222790769415433
SIN3A#25942	6	4.63618690869869	0.000235167814635783	0.00256562116293184
SIX5#147912	3	7.32287800948243	0.0058666762526916	0.0263315914373139
SP1#6667	5	4.07027241295778	0.00254920612899158	0.0141104801200844
SRF#6722	3	5.91307639807192	0.0106686813016745	0.0393928374214455
TAF1#6872	7	3.34304628574529	0.000214233631962245	0.00246603618301609
TAF7#6879	6	9.79977377564907	2.89681485118392e-06	9.9487157593817e-05
TBP#6908	7	3.70677068709639	0.000103967209750511	0.00145105324323582
TCF7L2#6934	4	6.15438660750705	0.00206467614813804	0.0119716140481561
USF2#7392	3	5.56808459360125	0.0125985343576105	0.0455554592588888
YY1#7528	6	4.20957492844616	0.00041168337886575	0.00392261658656692
ZBTB7A#51341	4	4.20109103307194	0.0084941066128735	0.0324285714483804
ZEB1#6935	3	7.23789943609022	0.0060628079203571	0.0268325110769631

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.