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{{UBERON
{{UBERON
|id=UBERON:0003091
|alt_id=UBERON:XAO_0000444-ZFA_0001081
|name=thyroid primordium
|namespace=
|def="The initial thyroid precursor, the thyroid primordium, starts as a simple midline thickening and develops to form the thyroid diverticulum. This structure is initially hollow, although it later solidifies and becomes bilobed. The 2 lobes are located on either side of the midline and are connected via an isthmus." [http://emedicine.medscape.com/article/845125-overview]
|xref=AAO:0011106;;BTO:0004709;;EHDAA2:0002033;;EHDAA:952;;EMAPA:16361;;EMAPA:16558;;ncithesaurus:Thyroid_Primordium;;TAO:0001081;;XAO:0000444;;ZFA:0001081
|is_a=UBERON:0000479;;UBERON:0001048;;UBERON:0004119
|synonym=
|comment=In all vertebrates the thyroid arises from the ventral aspect of the second pouch[PMID:16313389]. Note that we follow EHDAA2 in dividing this into endoderm and mesenchyme. In this ontology we place the broad developmental relationship at this level, and include specific relationships to the pharyngeal endoderm at the level of the endoderm
|comment=In all vertebrates the thyroid arises from the ventral aspect of the second pouch[PMID:16313389]. Note that we follow EHDAA2 in dividing this into endoderm and mesenchyme. In this ontology we place the broad developmental relationship at this level, and include specific relationships to the pharyngeal endoderm at the level of the endoderm
|alt_id=UBERON:XAO_0000444-ZFA_0001081
|disjoint_from=
|union_of=
|created_by=
|created_by=
|obo_creation_date=
|def="The initial thyroid precursor, the thyroid primordium, starts as a simple midline thickening and develops to form the thyroid diverticulum. This structure is initially hollow, although it later solidifies and becomes bilobed. The 2 lobes are located on either side of the midline and are connected via an isthmus." [http://emedicine.medscape.com/article/845125-overview]
|subset=vertebrate_core
|derives_from=
|derives_from=
|develops_from=UBERON:0007123
|develops_from=UBERON:0007123
|disjoint_from=
|has_quality=
|has_quality=
|id=UBERON:0003091
|is_a=UBERON:0000479 ;;UBERON:0001048 ;;UBERON:0004119
|is_obsolete=
|located_in=
|located_in=
|part_of=UBERON:0000949
|name=thyroid primordium
|namespace=
|obo_creation_date=
|part_of=UBERON:0000949;;UBERON:0001042
|preceded_by=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/uberon.owl
|is_obsolete=
|subset=vertebrate_core
|preceded_by=
|synonym=
|union_of=
|xref=AAO:0011106;;BTO:0004709;;EHDAA2:0002033;;EHDAA:952;;EMAPA:16361;;EMAPA:16558;;ncithesaurus:Thyroid_Primordium;;TAO:0001081;;XAO:0000444;;ZFA:0001081
}}
}}

Revision as of 11:21, 12 September 2014

Name:thyroid primordium
Definition:"The initial thyroid precursor, the thyroid primordium, starts as a simple midline thickening and develops to form the thyroid diverticulum. This structure is initially hollow, although it later solidifies and becomes bilobed. The 2 lobes are located on either side of the midline and are connected via an isthmus." [1]
Xrefs:
links:

AAO:0011106
BTO:0004709
EHDAA2:0002033
EHDAA:952
EMAPA:16361
EMAPA:16558
ncithesaurus:Thyroid_Primordium
TAO:0001081
XAO:0000444

ZFA:0001081
Comments:In all vertebrates the thyroid arises from the ventral aspect of the second pouch[PMID:16313389]. Note that we follow EHDAA2 in dividing this into endoderm and mesenchyme. In this ontology we place the broad developmental relationship at this level, and include specific relationships to the pharyngeal endoderm at the level of the endoderm
Alt_id: UBERON:XAO_0000444-ZFA_0001081
Subset: vertebrate_core

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:UBERON:0000479(tissue),UBERON:0001048(primordium),UBERON:0004119(endoderm-derived structure)
develops_from:UBERON:0007123(pharyngeal pouch 2)
part_of:UBERON:0000949(endocrine system),UBERON:0001042(chordate pharynx)



Children

develops from:UBERON:0007689 (thyroid diverticulum)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology



Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0003091 (thyroid primordium), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
7.76e-118FFCP PHASE2:Hg19::chr8:11333461..11333472,-#_2a5f35d1c98656a9c873763fd7c069aep@chr8:11333461..11333472, -
7.76e-118FFCP PHASE1:Hg19::chr8:11333461..11333472,-#_2a5f35d1c98656a9c873763fd7c069aep@chr8:11333461..11333472, -
6.64e-89FFCP PHASE1:Hg19::chr8:11333445..11333459,-#_616ed19853aa99de398910b3a48f1f3dp@chr8:11333445..11333459, -
6.64e-89FFCP PHASE2:Hg19::chr8:11333445..11333459,-#_616ed19853aa99de398910b3a48f1f3dp@chr8:11333445..11333459, -
3.18e-79FFCP PHASE2:Hg19::chr14:36645825..36645840,-#_813d8115df808fe225932533a08924cdp5@ENST00000556013
3.18e-79FFCP PHASE1:Hg19::chr14:36645825..36645840,-#_813d8115df808fe225932533a08924cdp5@ENST00000556013
3.49e-79FFCP PHASE1:Hg19::chr8:133981730..133981736,+#_12db51eae528a68c529160bb114e1dc3p38@TG
3.49e-79FFCP PHASE1:Hg19::chr2:1417430..1417444,+#_12db51eae528a68c529160bb114e1dc3p@chr2:1417430..1417444, +
3.49e-79FFCP PHASE2:Hg19::chr8:134107327..134107332,+#_12db51eae528a68c529160bb114e1dc3p29@TG
3.49e-79FFCP PHASE2:Hg19::chr8:133899413..133899418,+#_12db51eae528a68c529160bb114e1dc3p@chr8:133899413..133899418, +
3.49e-79FFCP PHASE2:Hg19::chr4:88047429..88047437,+#_12db51eae528a68c529160bb114e1dc3p@chr4:88047429..88047437, +
3.49e-79FFCP PHASE2:Hg19::chr8:133961114..133961122,+#_12db51eae528a68c529160bb114e1dc3p@chr8:133961114..133961122, +
3.49e-79FFCP PHASE1:Hg19::chr16:66420861..66420868,+#_12db51eae528a68c529160bb114e1dc3p@chr16:66420861..66420868, +
3.49e-79FFCP PHASE2:Hg19::chr2:134788853..134788858,-#_12db51eae528a68c529160bb114e1dc3p@chr2:134788853..134788858, -
3.49e-79FFCP PHASE2:Hg19::chr1:36771641..36771644,+#_12db51eae528a68c529160bb114e1dc3p11@SH3D21
3.49e-79FFCP PHASE2:Hg19::chr8:133953595..133953600,+#_12db51eae528a68c529160bb114e1dc3p@chr8:133953595..133953600, +
3.49e-79FFCP PHASE1:Hg19::chr8:133899244..133899254,-#_12db51eae528a68c529160bb114e1dc3p@chr8:133899244..133899254, -
3.49e-79FFCP PHASE1:Hg19::chr8:133882027..133882038,+#_12db51eae528a68c529160bb114e1dc3p@chr8:133882027..133882038, +
3.49e-79FFCP PHASE2:Hg19::chr8:133981730..133981736,+#_12db51eae528a68c529160bb114e1dc3p38@TG
3.49e-79FFCP PHASE1:Hg19::chr8:133894780..133894789,+#_12db51eae528a68c529160bb114e1dc3p@chr8:133894780..133894789, +
3.49e-79FFCP PHASE2:Hg19::chr2:1457500..1457511,+#_12db51eae528a68c529160bb114e1dc3p@chr2:1457500..1457511, +
3.49e-79FFCP PHASE1:Hg19::chr8:134107327..134107332,+#_12db51eae528a68c529160bb114e1dc3p29@TG
3.49e-79FFCP PHASE1:Hg19::chr8:133961114..133961122,+#_12db51eae528a68c529160bb114e1dc3p@chr8:133961114..133961122, +
3.49e-79FFCP PHASE1:Hg19::chr2:134788853..134788858,-#_12db51eae528a68c529160bb114e1dc3p@chr2:134788853..134788858, -
