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Coexpression cluster:C1620: Difference between revisions

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|ontology_enrichment_disease=
|ontology_enrichment_disease=
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}}
}}

Revision as of 17:29, 8 August 2012


Full id: C1620_spinal_occipital_optic_diencephalon_substantia_brain_corpus



Phase1 CAGE Peaks

Hg19::chr11:125366047..125366076,-p5@FEZ1
Hg19::chr11:125366089..125366207,-p1@FEZ1
Hg19::chr17:40126302..40126313,+p6@BC148241
Hg19::chr17:42984454..42984463,-p37@GFAP
Hg19::chr4:83551834..83551855,-p@chr4:83551834..83551855
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0043015gamma-tubulin binding0.0207887046966037
GO:0044430cytoskeletal part0.0207887046966037
GO:0005856cytoskeleton0.0322259237004165
GO:0007411axon guidance0.0322259237004165
GO:0015631tubulin binding0.0322259237004165
GO:0005200structural constituent of cytoskeleton0.0322259237004165
GO:0007409axonogenesis0.0322259237004165
GO:0048667neuron morphogenesis during differentiation0.0322259237004165
GO:0048812neurite morphogenesis0.0322259237004165
GO:0043232intracellular non-membrane-bound organelle0.0322259237004165
GO:0043228non-membrane-bound organelle0.0322259237004165
GO:0000904cellular morphogenesis during differentiation0.0322259237004165
GO:0005813centrosome0.0322259237004165
GO:0031175neurite development0.0322259237004165
GO:0005815microtubule organizing center0.0322259237004165
GO:0048666neuron development0.0322259237004165
GO:0032990cell part morphogenesis0.0323941803318015
GO:0048858cell projection morphogenesis0.0323941803318015
GO:0030030cell projection organization and biogenesis0.0323941803318015
GO:0030182neuron differentiation0.0323941803318015
GO:0016477cell migration0.0323941803318015
GO:0045111intermediate filament cytoskeleton0.0323941803318015
GO:0005882intermediate filament0.0323941803318015
GO:0048699generation of neurons0.0323941803318015
GO:0044446intracellular organelle part0.0323941803318015
GO:0044422organelle part0.0323941803318015
GO:0022008neurogenesis0.0324376738613004
GO:0051674localization of cell0.0440692668892321
GO:0006928cell motility0.0440692668892321



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
cell layer2.51e-33312
epithelium3.81e-33309
anatomical conduit3.78e-31241
neural tube9.29e-3057
neural rod9.29e-3057
future spinal cord9.29e-3057
neural keel9.29e-3057
tube5.56e-29194
central nervous system1.34e-2882
regional part of brain4.25e-2759
anatomical cluster1.02e-26286
regional part of nervous system3.05e-2694
nervous system3.05e-2694
neural plate4.37e-2686
presumptive neural plate4.37e-2686
ectoderm-derived structure2.50e-25169
head1.91e-24123
brain2.87e-2469
future brain2.87e-2469
ectoderm4.64e-24173
presumptive ectoderm4.64e-24173
neurectoderm5.31e-2490
organism subdivision4.56e-23365
anterior region of body6.50e-22129
craniocervical region6.50e-22129
regional part of forebrain3.82e-2141
forebrain3.82e-2141
future forebrain3.82e-2141
gray matter5.96e-2134
brain grey matter5.96e-2134
telencephalon6.43e-2134
anterior neural tube7.01e-2142
regional part of telencephalon2.63e-2033
cerebral hemisphere1.47e-1932
pre-chordal neural plate3.74e-1861
vessel1.55e-1769
vasculature1.93e-1779
vascular system1.93e-1779
blood vessel1.48e-1660
epithelial tube open at both ends1.48e-1660
blood vasculature1.48e-1660
vascular cord1.48e-1660
splanchnic layer of lateral plate mesoderm2.32e-1684
multi-tissue structure4.59e-16347
multi-cellular organism1.18e-15659
cerebral cortex2.16e-1525
pallium2.16e-1525
artery9.85e-1542
arterial blood vessel9.85e-1542
arterial system9.85e-1542
anatomical system2.42e-14625
anatomical group3.16e-14626
regional part of cerebral cortex3.51e-1422
embryo3.65e-14612
circulatory system4.63e-14113
cardiovascular system8.05e-14110
embryonic structure3.49e-13605
developing anatomical structure3.49e-13605
germ layer3.88e-13604
embryonic tissue3.88e-13604
presumptive structure3.88e-13604
epiblast (generic)3.88e-13604
neocortex6.02e-1320
somite7.98e-1383
paraxial mesoderm7.98e-1383
presomitic mesoderm7.98e-1383
presumptive segmental plate7.98e-1383
trunk paraxial mesoderm7.98e-1383
presumptive paraxial mesoderm7.98e-1383
multilaminar epithelium1.74e-1282
systemic artery4.07e-1233
systemic arterial system4.07e-1233
adult organism8.90e-12115
dermomyotome1.68e-1070
epithelial tube3.29e-10118
skeletal muscle tissue4.13e-1061
striated muscle tissue4.13e-1061
myotome4.13e-1061
posterior neural tube4.82e-1015
chordal neural plate4.82e-1015
muscle tissue5.59e-1063
musculature5.59e-1063
musculature of body5.59e-1063


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.