3.49e-79FFCP PHASE2:Hg19::chr8:133899244..133899254,-#_12db51eae528a68c529160bb114e1dc3p@chr8:133899244..133899254, -
3.49e-79FFCP PHASE1:Hg19::chr1:36771641..36771644,+#_12db51eae528a68c529160bb114e1dc3p11@SH3D21
3.49e-79FFCP PHASE1:Hg19::chr8:133953595..133953600,+#_12db51eae528a68c529160bb114e1dc3p@chr8:133953595..133953600, +
3.49e-79FFCP PHASE2:Hg19::chr8:133895164..133895167,+#_12db51eae528a68c529160bb114e1dc3p@chr8:133895164..133895167, +
3.49e-79FFCP PHASE1:Hg19::chr2:1457500..1457511,+#_12db51eae528a68c529160bb114e1dc3p@chr2:1457500..1457511, +
3.49e-79FFCP PHASE2:Hg19::chr8:134145709..134145716,+#_12db51eae528a68c529160bb114e1dc3p18@TG
3.49e-79FFCP PHASE1:Hg19::chr8:133898957..133898963,-#_12db51eae528a68c529160bb114e1dc3p@chr8:133898957..133898963, -
3.49e-79FFCP PHASE2:Hg19::chr6:43837226..43837237,-#_12db51eae528a68c529160bb114e1dc3p@chr6:43837226..43837237, -
3.49e-79FFCP PHASE2:Hg19::chr18:24321747..24321752,-#_12db51eae528a68c529160bb114e1dc3p@chr18:24321747..24321752, -
3.49e-79FFCP PHASE1:Hg19::chr8:133900307..133900325,-#_12db51eae528a68c529160bb114e1dc3p@chr8:133900307..133900325, -
3.49e-79FFCP PHASE2:Hg19::chr2:1426812..1426834,+#_12db51eae528a68c529160bb114e1dc3p5@TPO
3.49e-79FFCP PHASE2:Hg19::chr8:133898734..133898737,+#_12db51eae528a68c529160bb114e1dc3p@chr8:133898734..133898737, +
3.49e-79FFCP PHASE2:Hg19::chr8:133898957..133898963,-#_12db51eae528a68c529160bb114e1dc3p@chr8:133898957..133898963, -
3.49e-79FFCP PHASE1:Hg19::chr8:134145709..134145716,+#_12db51eae528a68c529160bb114e1dc3p18@TG
3.49e-79FFCP PHASE1:Hg19::chr8:133895164..133895167,+#_12db51eae528a68c529160bb114e1dc3p@chr8:133895164..133895167, +
3.49e-79FFCP PHASE2:Hg19::chr8:133900307..133900325,-#_12db51eae528a68c529160bb114e1dc3p@chr8:133900307..133900325, -
3.49e-79FFCP PHASE2:Hg19::chr2:1459933..1459941,+#_12db51eae528a68c529160bb114e1dc3p@chr2:1459933..1459941, +
3.49e-79FFCP PHASE2:Hg19::chr14:81421428..81421431,+#_12db51eae528a68c529160bb114e1dc3p11@TSHR
3.49e-79FFCP PHASE1:Hg19::chr2:1426812..1426834,+#_12db51eae528a68c529160bb114e1dc3p5@TPO
3.49e-79FFCP PHASE2:Hg19::chr2:1440068..1440076,+#_12db51eae528a68c529160bb114e1dc3p@chr2:1440068..1440076, +
3.49e-79FFCP PHASE1:Hg19::chr6:43837226..43837237,-#_12db51eae528a68c529160bb114e1dc3p@chr6:43837226..43837237, -
3.49e-79FFCP PHASE1:Hg19::chr18:24321747..24321752,-#_12db51eae528a68c529160bb114e1dc3p@chr18:24321747..24321752, -
3.49e-79FFCP PHASE1:Hg19::chr8:133981694..133981700,+#_12db51eae528a68c529160bb114e1dc3p35@TG
3.49e-79FFCP PHASE1:Hg19::chr7:107301447..107301451,+#_12db51eae528a68c529160bb114e1dc3p23@SLC26A4
3.49e-79FFCP PHASE2:Hg19::chr8:133885414..133885420,-#_12db51eae528a68c529160bb114e1dc3p@chr8:133885414..133885420, -
3.49e-79FFCP PHASE1:Hg19::chr8:133898734..133898737,+#_12db51eae528a68c529160bb114e1dc3p@chr8:133898734..133898737, +
3.49e-79FFCP PHASE2:Hg19::chr8:133895195..133895206,+#_12db51eae528a68c529160bb114e1dc3p@chr8:133895195..133895206, +
3.49e-79FFCP PHASE2:Hg19::chr8:11333494..11333497,-#_12db51eae528a68c529160bb114e1dc3p@chr8:11333494..11333497, -
3.49e-79FFCP PHASE1:Hg19::chr2:1459933..1459941,+#_12db51eae528a68c529160bb114e1dc3p@chr2:1459933..1459941, +
3.49e-79FFCP PHASE2:Hg19::chr8:134145732..134145736,+#_12db51eae528a68c529160bb114e1dc3p27@TG
3.49e-79FFCP PHASE1:Hg19::chr8:133899004..133899013,-#_12db51eae528a68c529160bb114e1dc3p@chr8:133899004..133899013, -
3.49e-79FFCP PHASE2:Hg19::chr8:133978809..133978829,+#_12db51eae528a68c529160bb114e1dc3p@chr8:133978809..133978829, +
3.49e-79FFCP PHASE2:Hg19::chr8:133981694..133981700,+#_12db51eae528a68c529160bb114e1dc3p35@TG
3.49e-79FFCP PHASE2:Hg19::chr7:107301447..107301451,+#_12db51eae528a68c529160bb114e1dc3p23@SLC26A4
3.49e-79FFCP PHASE1:Hg19::chr2:1440068..1440076,+#_12db51eae528a68c529160bb114e1dc3p@chr2:1440068..1440076, +
3.49e-79FFCP PHASE2:Hg19::chr8:133898904..133898911,+#_12db51eae528a68c529160bb114e1dc3p@chr8:133898904..133898911, +
3.49e-79FFCP PHASE1:Hg19::chr8:133900339..133900344,-#_12db51eae528a68c529160bb114e1dc3p@chr8:133900339..133900344, -
3.49e-79FFCP PHASE2:Hg19::chr8:134108463..134108470,+#_12db51eae528a68c529160bb114e1dc3p@chr8:134108463..134108470, +
3.49e-79FFCP PHASE1:Hg19::chr8:133885414..133885420,-#_12db51eae528a68c529160bb114e1dc3p@chr8:133885414..133885420, -
3.49e-79FFCP PHASE2:Hg19::chr2:1426850..1426859,+#_12db51eae528a68c529160bb114e1dc3p10@TPO
3.49e-79FFCP PHASE2:Hg19::chr8:133899004..133899013,-#_12db51eae528a68c529160bb114e1dc3p@chr8:133899004..133899013, -
3.49e-79FFCP PHASE1:Hg19::chr8:134145732..134145736,+#_12db51eae528a68c529160bb114e1dc3p27@TG
3.49e-79FFCP PHASE1:Hg19::chr15:64421903..64421920,+#_12db51eae528a68c529160bb114e1dc3p@chr15:64421903..64421920, +
3.49e-79FFCP PHASE1:Hg19::chr8:133895195..133895206,+#_12db51eae528a68c529160bb114e1dc3p@chr8:133895195..133895206, +
3.49e-79FFCP PHASE2:Hg19::chr7:88388628..88388669,+#_12db51eae528a68c529160bb114e1dc3p6@ZNF804B
3.49e-79FFCP PHASE1:Hg19::chr8:11333494..11333497,-#_12db51eae528a68c529160bb114e1dc3p@chr8:11333494..11333497, -
3.49e-79FFCP PHASE2:Hg19::chr8:133900339..133900344,-#_12db51eae528a68c529160bb114e1dc3p@chr8:133900339..133900344, -
3.49e-79FFCP PHASE2:Hg19::chr2:1459978..1459990,-#_12db51eae528a68c529160bb114e1dc3p@chr2:1459978..1459990, -
3.49e-79FFCP PHASE1:Hg19::chr8:133978809..133978829,+#_12db51eae528a68c529160bb114e1dc3p@chr8:133978809..133978829, +
3.49e-79FFCP PHASE2:Hg19::chr8:133906083..133906088,+#_12db51eae528a68c529160bb114e1dc3p@chr8:133906083..133906088, +
3.49e-79FFCP PHASE1:Hg19::chr8:134108463..134108470,+#_12db51eae528a68c529160bb114e1dc3p@chr8:134108463..134108470, +
3.49e-79FFCP PHASE2:Hg19::chr6:148533199..148533206,+#_12db51eae528a68c529160bb114e1dc3p@chr6:148533199..148533206, +
3.49e-79FFCP PHASE1:Hg19::chr2:1426850..1426859,+#_12db51eae528a68c529160bb114e1dc3p10@TPO
3.49e-79FFCP PHASE2:Hg19::chr2:1440089..1440096,+#_12db51eae528a68c529160bb114e1dc3p@chr2:1440089..1440096, +
3.49e-79FFCP PHASE1:Hg19::chr8:133898904..133898911,+#_12db51eae528a68c529160bb114e1dc3p@chr8:133898904..133898911, +
3.49e-79FFCP PHASE1:Hg19::chr8:133981703..133981711,+#_12db51eae528a68c529160bb114e1dc3p31@TG
3.49e-79FFCP PHASE1:Hg19::chr14:21560489..21560506,-#_12db51eae528a68c529160bb114e1dc3p@chr14:21560489..21560506, -
3.49e-79FFCP PHASE2:Hg19::chr8:133878995..133879011,+#_12db51eae528a68c529160bb114e1dc3p32@TG
3.49e-79FFCP PHASE2:Hg19::chr8:133935716..133935719,+#_12db51eae528a68c529160bb114e1dc3p@chr8:133935716..133935719, +
3.49e-79FFCP PHASE1:Hg19::chr7:88388628..88388669,+#_12db51eae528a68c529160bb114e1dc3p6@ZNF804B
3.49e-79FFCP PHASE2:Hg19::chr8:133895229..133895236,-#_12db51eae528a68c529160bb114e1dc3p@chr8:133895229..133895236, -
3.49e-79FFCP PHASE2:Hg19::chr7:107301340..107301345,+#_12db51eae528a68c529160bb114e1dc3p13@SLC26A4
3.49e-79FFCP PHASE2:Hg19::chr2:134788828..134788834,-#_12db51eae528a68c529160bb114e1dc3p@chr2:134788828..134788834, -
3.49e-79FFCP PHASE1:Hg19::chr2:1459978..1459990,-#_12db51eae528a68c529160bb114e1dc3p@chr2:1459978..1459990, -
3.49e-79FFCP PHASE1:Hg19::chr22:31521904..31521930,+#_12db51eae528a68c529160bb114e1dc3p@chr22:31521904..31521930, +
3.49e-79FFCP PHASE1:Hg19::chr8:133906083..133906088,+#_12db51eae528a68c529160bb114e1dc3p@chr8:133906083..133906088, +
3.49e-79FFCP PHASE1:Hg19::chr14:67998625..67998628,-#_12db51eae528a68c529160bb114e1dc3p@chr14:67998625..67998628, -
3.49e-79FFCP PHASE2:Hg19::chr8:133948038..133948045,+#_12db51eae528a68c529160bb114e1dc3p@chr8:133948038..133948045, +
3.49e-79FFCP PHASE1:Hg19::chr6:148533199..148533206,+#_12db51eae528a68c529160bb114e1dc3p@chr6:148533199..148533206, +
3.49e-79FFCP PHASE2:Hg19::chr8:133981703..133981711,+#_12db51eae528a68c529160bb114e1dc3p31@TG
3.49e-79FFCP PHASE1:Hg19::chr2:1440089..1440096,+#_12db51eae528a68c529160bb114e1dc3p@chr2:1440089..1440096, +
3.49e-79FFCP PHASE1:Hg19::chr8:133878995..133879011,+#_12db51eae528a68c529160bb114e1dc3p32@TG
3.49e-79FFCP PHASE1:Hg19::chr8:133935716..133935719,+#_12db51eae528a68c529160bb114e1dc3p@chr8:133935716..133935719, +
3.49e-79FFCP PHASE1:Hg19::chr8:133900347..133900354,-#_12db51eae528a68c529160bb114e1dc3p@chr8:133900347..133900354, -
3.49e-79FFCP PHASE2:Hg19::chr22:31521904..31521930,+#_12db51eae528a68c529160bb114e1dc3p@chr22:31521904..31521930, +
3.49e-79FFCP PHASE1:Hg19::chr7:107301340..107301345,+#_12db51eae528a68c529160bb114e1dc3p13@SLC26A4

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